Decreased CD4+CD45RA+ lymphocytes in peripheral blood of systemic lupus erythematosus can recover after separation from patient's sera

Nobutoh, Toshiko; Kohda, Mamoru; Ueki, Hiroaki

doi:10.1016/0923-1811(94)90094-9

Cited by 1 publication

(1 citation statement)

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“…In addition to specific T cells, polyclonally or oligoclonally stimulated T cells may also play a role in autoimmune disease. The evidence supporting a role for nonspecific T-cell activation in idiopathic systemic autoimmune diseases includes the fact that an increase in activated/memory CD4 ϩ T cells has been found in individuals with systemic lupus erythematosus, scleroderma, rheumatoid arthritis, and Sjogren's syndrome [11][12][13][14][15][16][17]. Although it is possible that this phenomenon reflects an increase in autoreactive cells, it seems more likely that such a pronounced shift in the T-cell population is due to a nonspecific expansion of activated/memory T cells in response to some kind of pro-inflammatory stimulation.…”

Section: Trichloroethylene Activates Cd4 ϩ T Cells 903mentioning

confidence: 99%

TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

Gilbert

Griffin

Pumford

1999

Drug Metabolism Reviews

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Trichloroethylene is an industrial solvent and has become a major environmental contaminant. Autoimmune-prone MRL +/+ mice were treated for up to 22 weeks with trichloroethylene in the drinking water (0, 2.5, and 5.0 mg/mL) in order to study the immunoregulatory effects of this environmental toxicant. After only 4 weeks of treatment, trichloroethylene was shown to promote the expansion of CD4+ T cells that expressed a memory/activation phenotype (i.e., CD44hi CD45RBlo) and secreted high levels of IFN-gamma, but not IL-4. In addition, trichloroethylene treatment accelerated the development of an autoimmune response in the MRL +/+ mice as evidenced by an earlier appearance of antinuclear antibodies and increased levels of total IgG2a. MRL +/+ mice treated with trichloroethylene for 22 weeks also contained antibodies specific for trichloroethylene adducts, suggesting the activation of trichloroethylene-specific T cells. The results suggest that trichloroethylene can stimulate antigen nonspecific as well as specific T cells that are capable of promoting autoimmunity in genetically predisposed individuals.

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Section: Trichloroethylene Activates Cd4 ϩ T Cells 903mentioning

confidence: 99%

TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

Gilbert

Griffin

Pumford

1999

Drug Metabolism Reviews

View full text Add to dashboard Cite

show abstract

Decreased CD4+CD45RA+ lymphocytes in peripheral blood of systemic lupus erythematosus can recover after separation from patient's sera

Cited by 1 publication

References 14 publications

TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

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Decreased CD4+CD45RA+ lymphocytes in peripheral blood of systemic lupus erythematosus can recover after separation from patient's sera

Cited by 1 publication

References 14 publications

TRICHLOROETHYLENE ACTIVATES CD4+T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

TRICHLOROETHYLENE ACTIVATES CD4+T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

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TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*

TRICHLOROETHYLENE ACTIVATES CD4⁺T CELLS: POTENTIAL ROLE IN AN AUTOIMMUNE RESPONSE*