Decreased Lipid Peroxidation Following Periodontal Therapy in Type 2 Diabetic Patients

Abstract

Although this is a small and preliminary study, and the changes of LPO and anti-MDA-LDL antibody were within the normal range, the initial periodontal therapy significantly decreased LPO, an oxidative stress index, in type 2 diabetic patients with periodontal disease.

Effect of Non-Surgical Therapy on Salivary Nitric Oxide and Lipid Peroxidation Levels in Type Ii Diabetic and Non Diabetic Patients With Periodontal Disease

“…This result is in agreement with various other studies [51,52]. This result may be due to the fact that patients with well-controlled diabetes mellitus might respond to non-surgical therapy similarly well as healthy controls [48] and many of the patients in this study were controlled, diabetic patients.…”

“…periodontitis and control group whereas a study by Sonoki et al [48] demonstrated an elevated LPO level in patients with diabetes and periodontitis when compared with periodontitis. LPO was measured by an alternative method which indicates an earlier step in LPO.…”

“…The significant decrease of MDA after therapy suggests that the total antioxidant capacity in chronic periodontitis appears to be restored to control level by successful nonsurgical therapy. Sonoki et al [48] suggested that periodontal therapy presumably might have an antioxidant effect equal to those of antioxidant therapies, such as vitamin E administration in type 2 diabetic patients.…”

La Obesidad y su Relación con las Patologías Periodontales: una Revisión Narrativa

“…El mecanismo biológi-co radica en que el tejido adiposo produce adipoquinas, las cuales podrían modular la periodontitis. El problema deriva de un estado inflamatorio caracterizado por resistencia a la insulina y el estrés oxidativo, siendo este último un vínculo común con periodontitis en una relación bidireccional (Bullon et al, 2009), hay que considerar que la periodontitis puede por sí provocar estrés oxidativo (Sonoki et al, 2006) por medio de la alteración de los niveles de adipocitoquinas (Karthikeyan & Pradeep, 2007).…”

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

“…The effects of a hyper-inflammatory state seen in severe uncontrolled periodontitis and its impact on organs distant from the focus of inflammation are well documented in the context of oxidative stress-inducing mechanisms and the role of antioxidants (Soory 2009 (Tilg and Moschen 2008). In the context of substances derived from oxidative damage, plasma lipid peroxidation plays an important role in the diabetic periodontal patient (Sonoki et al 2006) with decreased lipid peroxidation following periodontal therapy. The pathogenesis and progression of periodontal disease is escalated by advanced glycaemic end products AGE (Takeda et al 2006), receptor for AGE (RAGE) which is highly expressed in periodontal tissues and AGE/RAGE interactions in uncontrolled diabetics.…”