Decreased expression of thymic stromal lymphopoietin in salivary glands of patients with primary Sjögren’s syndrome is associated with increased disease activity

Hillen, Maarten R; Kruize, Aike A.; Bikker, Angela; Wijk, Marion Wenting-van; Hack, C. E.; Lafeber, Floris P. J. G.; Roon, Joël A G van

doi:10.3109/14397595.2015.1054089

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…Glutathione S-transferases are enzyme family that involved in limiting oxidative damage to tissues [28], and reported more common in Sjögren's syndrome [29]. Keratin is one of the proteins that have been investigated as disease parameters of Sjögren's syndrome [30,31].…”

Section: Discussionmentioning

confidence: 99%

Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

et al. 2020

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Oral dryness as a side effect of certain drugs is increasing. The aim of this study was to examine the change of the protein ingredient in saliva of oral dryness patients caused by calcium blocker. Six patients taking calcium blocker and six healthy elderly were enrolled. Unstimulated salivary flow rate, protein concentration, and flow rate of protein were measured and compared between the patients taking calcium blocker and healthy elderly. iTRAQ (Isobaric Tag for Relative and Absolute Quantitation) proteomic analysis was performed to extract the salivary protein changed in patient taking calcium blocker, and the intensities of Western blotting products were quantified (unpaired t-test). Unstimulated salivary flow rate was significantly lower on patients taking calcium blocker (p < 0.01). Protein concentration tended to be higher and the flow rate of protein tended to be lower on patients. As the result of iTRAQ proteomic analysis, calmodulin-like protein 3, glutathione S-transferase P, and keratin type I cytoskeletal 13 increased characteristically in patient taking calcium blocker, and the expression in calmodulin-like protein 3 was significantly larger (p < 0.01). The results of this study indicated that calmodulin-like protein 3 increased in patients taking calcium blocker and could be a salivary biomarker for oral dryness caused by calcium blocker.

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Section: Discussionmentioning

confidence: 99%

Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

et al. 2020

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“…As such, TSLP seems to function as a mediator in tissue homeostasis. 40 As discussed previously, SGECs express BAFF, 22 which is a critical factor in B-cell activation and survival. 24,41 The ectopic production of lymphocyte survival factors supports the expansion and persistence within the glands of autoreactive clones, naturally deemed to die for the scarce expression of follicle-associated chemokine receptors (such as CXCR5) and BAFF receptor.…”

Section: Salivary Gland Epithelial Cells and Activation Of The Interfmentioning

confidence: 96%

Salivary Gland Pathology in Sjögren's Syndrome

Campos

Hillen

Barone

2016

Rheumatic Disease Clinics of North America

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“…In selectively extracted lesions of Labial SG (LSG), Th2 molecules are detected in zones inside the GC from pSS patients [ 28 ], suggesting that Th2 cells might modulate initial B cells responses. However, the harmful roles of Th2 cells might be owed to invasion into specific zones and disease progression, since Th2 cells localized outside lymphocytes infiltrates are associated with beneficial effects, and normal Th2 cytokine genotypes (IL-4 and IL-13) are associated with a milder form of pSS [ 66 , 67 ]. Furthermore, the increased expression of IL-13 cytokine has been implicated in the pathogenesis of autoimmune disease including SS, regulating several responses of other T cells [ 68 ].…”

Section: Th2/treg Cells: T Cells Subsets With Ambiguous Implicatiomentioning

confidence: 99%

“…Additionally, the beneficial role of Th2 polarization in SS has also been indirectly associated through its cytokines. Thymic Stromal Lymphopoietin (TSLP), a cytokine involved in promotion of Th2 response, has showed a reduced expression in SG with systemic inflammation in pSS, likely allowing a Th1/Th17 associated pSS pathogenesis [ 66 ]. Thus, Th2 cells might perform distinct roles in SS disease, providing special features that promote B cells responses towards disease progression or being a flank of altered regulatory pathways.…”

Section: Th2/treg Cells: T Cells Subsets With Ambiguous Implicatiomentioning

confidence: 99%

T Cells Subsets in the Immunopathology and Treatment of Sjogren’s Syndrome

2020

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Sjogren’s syndrome (SS) is an autoimmune disease whose pathogenesis is characterized by an exacerbated T cell infiltration in exocrine glands, markedly associated to the inflammatory and detrimental features as well as the disease progression. Several helper T cell subsets sequentially converge at different stages of the ailment, becoming involved in specific pathologic roles. Initially, their activated phenotype endows them with high migratory properties and increased pro-inflammatory cytokine secretion in target tissues. Later, the accumulation of immunomodulatory T cells-derived factors, such as IL-17, IFN-γ, or IL-21, preserve the inflammatory environment. These effects favor strong B cell activation, instigating an extrafollicular antibody response in ectopic lymphoid structures mediated by T follicular helper cells (Tfh) and leading to disease progression. Additionally, the memory effector phenotype of CD8+ T cells present in SS patients suggests that the presence of auto-antigen restricted CD8+ T cells might trigger time-dependent and specific immune responses. Regarding the protective roles of traditional regulatory T cells (Treg), uncertain evidence shows decrease or invariable numbers of circulating and infiltrating cells. Nevertheless, an emerging Treg subset named follicular regulatory T cells (Tfr) seems to play a critical protective role owing to their deficiency that enhances SS development. In this review, the authors summarize the current knowledge of T cells subsets contribution to the SS immunopathology, focusing on the cellular and biomolecular properties allowing them to infiltrate and to harm target tissues, and that simultaneously make them key therapeutic targets for SS treatment.

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Decreased expression of thymic stromal lymphopoietin in salivary glands of patients with primary Sjögren’s syndrome is associated with increased disease activity

Cited by 9 publications

References 19 publications

Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

Protein Ingredient in Saliva on Oral Dryness Patients Caused by Calcium Blocker

Salivary Gland Pathology in Sjögren's Syndrome

T Cells Subsets in the Immunopathology and Treatment of Sjogren’s Syndrome

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