2006
DOI: 10.1016/j.amjoto.2005.07.008
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Decreased hearing after combined modality therapy for head and neck cancer

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Cited by 23 publications
(24 citation statements)
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“…In addition, concurrent radiation was found not to be associated with hearing change. However, these findings should be interpreted with caution because concomitant toxins such as noise (Boettcher et al 1987; Gratton et al 1990) and radiation therapy to the head and neck (Chen et al 2006; Pearson et al 2006) have previously been shown to produce a synergistic effect leading to increased rates of ototoxicity. Neither of these two variables was explored in any detail, for example, radiation location was not taken into account.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, concurrent radiation was found not to be associated with hearing change. However, these findings should be interpreted with caution because concomitant toxins such as noise (Boettcher et al 1987; Gratton et al 1990) and radiation therapy to the head and neck (Chen et al 2006; Pearson et al 2006) have previously been shown to produce a synergistic effect leading to increased rates of ototoxicity. Neither of these two variables was explored in any detail, for example, radiation location was not taken into account.…”
Section: Discussionmentioning
confidence: 99%
“…Their results showed that 85% of patients presented changes in frequencies from 4 to 8 kHz and more than 50% of them presented a change equal to or higher than 10 dB [1]. …”
Section: Discussionmentioning
confidence: 99%
“…Auditory damage is one of the main complications of oncological therapy in patients with head and neck tumors [1]. Recently, the addition of chemotherapy (CT) with cisplatin to radiotherapy (RT) has been improving the survival rate of patients with these neoplasias, becoming a standard treatment for tumors locally advanced.…”
Section: Introductionmentioning
confidence: 99%
“…Radiation-induced sensorineural hearing loss (SNHL) has been observed in 49% of patients, immediately after treatment, and has a frequency of 55% at 2 to 8 years after therapy, among patients treated with cranial irradiation that had exposure to the inner ear (Ho et al, 1999;Kwong et al, 1996). In studies on chemoradiation treatment, a 53% frequency SNHL and 14% of ototoxicity have been reported (Pearson et al, 2006;Langenberg et al, 2004). Among patients who received radiotherapy for nasopharyngeal carcinoma, at least one-third developed significant SNHL after treatment (Ho et al, 1999;Kwong et al, 1996).…”
mentioning
confidence: 99%