Decreased Plasma and Urinary Dopamine during Dietary Sodium Depletion in Man*

Carey, Robert M.; Loon, Glen R. Van; Baínes, Andrew D.; Ortt, E M

doi:10.1210/jcem-52-5-903

Cited by 78 publications

(22 citation statements)

References 17 publications

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“…Conversely, sodium loading increases urinary dopamine levels (31). The mechanism for this increased dopamine excretion has been attributed to increased DOPA concentrations in plasma and tubular lumen (46) and increased proximal tubule DOPA uptake via a sodium-dependent cotransport process (44). Therefore, volume expansion may serve to decrease proximal tubule AT 1 receptor expression by decreasing local and/or systemic angiotensin II production and increasing proximal tubule dopamine production.…”

Section: Discussionmentioning

confidence: 99%

Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule.

Cheng¹,

Becker²,

Harris³

1996

J. Clin. Invest.

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Systemic and/or locally produced angiotensin II stimulates salt and water reabsorption in the renal proximal tubule. In vivo, dopamine (DA) may serve as a counterregulatory hormone to angiotensin II's acute actions on the proximal tubule. We examined whether dopamine modulates AT 1 receptor expression in cultured proximal tubule cells (RPTC) expressing DA 1 receptors. Dopamine decreased basal RPTC AT 1 receptor mRNA levels by 67 Ϯ 7% ( n ϭ 10; P Ͻ 0.005) and decreased 125 I-angiotensin II binding by 41 Ϯ 7% ( n ϭ 4; P Ͻ 0.05). The DA 1 -specific agonist, SKF38393 decreased basal AT 1 receptor mRNA levels (65 Ϯ 5% inhibition; n ϭ 5; P Ͻ 0.025), and the DA 1 -specific antagonist, SCH23390 reversed dopamine's inhibition of AT 1 receptor mRNA expression (24 Ϯ 10% inhibition; n ϭ 8; NS) and angiotensin II binding (5 Ϯ 15%; n ϭ 4; NS). DA 2 -specific antagonists were ineffective. In rats given L-DOPA in the drinking water for 5 d, there were decreases in both proximal tubule AT 1 receptor mRNA expression (80 Ϯ 5%; n ϭ 6; P Ͻ 0.005) and specific

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Section: Discussionmentioning

confidence: 99%

Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule.

Cheng¹,

Becker²,

Harris³

1996

J. Clin. Invest.

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“…In normal humans, urinary dopamine excretion is increased during sodium loading and, conversely, is decreased during sodium depletion. 4 ' 5 Exogenous administration of dopamine in sodium-replete humans produces renal vasodilation and increases urinary sodium excretion. 6 In experimental animals, blockade of the renal DA, receptor impairs the natriuretic response to acute sodium load and produces antinatriuresis by a renal tubular mechanism.…”

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confidence: 99%

Selective peripheral dopamine-1 receptor stimulation. Differential responses to sodium loading and depletion in humans.

et al. 1990

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“…33 However, in our study we could not demonstrate any beneficial effect on BP that Comparative studies between different variables could be reliably related to breast feeding, a result that although not consensual, is in agreement with The comparative study between haptoglobin phenotypes, showed that allele 1 carriers had significantly other authors. 34,35 In addition, the intake of the main nutrients, such as sodium, potassium and calcium lower plasma renin and urine aldosterone and cAMP concentrations than allele 2, but dopamine per se, did not appear to influence in any significant tor with renal origin) 37,38 was observed (Table 3). These findings suggest that a sodium sensitive tendency is already present at the age of 12 months.…”

Section: Discussionmentioning

confidence: 96%

Genetic and environmental factors regulating blood pressure in childhood: prospective study from 0 to 3 years

Guerra

Monteiro

Breitenfeld³

et al. 1997

J Hum Hypertens

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Objectives: Blood pressure (BP) regulation depends on(above the 75 percentile) maintained this tendency up to, at least, the age of 36 months. The comparison the interaction between multiple environmental and genetic factors. Of these, BP sensitivity to dietary sodium between SBP and diastolic BP (DBP) according haptoglobin phenotypes demonstrated that SBP was systemintake has been one that has been investigated in adults but not in children. The aim of the present study was to atically higher in allele 1, with apparently an increasing tendency with age, although the differences did not investigate, prospectively, the BP profile in relation to different genetic and hormonal factors, in the first 3 have statistical significance. The comparative study between haptoglobin phenotypes, with correction for years of life. Population and methods: Thirty-nine children born at the covariates fractional excretion of sodium and potassium, showed that allele 1 carriers had significantly term following normal pregnancies, with uncomplicated neonatal periods, were randomly selected to take part lower plasma renin and urine aldosterone and cAMP concentrations than allele 2, but dopamine excretion in the study. BP, weight and length were evaluated every 3 months from birth to 3 years. At the age of 12 months, was found to be higher in allele 1 than in allele 2. There were no differences among variables relating to family haptoglobin phenotypes and plasma active renin concentration were determined as well as random urine history of cardiovascular disease. Conclusions: There was an early tracking process of BP evaluation of aldosterone, cAMP, dopamine and digoxin-like immunoreactive substances (DLIS). Family values from the first 6 months of life which persists through, at least, to the age of 36 months. Differences history of cardio-vascular diseases was also recorded. Results: Systolic BP (SBP) demonstrated a gradual in sodium handling between haptoglobin 1 and 2 phenotypes were already present in early childhood, although increase until the age of 6 months with little variation up to 36 months. Tracking of SBP values was also no significant repercussion in BP values could be demonstrated in the 3-year duration of this study. observed from the first year as infants with high values Keywords: infant blood pressure; haptoglobin phenotype; BP sodium sensitivity diets since early life adopting as a reference the low

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Decreased Plasma and Urinary Dopamine during Dietary Sodium Depletion in Man*

Cited by 78 publications

References 17 publications

Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule.

Dopamine decreases expression of type-1 angiotensin II receptors in renal proximal tubule.

Selective peripheral dopamine-1 receptor stimulation. Differential responses to sodium loading and depletion in humans.

Genetic and environmental factors regulating blood pressure in childhood: prospective study from 0 to 3 years

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