Decreased Resting-State Activity in the Precuneus Is Associated With Depressive Episodes in Recurrent Depression

Liu, Chunhong; Ma, Xin; Yuan, Zhen; Song, Lina; Jing, Bing; Lu, Hongsheng; Tang, Liming; Fan, Jin; Walter, Martin; Liu, Cun‐Zhi; Wang, Lihong; Wang, Chuanyue

doi:10.4088/jcp.15m10022

Cited by 54 publications

(33 citation statements)

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“…In a meta-analysis conducted by Liu et al, patients with recurrent MDD exhibited decreased fALFF in the right posterior insula and right precuneus, increased fALFF in the left ventral anterior cingulate cortex, and decreased fALFF in the right precuneus, and increased fALFF in the right middle insula was correlated with the number of depressive episodes in the recurrent MDD groups and remitted MDD groups. 28 Our results are fairly similar to the results of this meta-analysis, as we found lower fALFF value in the right precuneus, as well as a correlation between the value of decreased fALFF and the number of depressive episodes. As our study only included first-episode patients with MDD, the correlation of fALFF and episodes was not examined, but the decreased fALFF was correlated with more severe depressive symptoms.…”

Section: Discussionsupporting

confidence: 91%

Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Li¹,

Rossbach²,

Zhang³

et al. 2018

NDT

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BackgroundMajor depressive disorder (MDD) is a leading psychiatric disorder that has a lack of biomarkers for a diagnosis.PurposeThe objective of this study was to examine the structural and functional change in the precuneus within first-episode drug naive patients with MDD.MethodsThirty-two first episode drug-naive patients with MDD and thirty healthy controls (HCs) were recruited in this study; the structural MRI and fMRI data were collected using the 3.0 T Trio Siemens System. All the patients were interviewed using the HAMD-17.ResultsThe difference between gray matter volume within the two groups was not observed. Results indicated that the low-frequency fluctuations (ALFF), fractional ALFF (fALFF) and regional homogeneity values of the precuneus within first-episode drug-naive patients with MDD were lower than the HCs. In addition, the fALFF value of the MDD was negatively and statistically significantly correlated with the HAMD-17 total score (P<0.05).ConclusionThe current study found abnormal activity of the precuneus at resting state in first-episode drug-naive patients with MDD, indicating that activity within the precuneus may be a potential biomarker for the diagnosis of MDD.

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Section: Discussionsupporting

confidence: 91%

Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Li¹,

Rossbach²,

Zhang³

et al. 2018

NDT

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“…Furthermore, we found significantly increased FC between L-MOG and L-mPFG and hippocampus. The mPFG and its adjacent areas play a crucial role in depression symptomatology [ 46 , 47 , 55 ]. It has been confirmed that mPFG was involved in self-referential thought [ 30 ] and depressive rumination [ 30 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder

Teng

Zhou²,

et al. 2018

BMC Psychiatry

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BackgroundWomen are more susceptible to major depressive disorder (MDD). A possible explanation is that women have a trait tendency to engage in a ruminative response style. Depending on cognitive model of depression, attention bias, memory bias and self-referential bias were closely related among depressed patients. Previous studies have explored the neural mechanism of the cognitive biases by using amplitude of low frequency fluctuations (ALFF) or functional connectivity (FC), and few combined these two metrics, especially focusing on female patients.MethodsWe assessed 25 female patients diagnosed with MDD and 13 well matched healthy controls (HCs) using Rs-fMRI. Two metrics ALFF and FC based on abnormal ALFF were explored and made comparisons.ResultsCompared with HCs, female patients with MDD showed that one cluster with significantly decreased ALFF in the left middle occipital gyrus(L-MOG). Furtherly we founded depressed female subjects showed significantly lower FC between the L-MOG seed and left orbitofrontal cortex, and significantly higher FC between the L-MOG seed and left medial prefrontal gyrus and left hippocampus.ConclusionsOur results showed L-MOG may act as a connection, which involved in the processing of cognitive biases of MDD by connected with limbic-cortical regions in resting state. These findings may enhance the understanding of the neurobiological mechanism in female patients with MDD.

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“…63,64 Another edge that exhibited strong sFC differences was between the precuneus and a fronto-temporal node (IC7-IC16). Activity within the precuneus has been associated with increased number of depressive episode 65 and rumination 66 . Two other implicated nodes were the cerebellum (IC31) and the thalamus (IC39).…”

Section: Discussionmentioning

confidence: 99%

Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression

Maglanoc

Landrø

Jonassen

et al. 2018

Preprint

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Background: Depression is a complex disorder with large inter-individual variability in symptom profiles that often occur alongside symptoms of other psychiatric domains such as anxiety. A dimensional and symptom-based approach may help refine the characterization and classification of depressive and anxiety disorders and thus aid in establishing robust biomarkers. We assess the brain functional connectivity correlates of a symptom-based clustering of individuals using functional brain imaging data. Methods: We assessed symptoms of depression and anxiety using Beck's Depression andBeck's Anxiety inventories in individuals with or without a history of depression, and high dimensional data clustering to form subgroups based on symptom profiles. To assess the biological relevance of this subtyping, we compared functional magnetic resonance imagingbased dynamic and static functional connectivity between subgroups in a subset of the total sample. Results:We identified five subgroups with distinct symptom profiles, cutting across diagnostic boundaries and differing in terms of total severity, symptom patterns and centrality. For instance, inability to relax, fear of the worst, and feelings of guilt were among the most severe symptoms in subgroup 1, 2 and 3, respectively. These subgroups showed evidence of differential static brain connectivity patterns, in particular comprising a frontotemporal network. In contrast, we found no significant associations with clinical sum scores, dynamic functional connectivity or global connectivity measures. Conclusion:Adding to the ongoing pursuit of individual-based treatment, the results show subtyping based on a dimensional conceptualization and unique constellations of anxiety and depression symptoms is supported by distinct brain static functional connectivity patterns.

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Decreased Resting-State Activity in the Precuneus Is Associated With Depressive Episodes in Recurrent Depression

Cited by 54 publications

References 0 publications

Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Resting-state functional changes in the precuneus within first-episode drug-naive patients with MDD

Abnormal resting state activity of left middle occipital gyrus and its functional connectivity in female patients with major depressive disorder

Data-driven clustering reveals a link between symptoms and functional brain connectivity in depression

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