Decreased Neuromuscular Function in Crohn’s Disease Patients Is Not Associated with Low Serum Vitamin D Levels

Abstract

Crohn's disease patients with sufficient vitamin D levels experienced a 43 % greater extension peak torque. Although vitamin D deficiency has been associated with neuromuscular dysfunction, there were no differences in serum vitamin D levels between the CD and healthy controls to explain the decreased muscle strength.

Maintaining Muscle Strength in Crohn’s Disease: Can a Vitamin D Daily Keep Muscle Loss Away?

“…In this issue, Salacinski et al [5] have objectively demonstrated reduced lower limb muscle strength in subjects with Crohn's disease (CD) compared to healthy controls, confirming the work of previous studies [6,7]. However, the study was unable to show that this reduced strength was directly attributable to lower vitamin D (25-(OH) or vitamin D3) levels in CD subjects as originally hypothesized.…”

Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: a meta-analysis of 55 observational studies

“…Table 1 shows that the quality scores of the included studies ranged from 2 to 7, with a median of 5. Thirty-two studies [16, 18, 29–31, 33–35, 37–40, 44, 45, 47–49, 51, 52, 54, 55, 61, 62, 64–66, 70, 73–77] were considered high quality and the others [25–28, 31, 36, 41–43, 46, 50, 53, 56–60, 63, 67–69, 71, 72] were low quality.…”

“…A total of 31 studies [16, 25, 29, 31–36, 43, 44, 46, 49, 53–55, 57, 60–66, 68–72, 76, 77] were conducted on serum 25(OH)D levels in CD and healthy controls, and we conducted a meta-analysis of 29 effect values. We found mean serum 25(OH)D levels in patients with CD were significantly lower than in healthy controls (MD: − 3.17 ng/mL; 95% CI − 4.42 to − 1.93) (Fig.…”

Low muscle mass and sarcopenia: common and predictive of osteopenia in inflammatory bowel disease

“…Reversal of sarcopenia amongst 19 patients with active CD was recently demonstrated following infliximab administration, which correlated with a reduction in serum IL‐6 . Optimisation of nutritional status, in particular vitamin D, has an important role in muscle function . Small studies have shown that exercise may improve quality of life and clinical disease activity indices in outpatients with IBD .…”