Decreased Expression of Cytosolic Phospholipase A2 in Normal Conjunctiva May be Contributing to the Formation of Pterygium

Yavaş, Betül Demirciler; Duman, Rahmi; Tosun, Murat

doi:10.9734/or/2018/39923

Cited by 1 publication

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“…3 and 6) could result from hyperactive PLA1s and/or hypoactive PLA2s in ocular MMP patients and in patients at a different disease stage. Even though PLA2s have been reported to be overexpressed or overactive in some inflammatory conditions [45], they seem to have opposite roles in terms of ocular disease where PLA2s were found to be protective against pterygium formation, while downregulated expression of PLA2s has been reported in pterygium tissues compared with normal conjunctiva [46]. Further investigations are therefore needed to elucidate the enzymatic changes in ocular MMP.…”

Section: Discussionmentioning

confidence: 99%

Signaling lipids as diagnostic biomarkers for ocular surface cicatrizing conjunctivitis

et al. 2020

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Metabolomics has been applied to diagnose diseases, predict disease progression, and design therapeutic strategies in various areas of medicine. However, it remains to be applied to the ocular surface diseases, where biological samples are often of limited quantities. We successfully performed proof-of-concept metabolomics assessment of volume-limited cytology samples from a clinical form of chronic inflammatory cicatrizing conjunctivitis, i.e., ocular MMP and discovered metabolic changes of signaling lipid mediators upon disease onset and progression. The metabolomics assessment revealed active oxylipins, lysophospholipids, fatty acids, and endocannabinoids alterations, from which potential biomarkers linked to inflammatory processes were identified. Possible underlying mechanisms such as dysregulated enzyme activities (e.g., lipoxygenases, cytochrome P450, and phospholipases) were suggested which may be considered as potential therapeutic targets in future studies. Key messages & Metabolic profile of the ocular surface can be measured using impression cytology samples. & Metabolomics analysis of ocular pemphigoid is presented for the first time. & The metabolomics assessment of OCP patients revealed active oxylipins, lysophospholipids, fatty acids, and endocannabinoids alterations. & Several oxylipins are identified as diagnostic biomarkers for OCP.

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Section: Discussionmentioning

confidence: 99%