Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma

Mumcu, Uğur; Kocer, Ibrahim; Ateş, Orhan; Harputluoğlu, Hakan

doi:10.18240/ijo.2016.10.24

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…To date, there has been increasing evidence to suggest that an imbalance in the oxidative stress system may be involved in the pathogenesis of glaucoma. Several studies have investigated the level of oxidative stress-related markers in the aqueous humor [ 7 , 22 ] and peripheral blood [ 9 , 23 , 24 ] of patients with glaucoma, as well as the expression of oxidative stress-related markers in humans [ 25 , 26 ] and an experimental glaucoma model's ocular tissues [ 27 ]. Engin et al [ 28 ] reported that the serum levels of TAS, SOD, and GPX decreased and serum levels of MDA increased in patients with glaucoma, which provides compelling evidence for imbalance in the oxidative stress system in the peripheral blood of glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Shao

et al. 2020

Oxidative Medicine and Cellular Longevity

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Purpose. To investigate the serum changes of oxidative stress markers and the relationship between these factors and visual field (VF) progression in patients with primary angle closure glaucoma (PACG). Methods. A case-control and a prospective cohort study. A total of 94 patients with PACG and 89 normal controls were enrolled. Furthermore, 94 PACG subjects were followed up for at least two years (once every six months). All participants were evaluated for serum levels of superoxide dismutase (SOD), total antioxidant status (TAS), hydrogen peroxide (H2O2), malondialdehyde (MDA), glutathione peroxidase, glutathione reductase, and detailed eye and systematic examination. Binary logistic regression analysis and Cox regression analysis were performed. Results. The serum levels of SOD and TAS in the PACG group were significantly lower than those in the control group (p<0.001). Meanwhile, PACG subjects had significantly higher levels of MDA and H2O2 than the normal control subjects (p<0.001). Serum levels of TAS (OR=0.773, 95%CI=0.349−0.714, p<0.001), SOD (OR=0.975, 95%CI=0.955−0.995, p<0.001), MDA (OR=1.155, 95%CI=1.080−1.235, p<0.001), and H2O2 (OR=1.216, 95%CI=1.142−1.295, p<0.001) were independent risk/protective factors for PACG. TAS levels (HR=0.041, 95%CI=0.008–0.218, p<0.001), SOD levels (HR=0.983, 95%CI=0.971–0.994, p=0.003), and MDA levels (HR=1.010, 95%CI=1.001–1.018, p=0.015) at baseline were associated with visual field progression. Kaplan–Meier curves reveal that patients with TAS<0.95/SOD<143/MDA>12 had a significantly higher percentage of PACG progression (p<0.05). Conclusions. Decreased levels of TAS and SOD as well as increased levels of MDA at baseline were associated with VF progression in patients with PACG. These findings suggest that oxidative stress was involved in the onset and development of PACG.

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Section: Discussionmentioning

confidence: 99%

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Shao

et al. 2020

Oxidative Medicine and Cellular Longevity

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“…Using the initial search strategy, we identified 482 articles, and 460 articles were excluded. A total of 22 studies [19, 23–43] were included in this meta-analysis. Detailed characteristics of each included study are presented in Tables 1 –4.…”

Section: Resultsmentioning

confidence: 99%

“…An increased intraocular pressure is a high risk factor of POAG, but normal intraocular pressure can also lead to optic nerve damage and loss of vision in POAG [45]. Although the causes of OAG are unknown, oxidative stress appears to play a role in progressive glaucomatous optic nerve damage [23, 30, 36]. The blood TAS in the meta-analysis of OAG patients decreased, which suggested a breakdown of the balance between the ROS generation and clearance systems.…”

Section: Discussionmentioning

confidence: 99%

The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis

Tang

Cao

et al. 2019

Journal of Ophthalmology

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Purpose To systematically evaluate the associations between oxidative stress status and different types of glaucoma. Design Systematic review and meta-analysis. Methods We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. A random effects model was used to estimate oxidative stress status along with weighted mean differences and 95% confidence intervals (CIs). A funnel plot analysis and Egger's test were performed to assess potential publication bias. Main outcome measures Oxidative stress status was abnormal and different in patients with OAG (open-angle glaucoma) and EXG (exfoliation glaucoma). Results Blood TAS (total antioxidant status) was lower in the OAG group than in the control group, with a mean difference of 0.580 mmol/L (p < 0.0001, 95% CI = −0.668 to −0.492). The aqueous humor SOD (superoxide dismutase), GPX (glutathione peroxidase), and CAT (catalase) levels were higher in the OAG group than in the control group, with mean differences of 17.989 U/mL (p < 0.0001, 95% CI = 14.579–21.298), 12.441 U/mL (p < 0.0001, 95% CI = 10.423–14.459), and 1.229 fmol/mL (p=0.042, 95% CI = 0.043–2.414), respectively. Blood TAS was lower in the EXG group than in the control group, with a mean difference of 0.262 mmol/L (p < 0.0001, 95% CI = −0.393 to −0.132). However, there were no differences in blood TOS and aqueous humor TOS between the EXG group and the control group. Conclusions This meta-analysis indicates that OAG patients had a lower TAS in the blood and higher levels of SOD, GPX, and CAT in the aqueous humor, while EXG patients only had a decreased TAS in the blood.

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“…In addition, content of MDA and NO in retinal tissue of ultrasound group was lower than that of NGF group and Rg1 group, and the content of SOD was higher than that of NGF group and Rg1 group, and the differences were statistically significant, indicating that the use of ultrasound microbubbles can achieve targeted drug administration to increase the drug concentration in eyes. So, ginsenoside Rg1 and NGF mediated by ultrasound targeted microbubble destruction is effective in the treatment of glaucomatous optic nerve damage, which may be related to the changed contents of NO, MDA and SOD ( 16 – 18 ). This study provided references for the studies on mechanism of the role of oxidative stress injury in the occurrence and development of glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction

2017

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The treatment of glaucomatous optic nervedamage using ginsenoside Rg1 mediated by ultrasound targeted microbubbles destruction was evaluated. Thirty healthy New Zealand white rabbits were subjected to injection of 0.3% carbomer solution to establish glaucomatous optic nerve damage model. Rabbits were divided into 5 groups: control group, model group, model group + intravitreal injection of nerve growth factor (NGF) group, model group + intravitreal injection of ginsenoside Rg1 group (Rg1 group), model group + intravitreal injection of ginsenoside Rg1 + ultrasound microbubble group (ultrasound group), model group + ultrasound targeted microbubble destruction (ultrasound group). Intraocular pressures were compared at 1, 2 and 4 weeks after model establishment. Rabbits were sacrificed 4 weeks after model establishment to collect retinal tissue for H&E staining. Histological changes were observed and the retinal thickness was measured. Contents of malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) were measured by ELISA. Intraocular pressure was significantly higher in model group than in control group at 1 week (P<0.05). Intraocular pressure was significantly lower in the ultrasound group than in NGF group and Rg1 group at all time-points (P<0.05). The number of ganglion cells in model group was decreased significantly. Number of nuclear layer cells was significantly reduced. Thickest retina was found in control group and model group was the thinnest (P<0.05). Contents of MDA and NO in model group were significantly higher than those in NCF group and Rg1 group. SOD content in control group was higher than that in ultrasound group and model group (P<0.05). In conclusion, treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction can reduce the level of oxidative stress, relieve intraocular pressure and reduce ganglion cell damage.

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Decreased paraoxonase1 activity and increased malondialdehyde and oxidative DNA damage levels in primary open angle glaucoma

Cited by 12 publications

References 15 publications

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

Relationship between Oxidative Stress Biomarkers and Visual Field Progression in Patients with Primary Angle Closure Glaucoma

The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis

Treatment of glaucomatous optic nerve damage using ginsenoside Rg1 mediated by ultrasound targeted microbubble destruction

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