Decreased Corneal Sensitivity in Patients with Dry Eye

Bourcier, Tristan; Acosta, M. Carmen; Borderie, Vincent; Borrás, Fernando; Gallar, Juana; Bury, Thierry; Laroche, L.; Belmonte, Carlos

doi:10.1167/iovs.04-1426

Cited by 223 publications

(175 citation statements)

References 20 publications

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“…This can be explained by another factor that may complicate the assessment of OSD using OSDI and it is corneal hypoesthesia. Corneal sensitivity tends to decrease with age but it is also a consequence of long-term effect of preservativecontaining antiglaucoma eye drops on corneal surface [19,20]. The chronic patients have less innervation of the ocular surface and as a consequence experience less pain and discomfort which can result in slightly better OSDI score.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were grouped into 4 categories by OSDI score: normal (scores 0-12), mild OSD symptoms (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), moderate OSD symptoms (23-32), severe OSD symptoms (33-100) [13]. Patients' medical records were used to obtain medical history including detailed data on the use of medication and duration of therapy.…”

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

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Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Barišić¹

2014

J Clin Exp Ophthalmol

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Purpose: To establish the prevalence of ocular surface disease (OSD) in glaucoma patients using topical intraocular pressure-lowering (IOP) therapy and to compare the frequency and severity of symptoms with the control group of normal subjects. Methods:This prospective, multicenter, observational study included patients with glaucoma in four different Departments of Ophthalmology. A matched group of normal subjects served as controls. For each patient we have collected detailed family history, clinical records and calculated ocular surface disease index (OSDI) scores (0-100), based on the information obtained from OSDI questionnaires. Results:In total, we have evaluated 160 patients. Of those, 110 were glaucoma patients and 50 were normal subjects. Among 110 glaucoma treated patients 83 (75%) had OSDI scores indicating mild to severe OSD. Among 50 patients without glaucoma 15 (30%) had OSDI score indicating mostly mild to moderate OSD. The severity of symptoms correlates with the number of IOP medications used and the duration of treatment. Conclusion:This study confirms the high prevalence of OSD in patients treated for glaucoma with topical IOP medications. The adverse effect of these agents can influence the compliance and successful treatment of glaucoma patients.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical and Experimental Ophthalmologymentioning

confidence: 99%

Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Barišić¹

2014

J Clin Exp Ophthalmol

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“…[12][13][14][15][16] Other studies however did not find any sex difference in corneal sensitivity. 17,18 Future studies are needed to confirm and further explore these differences, but also to clarify the exact role of ocular surface sensitivity in the symptomatology of DED.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Sex differences in clinical characteristics of dry eye disease

et al. 2018

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Please cite this article as: Vehof J, Sillevis Smitt-Kamminga N, Nibourg SA, Hammond CJ, Sex differences in clinical characteristics of dry eye disease, Ocular Surface (2018), doi: 10.1016/ j.jtos.2018.01.001. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusions: This large clinical study has shown that sex has a large influence on the symptomatology of DED, with significantly higher symptom scores and lower correlation between symptoms and signs in women compared to men. These findings are of importance in clinical practice and in conducting research into DED.

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“…In those groups with such an instrument, most have found decreased sensitivity to all three stimuli in dry eye patients. 105,106 However, some groups have found higher sensitivity to air flow in dry eye patients, 107,108 representing a different disease subtype or patients at different points on the disease continuum. Commercially available confocal microscopy units have identified that some dry eye patients have neuronal alterations in the corneal subbasal plexus structures.…”

Section: Neuropathic Ocular Pain and Implications For Dry Eye Diagnosismentioning

confidence: 99%

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

Galor

Levitt

Felix

et al. 2014

Eye

187

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Dry eye has gained recognition as a public health problem given its prevalence, morbidity, and cost implications. Dry eye can have a variety of symptoms including blurred vision, irritation, and ocular pain. Within dry eyeassociated ocular pain, some patients report transient pain whereas others complain of chronic pain. In this review, we will summarize the evidence that chronicity is more likely to occur in patients with dysfunction in their ocular sensory apparatus (ie, neuropathic ocular pain). Clinical evidence of dysfunction includes the presence of spontaneous dysesthesias, allodynia, hyperalgesia, and corneal nerve morphologic and functional abnormalities. Both peripheral and central sensitizations likely play a role in generating the noted clinical characteristics. We will further discuss how evaluating for neuropathic ocular pain may affect the treatment of dry eye-associated chronic pain.

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Decreased Corneal Sensitivity in Patients with Dry Eye

Abstract: Patients with dry eye exhibit corneal hypoesthesia after mechanical, thermal, and chemical stimulation that appears to be related to damage to the corneal sensory innervation.

Cited by 223 publications

References 20 publications

Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Prevalence of Ocular Surface Disease in Patients with Glaucoma using Topical Antiglaucoma Medications

Sex differences in clinical characteristics of dry eye disease

Neuropathic ocular pain: an important yet underevaluated feature of dry eye

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