Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance

Fadaei, Reza; Kazemi, Tooba; Chamani, Elham; Azdaki, Nahid; Moezibady, Sayed Ali; Shahmohamadnejad, Shiva; Fallah, Soudabeh

doi:10.1016/j.cyto.2018.09.019

Cited by 49 publications

(58 citation statements)

References 24 publications

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“…Adipolin might play a role in this regard. In this study, there was an inverse relationship between this adipokine with fasting insulin and HOMA‐IR, which was similar to other studies in patients with diabetes and CAD . Experimental studies have shown that adipolin can improve glucose homeostasis and IR .…”

Section: Discussionsupporting

confidence: 91%

“…Serum adipolin had a negative correlation with TG and TG/HDL ratio in patients with diabetes and a positive association with HDL in CAD . In this study, adipolin showed a direct correlation with cholesterol and LDL serum concentrations.…”

Section: Discussionsupporting

confidence: 52%

“…Adipolin concentration was inversely associated with BMI, FBG, and waist‐to‐hip ratio . Another research has also shown decreased levels of adipolin in patients with CAD and its inverse association with IR and inflammation …”

Section: Discussionmentioning

confidence: 90%

“…10 Adipolin serum concentrations and subcutaneous adipose tissue mRNA expression and protein levels decreased significantly in women with PCOS compared to healthy controls. 11 Serum adipolin levels were also lower in patients with diabetes 12 and coronary artery disease (CAD) 13 compared to controls, and had negative correlation with IR and inflammatory markers. 12,13 However, little is known about the level of this peptide in advanced kidney failure and diabetes; disorders that are associated with considerable IR and metabolic challenges.…”

Section: Introductionmentioning

confidence: 99%

“…11 Serum adipolin levels were also lower in patients with diabetes 12 and coronary artery disease (CAD) 13 compared to controls, and had negative correlation with IR and inflammatory markers. 12,13 However, little is known about the level of this peptide in advanced kidney failure and diabetes; disorders that are associated with considerable IR and metabolic challenges. The aim of this study was to evaluate adipolin serum concentration and its relationship with IR, lipid profile, and anthropometries in patients with diabetes and/or hemodialysis.…”

Section: Introductionmentioning

confidence: 99%

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Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

Alipoor

Salmani

Yaseri

et al. 2019

Hemodialysis International

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Introduction Adipocytokines play a major role in obesity‐associated disorders like insulin resistance (IR). IR is prevalent in diabetes and advanced kidney failure. Adipolin is an adipocytokine with major beneficial effects on insulin sensitivity. This study aimed to investigate adipolin concentration and its relationship with IR and other cardiovascular risk factors in patients with diabetes and/or hemodialysis. Methods In this preliminary study, 24 obese patients with type 2 diabetes (DM) and 30 with hemodialysis (14 with diabetes and hemodialysis (HD/DM) and 16 with hemodialysis (HD/non‐DM)) were studied. Anthropometric indexes, serum concentrations of adipolin, fasting blood glucose (FBG), insulin, homeostatic model assessment of insulin resistance (HOMA‐IR), and lipid profile were assessed. Findings The results showed higher serum adipolin in DM (29 ± 35 ng/mL) than in HD/DM (13 ± 2 ng/mL, P = 0.01) and HD/Non‐DM (12 ± 1.6 ng/mL, P = 0.01) groups. Insulin level was lower in DM than HD/DM (P < 0.001) and HD/Non‐DM (P < 0.001) groups, and HOMA‐IR was also significantly lower in DM compared to HD/DM group (P < 0.001); while, FBG was significantly higher in DM (P < 0.001) and HD/DM (P = 0.006) compared to HD/Non‐DM patients. Adipolin was inversely associated with insulin level (r = −0.446, P = 0.001) and HOMA‐IR (r = −0.296, P = 0.035). LDL level was higher in DM compared to HD/DM (P = 0.008) and HD/Non‐DM (P = 0.005) groups. Adipolin was directly correlated with cholesterol (r = 0.348, P = 0.01) and LDL (r = 0.428, P = 0.001) concentrations. Discussion Higher adipolin level in DM group might indicate a compensatory elevation in adipolin production or secretion to modulate IR. It might also be due to medications and inflammation. Further studies are required to investigate the precise role of this adipokine in IR.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

Alipoor

Salmani

Yaseri

et al. 2019

Hemodialysis International

View full text Add to dashboard Cite

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CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF‐4α and DGAT2 expression

et al. 2020

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C1q/TNF-related protein 12 (CTRP12) is an antidiabetic adipokine whose circulating levels are reduced in obesity and diabetes. Although partial and complete loss-of-function mouse models suggest a role for CTRP12 in modulating lipid metabolism and adiposity, its effect on cellular lipid metabolism remains poorly defined. Here, we demonstrate a direct action of CTRP12 in regulating lipid synthesis and secretion. In hepatoma cells and primary mouse hepatocytes, CTRP12 treatment inhibits triglyceride synthesis by suppressing glycerophosphate acyltransferase (GPAT) and diacylglycerol acyltransferase (DGAT) expression. CTRP12 treatment also downregulates the expression of hepatocyte nuclear factor-4a (HNF-4a) and its target gene microsomal triglyceride transfer protein (MTTP), leading to reduced very-low-density lipoprotein (VLDL)-triglyceride export from hepatocytes. Consistent with the in vitro findings, overexpressing CTRP12 lowers fasting and postprandial serum triglyceride levels in mice. These results underscore the important function of CTRP12 in lipid metabolism in hepatocytes.

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CTRP12 ameliorates post-myocardial infarction heart failure through down-regulation of cardiac apoptosis, oxidative stress and inflammation by influencing the TAK1-p38 MAPK/JNK pathway

Bai

Wang

et al. 2023

Inflamm. Res.

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Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance

Cited by 49 publications

References 24 publications

Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

CTRP12 inhibits triglyceride synthesis and export in hepatocytes by suppressing HNF‐4α and DGAT2 expression

CTRP12 ameliorates post-myocardial infarction heart failure through down-regulation of cardiac apoptosis, oxidative stress and inflammation by influencing the TAK1-p38 MAPK/JNK pathway

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