Decreased Resistance to Tumor Cells after Stress, Followed by Increased Resistance.

Minster, John J.

doi:10.3181/00379727-113-28370

Cited by 6 publications

(2 citation statements)

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“…Lymphoid cells obtained from rats subjected to bums or surgical injury are unable to manifest graft-vs.-host reactions in recipient rats differing at a minor histocompatibility locus (22). The incidence of tumor take (23,24) and spontaneous metastases (25) is increased when tumorinjected animals are subjected to surgical operations. The number of T lymphocytes is significantly decreased after burns as measured by rosette formation with sheep erythrocytes (26).…”

Section: Resultsmentioning

confidence: 99%

Generation of suppressor cells in mice after surgical trauma.

Wang¹,

Heacock²,

Wu³

et al. 1980

J. Clin. Invest.

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A B S T R A C T Immunoincompetency is often seen in patients after various types of trauma and is associated with increased morbidity and mortality from infectious complications. To understand better the immunologic impairment associated with trauma, we have studied this phenomenon in an animal model. Splenocytes from mice traumatized by amputation of their right hind limbs were consistently shown to have a diminished capacity to proliferate in response to alloantigens and to form alloreactive cytolytic cells in mixed lymphocyte cultures. Anesthesia itself had no effect in this system. The immunoincompetency was detected from 2 h to 6 d after surgical trauma and was completely reversed by removing adherent and phagocytic cells from the splenocytes. Furthermore, addition of splenocytes from traumatized mice to mixed lymphocyte cuiltures from normal mice prevented normal lymphocytes from responding to alloantigens, suggesting the existence of suppressor cells. The suppressor cells were found to adhere to glass and to nylon wool columns, and were contained within an esterase-positive cell population. They were insensitive to treatment with anti-Thy 1.2 and anti-Ig sera in the presence of complement. Therefore, the present results suggest that a Thy 1.2-negative, Ig-negative, esterase-positive cell population capable of adhering to glass and nylon wool, presumably macrophages, was responsible for the inhibition of the responsiveness of lymphocytes to alloantigens in traumatized animals.

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Section: Resultsmentioning

confidence: 99%

Generation of suppressor cells in mice after surgical trauma.

Wang¹,

Heacock²,

Wu³

et al. 1980

J. Clin. Invest.

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“…Minster (28) found that the take of cancer cells injected subcutaneously in rats was greatly increased at the time of stress (celiotomy and nembutal anesthesia), gradually decreased to control value of non-operated rats about the 8th day, and reached a maximal resistance at about 18th day. Then the resistance to take gradually returned to control level within the next 10 days.…”

Section: Studies Of Surgical Stress In Experimental Animalsmentioning

confidence: 99%

Effect of anesthesia and surgery on immunity

Lee

1977

Journal of Surgical Oncology

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The observed phenomenon that multiple distant metastases may appear and grow rapidly after operation on the primary cancer is very distressing. Many experimental results suggest that surgical procedures may precipitate dissemination and growth of tumor in some instances, but the overwhelming evidences document that surgical reduction of tumor bulk can achieve cure for the host and restore the immunity lost in the face of growing tumors. Various anesthetics were shown to interfere with many phases of the immune response. But recent studies suggest that the inhibitory effect of anesthesia alone is minimal. Depression of lymphocyte transformation, detectable as early as 2 hours after induction, was related primarily to the extent of tissue trauma, the amount of blood loss, duration of operation, and whether thoracic or abdominal cavity was entered. Posoperative changes of lymphocyte counts and transformation responses usually returned to normal values within a week, whereas depression of specific cellular immunity to tumor-associated antigen in vitro, and delayed cutaneous hypersensitivity reactions in vivo, persisted for about a week and gradually returned to normal by 3 weeks. Presently the clinical significance of such transitory depression of host immunity is not known. It is hoped that this review may stimulate interest in further experimental and clinical research.

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Restoration of immunologic memory in the tumor‐bearing mouse

Humphrey

Boehm

Fetter

1974

Journal of Surgical Oncology

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Using C3H/HeHa mice and a transplanted methylcholanthrene sarcoma induced in this strain, the effect of simple and radical amputation of the tumor-bearing leg on tumor immunity was evaluated. Radical amputation of the tumor-bearing leg removed the protective effect upon subsequent tumor challenge while immunity was present in mice submitted to only simple amputation of the tumor-bearing leg. However, radical amputation of the contralateral normal leg resulted in failure to demonstrate protection to subsequent challenge. These data suggest that severe stress is the cause of lack of demonstrable immunity in these mice.tation. When injected immediately after the operative stress, no immunity to tumor was seen. On the other hand, if the vaccine was injected 12 days after operation, protection once again was demonstrated.

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Decreased Resistance to Tumor Cells after Stress, Followed by Increased Resistance.

Cited by 6 publications

References 0 publications

Generation of suppressor cells in mice after surgical trauma.

Generation of suppressor cells in mice after surgical trauma.

Effect of anesthesia and surgery on immunity

Restoration of immunologic memory in the tumor‐bearing mouse

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