Decreased mi<scp>R</scp>‐146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1型糖尿病患者外周血单个核细胞miR‐146表达下调与胰岛持续免疫失衡相关

Yang, Mei; Ye, Lei; Wang, Bokai; Gao, Jie; Liu, Ruixin; Hong, Jie; Wang, Weiqing; Gu, Weiqiong; Ning, Guang

doi:10.1111/1753-0407.12163

Cited by 111 publications

(100 citation statements)

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“…Downregulation of miR-146b-5p in PBMC from T1D patients has been described before [168], but we did not detect a deviation of miR-146b-5p in serum from T1D patients, and to our knowledge it has not been reported by any other another study. For miR-151, it seems likely that this miRNA has a relation to metabolic processes, since it has been connected to mitochondrial activity [227], and decreased serum levels of both miR-151a-3p and -5p have been demonstrated after exercise [228].…”

Section: Mirnas Associated To Glucose Homeostasis Within the High-riscontrasting

confidence: 65%

“…Each miRNA can bind to multiple mRNAs, creating a complex regulatory network affecting many physiological and pathological processes [165][166][167]. In T1D, there are reports on differentially expressed miRNAs in PBMCs [168][169][170][171], and specific immune cell subsets like regulatory T cells [172]. There is also experimental data showing altered levels of miRNAs within the islets of NOD-mice during the pre-diabetic phase, and the expression of specific miRNAs was affected when exposing both murine-and human islets to pro-inflammatory cytokines [173].…”

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confidence: 99%

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Aspects of the Pre-Diabetic Perios in Type 1 Diabetes

Åkerman¹

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Type 1 diabetes (T1D) is an autoimmune disease characterized by insulin deficiency, due to immune-mediated destruction of beta cells. Current knowledge regarding the period preceding disease onset comes, to a large extent, from studying risk cohorts based on relatives of T1D-patients, as they have an increased disease risk. Among T1D patients in general, however, few have the disease in their immediate family. It is therefore important to study risk cohorts from the general population as well. An ongoing autoimmune reaction can often be seen in the blood long before disease onset, by detection of autoantibodies directed towards beta cell antigens. By autoantibody screening among participants in the ABIS (All Babies in the South-east of Sweden) cohort, we could identify a group of children from the general population with increased risk for T1D, positive for multiple autoantibodies. They were enrolled in a 2-year prospective follow-up aiming to characterize the prediabetic period and to identify factors indicative of progression/non-progression to T1D. We assessed glucose homeostasis and autoantibody titers over time, and searched for risk-biomarkers by analyzing the expression of immune-related genes (Th1-Th2-Th3) in peripheral blood mononuclear cells (PBMC) from these children, in comparison to healthy children and newly diagnosed T1D patients. In the same groups we also compared serum micro RNA (miRNA) profiles, knowing that miRNA molecules have desirable biomarker properties. We found that two specific autoantibodies, IA2A and ZnT8A, were detected at higher concentrations in riskindividuals who progressed to overt T1D during or after the follow-up period, compared to those who still have not. We also observed disturbed glucose homeostasis long before onset in the progressors, but it was seen among those who remain symptom free as well. Further, we found support for the possible role of insulin resistance as an accelerator of the disease process. For gene expression and serum miRNA, few differences were observed between risk-individuals and healthy children overall. However, for PBMC gene expression and serum miRNA both, there were associations to beta cell function and glucose homeostasis, and for miRNA also to islet autoantibodies. Although specific profiles for prediction of disease onset or identification of risk-individuals could not be found, these results are interesting and deserve to be evaluated further. As part of another sub-study within ABIS, the effects of physical activity on glucose homeostasis were assessed in healthy schoolchildren.The level of physical activity, measured by pedometers, was related to insulin resistance and beta cell-stress, and decreased physical activity was associated with increased insulin resistance and load on the insulin-producing beta cells, already at school-age.

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Section: Mirnas Associated To Glucose Homeostasis Within the High-riscontrasting

confidence: 65%

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confidence: 99%

Aspects of the Pre-Diabetic Perios in Type 1 Diabetes

Åkerman¹

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“…The study also showed that the miR-146 levels were associated with ongoing islet autoimmunity. 64 Moreover, miR-21a and miR-93 are decreased in PBMCs from T1D patients; 65 both miRNAs have been reported to participate in inflammatory and apoptosis signaling pathways 39 and are not affected by glucose stimuli. 65 Thus, the two miRNAs might be involved in the autoimmune responses of T1D.…”

Section: Mirnas: Regulators Of Immune Pathogenesis In T1dmentioning

confidence: 99%

“…63 Several possible target genes of miR-326, including vitamin D receptor and erythroblastosis virus E26 oncogene homolog 1, are vital modulators of the immune system, suggesting that the miRNA probably has important effects on autoimmunity in T1D by targeting these genes. 63 Another study performed by Yang et al 64 identified 26 differentially expressed miRNAs in PBMCs from newly diagnosed T1D patients, among which miR-146 was the most downregulated molecule. The study also showed that the miR-146 levels were associated with ongoing islet autoimmunity.…”

Section: Mirnas: Regulators Of Immune Pathogenesis In T1dmentioning

confidence: 99%

“…miR-146 was one of the most downregulated molecules and was linked to ongoing islet autoimmunity in T1D patients. 64 In addition, miR-21a and miR-93 are downregulated in the PBMCs of T1D patients compared with healthy individuals. 65 In addition to controlling gene expression in blood cells, many miRNAs are also detected in serum or plasma and other body fluids (that is, urine, saliva and breast milk) in association with microparticles, such as microvesicles or exosomes, or with proteins (for example, Argo-2).…”

Section: Mirnas: Participants In Autoimmunity-mediated β-Cell Damagementioning

confidence: 99%

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miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes

2017

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MicroRNAs (miRNAs) are a series of conserved, short, non-coding RNAs that modulate gene expression in a posttranscriptional manner. miRNAs are involved in almost every physiological and pathological process. Type 1 diabetes (T1D) is an autoimmune disease that is the result of selective destruction of pancreatic β-cells driven by the immune system. miRNAs are also important participants in T1D pathogenesis. Herein, we review the most recent data on the potential involvement of miRNAs in T1D. Specifically, we focus on two aspects: the roles of miRNAs in maintaining immune homeostasis and regulating β-cell survival and/or functions in T1D. We also discuss circulating miRNAs as potent biomarkers for the diagnosis and prediction of T1D and investigate potential therapeutic approaches for this disease.

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miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

Dey

Yousefiasl

Kumar

et al. 2022

Bioengineering & Transla Med

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MicroRNAs (miRNAs) as therapeutic agents have attracted increasing interest in the past decade owing to their significant effectiveness in treating a wide array of ailments. These polymerases II‐derived noncoding RNAs act through post‐transcriptional controlling of different proteins and their allied pathways. Like other areas of medicine, researchers have utilized miRNAs for managing acute and chronic wounds. The increase in the number of patients suffering from either under‐healing or over‐healing wound demonstrates the limited efficacy of the current wound healing strategies and dictates the demands for simpler approaches with greater efficacy. Various miRNA can be designed to induce pathway beneficial for wound healing. However, the proper design of miRNA and its delivery system for wound healing applications are still challenging due to their limited stability and intracellular delivery. Therefore, new miRNAs are required to be identified and their delivery strategy needs to be optimized. In this review, we discuss the diverse roles of miRNAs in various stages of wound healing and provide an insight on the most recent findings in the nanotechnology and biomaterials field, which might offer opportunities for the development of new strategies for this chronic condition. We also highlight the advances in biomaterials and delivery systems, emphasizing their challenges and resolutions for miRNA‐based wound healing. We further review various biovectors (e.g., adenovirus and lentivirus) and abiotic materials such as organic and inorganic nanomaterials, along with dendrimers and scaffolds, as the delivery systems for miRNA‐based wound healing. Finally, challenges and opportunities for translation of miRNA‐based strategies into clinical applications are discussed.

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Decreased miR‐146 expression in peripheral blood mononuclear cells is correlated with ongoing islet autoimmunity in type 1 diabetes patients 1型糖尿病患者外周血单个核细胞miR‐146表达下调与胰岛持续免疫失衡相关

Abstract: The results suggest that dysregulation of miR-146 expression in PBMC may be associated with the ongoing autoimmune imbalance in T1D patients.

Cited by 111 publications

References 34 publications

Aspects of the Pre-Diabetic Perios in Type 1 Diabetes

Aspects of the Pre-Diabetic Perios in Type 1 Diabetes

miRNAs: novel regulators of autoimmunity-mediated pancreatic β-cell destruction in type 1 diabetes

miRNA‐encapsulated abiotic materials and biovectors for cutaneous and oral wound healing: Biogenesis, mechanisms, and delivery nanocarriers

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