Decreased plasma antioxidants in patients with Alzheimer's disease

Abstract

This study showed that oxidative injuries could be involved in the pathogenesis of AD, as well as indicating that some antioxidant might be associated with the cognitive functions in AD.

Serum Albumin Concentration and Cognitive Impairment

“…The current findings are consistent with a number of case control studies linking low levels of serum albumin with cognitive impairment [6,7] and dementia [5,8] However, results from previous population-based studies have been equivocal. Our results are similar to the linear association between serum albumin levels and MMSE performance in community-living older Chinese adults recently observed by Ng and colleagues.…”

“…For example, low levels of serum albumin were found to be associated with an increased risk of cognitive impairment in 1,511 hospitalized patients with heart failure, [6] and 331 elderly rehabilitation patients with hip fractures. [7] Lower levels of serum albumin have also been observed in Alzheimer's disease (AD) patients in comparison with healthy volunteer controls in some, [5,8] but not all small clinical studies [9]. However, results from large representative population-based studies are limited and equivocal, and the external validity of previous clinical results is largely unknown.…”

Altered Uric Acid Levels and Disease States

“…Serum uric acid levels that are below normal concentrations have also been linked to a variety of disease states, including multiple sclerosis, optic neuritis, Parkinson's disease, and Alzheimer's disease (Church and Ward, 1994;Toncev et al, 2002;Knapp et al, 2004;de Lau et al, 2005;Kim et al, 2006). In these inflammatory diseases, a decreased UA concentration may not be able to prevent the toxicity by reactive oxygen and nitrogen species that form as a result of the inflammation.…”

Oxidative Stress in Neurodegenerative Diseases

“…Differences in results might be caused by measurement of antioxidants at different disease stages (fully developed disease vs. subclinical stage of the disease) [219][220][221].…”