1993
DOI: 10.1203/00006450-199302000-00002
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Decreased Glucose Oxidation in Preterm Infants Fed a Formula Containing Medium-Chain Triglycerides

Abstract: ABSTRACT. Several formulas for preterm infants contain Abbreviations medium-chain triglycerides (MCT) to enhance fat absorption. Although fat absorption with MCT was slightly MCT, medium-chain triglyceride higher in several studies in preterm infants, a beneficial LCT, long-chain triglyceride Ra, rate of appearance effect on growth has only been reported in one publication. We hypothesized that when part of the fat blend of preterm formula is substituted by MCT oil, this might lead to a different metabolic pat… Show more

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Cited by 17 publications
(6 citation statements)
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“…Glucose is the main source of energy for the fetus before birth. After birth the role of glucose as an energy substrate decreases and a shift from glucose to a carbohydrate-fat mixture as the energy source is observed [15]. Almost half of the energy expenditure in neonates after birth is provided by fat oxidation.…”
Section: Discussionmentioning
confidence: 99%
“…Glucose is the main source of energy for the fetus before birth. After birth the role of glucose as an energy substrate decreases and a shift from glucose to a carbohydrate-fat mixture as the energy source is observed [15]. Almost half of the energy expenditure in neonates after birth is provided by fat oxidation.…”
Section: Discussionmentioning
confidence: 99%
“…Supplements of medium-chain triglycerides in preterm formula are tolerated and even decrease the malabsorption of total fat [12][13][14] . The lipases in breast milk have also been implicated in increasing the absorption of enteral fat [15] .…”
Section: Discussionmentioning
confidence: 99%
“…46−48 Preterm infants fed MCT formula also showed increased liver fat synthesis. 49 The rapid breakdown of MCT during metabolism has been speculated as a possible explanation, and a large amount of medium-chain fatty acids are transported to the liver to be oxidized. The limited oxidative metabolism capacity of the liver and the excessive acetyl CoA generated may activate the hepatic lipogenic pathway, promoting the de novo synthesis of fatty acids and the formation of triacylglycerols, resulting in fat accumulation and an increase in the metabolic burden of the liver.…”
Section: Mlct Improves Energy Metabolism and Inhibitsmentioning
confidence: 99%