Decreased Lung Tumorigenesis In Mice With Conditionally Inactivated Enpp2 Gene In CC10+ (Clara) Cells

Oikonomou, Nikos; Thanasopoulou, Artemis; Stathopoulos, Georgios T.; Syrigos, Kostas; Aidinis, Vassilis

doi:10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2056

A61. Molecular Pathogenesis of Lung Cancer 2010

DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a2056

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Decreased Lung Tumorigenesis In Mice With Conditionally Inactivated Enpp2 Gene In CC10+ (Clara) Cells

Nikos Oikonomou

Artemis Thanasopoulou²,

Georgios T. Stathopoulos

et al.

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Autotaxin and Endotoxin-Induced Acute Lung Injury

et al. 2015

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Acute Lung Injury (ALI) is a life-threatening, diffuse heterogeneous lung injury characterized by acute onset, pulmonary edema and respiratory failure. Lipopolysaccharide (LPS) is a common cause of both direct and indirect lung injury and when administered to a mouse induces a lung phenotype exhibiting some of the clinical characteristics of human ALI. Here, we report that LPS inhalation in mice results in increased bronchoalveolar lavage fluid (BALF) levels of Autotaxin (ATX, Enpp2), a lysophospholipase D largely responsible for the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) in biological fluids and chronically inflamed sites. In agreement, gradual increases were also detected in BALF LPA levels, following inflammation and pulmonary edema. However, genetic or pharmacologic targeting of ATX had minor effects in ALI severity, suggesting no major involvement of the ATX/LPA axis in acute inflammation. Moreover, systemic, chronic exposure to increased ATX/LPA levels was shown to predispose to and/or to promote acute inflammation and ALI unlike chronic inflammatory pathophysiological situations, further suggesting a differential involvement of the ATX/LPA axis in acute versus chronic pulmonary inflammation.

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Autotaxin and Endotoxin-Induced Acute Lung Injury

et al. 2015

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Autotaxin and lysophosphatidic acid signalling in lung pathophysiology

Magkrioti¹

2013

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Decreased Lung Tumorigenesis In Mice With Conditionally Inactivated Enpp2 Gene In CC10+ (Clara) Cells

Cited by 2 publications

References 0 publications

Autotaxin and Endotoxin-Induced Acute Lung Injury

Autotaxin and Endotoxin-Induced Acute Lung Injury

Autotaxin and lysophosphatidic acid signalling in lung pathophysiology

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