Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients – A ³¹P‐MRS study

Abstract

Alterations in intramuscular ATP, PCr and fat content in FMS probably reflect a combination of inactivity related to pain and dysfunction of muscle mitochondria.

Fibromyalgia: A Critical and Comprehensive Review

“…This is further supported by reduced levels of muscular ATP and phosphocreatine, even if they are not consistently observed and even if it is not clear to what extent the physical inactivity and deconditioning of FMS patients contribute to these findings [488,[494][495][496]. Further evidence of mitochondrial dysfunction comes from PBMC and skin of FMS patients [435,497,498].…”

Signs of ongoing inflammation in female patients with chronic widespread pain

“…[10–13] In FMS, the top-down pain modulating systems appear to be impaired, [14] a condition that may contribute to central hyperexcitability. This is not to say that peripheral nociceptive input is unimportant; indeed, alterations in muscle biochemistry and peripheral nociceptors have been reported [15–22] and on-going peripheral input seems necessary if central hyperexcitability and other central alterations are to be maintained. [23] Indeed, both peripheral and central mechanisms may be important in the pathophysiology of CWP/FMS.…”

Characterization of brown adipose tissue by water–fat separated magnetic resonance imaging

“…Water–fat separated images were obtained using the inverse gradient method and the water–fat shift artifact was removed . A correction, as described in, was performed using a value of 13.3 ms for rodent BAT . The RFC was calculated by removing the intensity bias that was estimated from WAT voxels, defined as voxels with a fat fraction above 0.90, thus calibrating the images such that a value of one corresponds to WAT .…”