Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state

Sugawara, Tomoko; Kikuchi, Katsuko; Tagami, Hachiro; Aiba, S.; Sakai, Shingo

doi:10.1016/j.jdermsci.2012.02.011

Cited by 39 publications

(41 citation statements)

References 41 publications

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“…As such, the delivery of serine to the SC of the skin may moisturize the skin . On the other hand, lactate, constituting about 10% in NMF, is reported to maintain the skin surface hydration in healthy and AD individuals by increasing the water molecules interacting with the OH group of serine in SC keratin . Consistently, the application of lactate alleviates dry skin symptoms .…”

Section: Discussionmentioning

confidence: 98%

Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

et al. 2017

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Section: Discussionmentioning

confidence: 98%

Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

et al. 2017

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“…Importantly the levels of these metabolites are depleted in aged and xerotic skin, and correlate with the severity of xerotic skin conditions such as AD [5,24,53,54]. Low NMF levels associated with an FLG gene mutation are a major risk factor for the development of AD, and by extension also asteatotic eczema [1,55,56].…”

Section: Discussionmentioning

confidence: 99%

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Danby

Brown

Higgs-Bayliss

et al. 2016

Skin Pharmacol Physiol

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Xerosis affects up to 75% of older people and develops as a result of a skin barrier defect. Emollients are widely used to treat xerosis; however, there is limited understanding of the differences between them and their effects on the skin barrier in older people. This study aimed to compare the effect of a commercially available emollient containing 5% urea, ceramide NP and lactate (test emollient) to an alternative emollient without these additives (control emollient) on the properties of the skin barrier in older people. Two cohorts of 21 volunteers aged >60 years with dry skin were recruited. The first applied the test emollient to one forearm and no treatment to the other for 28 days. The second compared the test emollient to the control emollient observing the same parameters. Effects on the skin barrier were determined by measuring skin barrier function, hydration, skin surface pH and by analysing Fourier transform infrared spectra before and after treatment. A third cohort of 6 young adults was recruited to investigate the effect of a single treatment with the test emollient on the molecular structure of the skin barrier at greater depths by employing the tape-stripping technique. The test emollient hydrated the skin to a significantly greater extent and for a longer period of time compared to the control emollient, an effect associated with a significant elevation of carboxylate groups (a marker of natural moisturizing factor content) within the stratum corneum. Furthermore, the test emollient imparted additional benefits to the structure and function of the skin barrier not exhibited by the control emollient. In conclusion, the test emollient addressed the pathological features of xerotic aged skin, supporting its use as first-line therapy for xerotic skin conditions in this population.

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“…It remains to be determined whether the addition of fi laggrinderived NMFs to topical formulations shows an additional benefi cial moisturizing effect compared to urea-and lactate-containing formulations. In the second study, application of pyrrolidone acid on human skin did not show any effect on skin hydration even with a fi vefold increase in concentration [ 48 ]. Topically applied UCA has only been assessed in relation to photo-protection and immunosuppression [ 49 , 50 ].…”

Section: Replacement Of Nmfsmentioning

confidence: 99%

Therapeutics and Other Interventions

Carlsen

2014

Filaggrin

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Decreased lactate and potassium levels in natural moisturizing factor from the stratum corneum of mild atopic dermatitis patients are involved with the reduced hydration state

Cited by 39 publications

References 41 publications

Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

Decrease of superficial serine and lactate in the stratum corneum due to repetitive frictional trauma

The Effect of an Emollient Containing Urea, Ceramide NP, and Lactate on Skin Barrier Structure and Function in Older People with Dry Skin

Therapeutics and Other Interventions

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