Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis

Wu-Wang, C.Y.; Patel, Monali; Feng, Jian; Milles, Maano; Wang, S.L.

doi:10.1016/0003-9969(95)00095-x

Cited by 36 publications

(31 citation statements)

References 39 publications

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“…Za potrebe istraživanja zabilježeni su sljedeći podatci: dob, spol, pušenje i količina nestimulirane sline. Količina sline mjerila se prije svakog mjerenja, između 8 i 10 sati Wu Wangovom metodom (20). Jedan sat prije mjerenja ispitanici nisu jeli, pili, prali zube niti žvakali žvakaću gumu.…”

Section: Ispitaniciunclassified

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Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Richter

Alajbeg

Boras

et al. 2015

Acta Stomatol Croat

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Adresa za dopisivanje izv. prof. dr. sc. Vlaho Brailo Stomatološki fakultet Sveučilišta u Zagrebu Zavod za oralnu medicinu Gundulićeva 5, 10 000 Zagreb brailo@sfzg.hr Sažetak Svrha ispitivanja: Bioimpedancija je otpor prolasku električne struje kroz tkivo i ovisi o njegovoj strukturi i kemijskom sastavu. Svrha istraživanja bila je mapirati bioimpedancijske spektre za svaku regiju usne šupljine. Ispitanici i postupci: U mjerenju bioimpedancije sudjelovalo je tridesetero ispitanika s urednim nalazom oralne sluznice, a obavljalo se na 14 lokalizacija u usnoj šupljini s lijeve i desne strane te je ponovljeno nakon sedam i četrnaest dana. Rezultati: Najniže vrijednosti izmjerene su na dorzumu jezika, a najviše na tvrdom nepcu. Nije ustanovljena statistički značajna razlika između mjerenja na lijevoj i desnoj strani. Statistički značajno više vrijednosti izmjerene su ženama na sluznici gornje usne, dorzumu jezika i na ventralnom dijelu jezika. Utvrđena je statistički značajna razlika između nepušača i pušača na sluznici donje usne i sluznici dna usne šuplji-ne. Vrijednosti bioimpedancije bile su u negativnoj korelaciji s količinom sline na sluznici gornje usne, na tvrdom nepcu, dorzumu jezika i na podjezičnoj sluznici. Mjerenja pri niskim frekvencijama imala su veću varijabilnost. Zaključak: Vrijednosti bioimpedancije najčešće ovise o stupnju keratinizacije sluznice. Na njihove vrijednosti vjerojatno utječu demografski i klinički čimbenici, što je potrebno razjasniti u daljnjim studijama s većim brojem ispitanika. Ključne riječi električna impedancija, oralna sluznicaZavod za oralnu medicinu Stomatološkog fakulteta Sveučilišta

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Section: Ispitaniciunclassified

“…The following patient data were recorded: age, gender, smoking and unstimulated salivary flow rate. Salivary flow was measured prior to each impedance measurement, between 8-10 AM, using the method by Wu Wang (20). One hour before the measurement, the subjects did not eat, drink, brush their teeth, or chew a chewing gum.…”

Section: Subjectsmentioning

confidence: 99%

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Richter

Alajbeg

Boras

et al. 2015

Acta Stomatol Croat

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“…Dilaporkan bahwa penderita stomatitis mempunyai kadar PGE 2 yang menurun. 5 Prostaglandin dalam saliva mempunyai peran sebagai mekanisme pertahanan mukosa mulut seperti peran prostaglandin dalam pertahanan mukosa di lambung. Penghambatan COX-1 pada mukosa lambung memicu terjadinya penurunan mukus dan bikarbonat pada lambung, mengurangi aliran darah mukosa, kerusakan vaskular, akumulasi leukosit, penurunan kemampuan turnover, dan semua faktor yang berkontribusi pada perbaikan mukosa.…”

Section: Hasilunclassified

“…4 Prostaglandin (PGE 2 ) saliva berkurang selama tahap ulseratif dari stomatitis. 5 Peranan PGE 2 pada epitel mukosa lambung dan epitel mukosa rongga mulut diduga karena adanya persamaan struktur. Indikasi lama pemberian Aspirin disarankan tidak lebih dari 10 hari untuk mengatasi nyeri.…”

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Pengaruh lama pemberian aspirin pada ekspresi protein KI-67 dan ketebalan epitel mukosa rongga mulut tikus Wistar jantan (The effect of aspirin administration period on KI-67 expression protein and oral epithelial mucosal thickness in male Wistar mice)

Arinawati

Susilowati

Supriatno

2014

Dent. J. (Majalah Kedokteran Gigi)

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“…Immunopathogenetic studies indicate that these ulcerations might be caused by cytotoxic action of lymphocytes and monocytes on the oral epithelium with an unknown trigger. Immunologic and/or cytokine aberration leading to local tissue destruction have also been implicated [2,3,4,6,7,8,9,10,11,12]. …”

Section: Introductionmentioning

confidence: 99%

Salivary Epidermal Growth Factor Levels in Behçet’s Disease and Recurrent Aphthous Stomatitis

Adışen¹,

Aral

Aybay

et al. 2008

Dermatology

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Background: Epidermal growth factor (EGF) in saliva is cytoprotective against injuries and contributes to the maintenance of the integrity of the gastrointestinal mucosa. Low salivary EGF levels have been observed in patients with various forms of oral mucosal disease. Objective: Our aim wasto determine whether salivary EGF is low in patients with recurrent aphthous stomatitis (RAS) or those with Behçet’s disease (BD) when compared with healthy controls. Methods: The study population consisted of 33 BD and 16 RAS patients and 60 healthy controls. Measurement of EGF concentration in human saliva was performed with an enzyme-linked immunosorbent assay using an antibody-coated solid phase. Results: The mean salivary EGF levels (±SD) of active (with oral ulceration) and inactive stages (absence of oral ulceration) of BD (1,939.7 ± 1,561.5 and 2,305.7 ± 1,481.6 pg/ml, respectively) and RAS patients (1,650.5 ± 704.7 and 1,069.9 ± 539.2 pg/ml, respectively) were both lower than those of the healthy controls (2,758.7 ± 1,657.9 pg/ml) (p < 0.05 for each). Conclusions: BD and RAS patients have reduced salivary EGF levels even in the absence of oral ulcerations. EGF could be involved in the pathogenesis of BD and RAS by disturbing the mucosal integrity that may result in a susceptibility to the development of oral ulcers in these diseases.

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Decreased levels of salivary prostaglandin E2 and epidermal growth factor in recurrent aphthous stomatitis

Cited by 36 publications

References 39 publications

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Mapping Electrical Impedance Spectra of the Healthy Oral Mucosa: a Pilot Study

Pengaruh lama pemberian aspirin pada ekspresi protein KI-67 dan ketebalan epitel mukosa rongga mulut tikus Wistar jantan (The effect of aspirin administration period on KI-67 expression protein and oral epithelial mucosal thickness in male Wistar mice)

Salivary Epidermal Growth Factor Levels in Behçet’s Disease and Recurrent Aphthous Stomatitis

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