Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

Alipoor, Elham; Salmani, Mahnaz; Yaseri, Mehdi; Kolahdouz‐Mohammadi, Roya; Esteghamati, Alireza; Hosseinzadeh‐Attar, Mohammad Javad

doi:10.1111/hdi.12787

Cited by 6 publications

(9 citation statements)

References 23 publications

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“…Serum adipolin levels in the present study were similar to those in some studies [14] and different from others [28]. The reason for this difference may be due to the influence of various factors, such as demographic differences, different conditions, underlying diseases, kit calibration, and other underlying disease-related factors.…”

Section: Discussionsupporting

confidence: 81%

“…The anti-atherosclerotic effects of adiponectin have been shown in many studies through various mechanisms, such as inhibition of adhesion of monocytes to the endothelial cells, foam cell formation of macrophages, and proliferation of vascular smooth muscle cells [26, 27]. Alipoor et al [28] also demonstrated the protective effects of adipolin on vascular remodeling by reducing the macrophage inflammatory response. Since this is the first study to indicate a link between CK-MB and CAD severity based on the Gensini score with serum adipolin levels, the precise mechanism of this association is unclear and needs further study.…”

Section: Discussionmentioning

confidence: 99%

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Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

et al. 2020

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Objective: Adipolin/C1q/TNF-related protein-12 is a family of CTRPs highly expressed in adipose tissue with glucose-lowering and anti-inflammatory effects. Various risk factors have been suggested in the incidence of cardiovascular diseases, such as a decrease in anti-inflammatory or an increase in inflammatory factors. The purpose of the present study was to investigate the correlation of adipolin with anthropometric, angiographic, echocardiographic, and biochemical parameters. Subject and Methods: A total of 90 patients who were candidates for angiography were included in the study and divided into 3 groups: 30 patients with acute myocardial infarction (AMI), 30 patients with stable angina pectoris (SAP), and 30 subjects as a control group with a history of chest pain but normal angiography. Anthropometric, angiographic, echocardiographic, and biochemical parameters were measured in all subjects. Results: Serum adipolin levels were significantly decreased in patients with AMI compared with the SAP and control groups (p < 0.001 for both). In addition, there was a negative association between serum levels of adipolin and epicardial fat thickness (EFT) and Gensini score in CAD patients. The results of multivariate linear regression analysis revealed that EFT values were independently associated with serum adipolin levels. Conclusion: The current study showed an independent association of adipolin with EFT for the first time in patients with AMI. Decreased adipolin levels in patients with AMI may be involved in the process of atherosclerosis, which requires further study.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

et al. 2020

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“…Adipolin was negatively associated with BMI and HOMA-IR, positively associated with adiponectin and HDL-C in these patients. (17,41,42) In our study, significantly decreased adipolin levels were observed in OB, MO and MetS groups in comparison to N-BMI group.…”

Section: Discussionsupporting

confidence: 58%

“…It exhibits anti-inflammatory effects. (16,17) Adropin is introduced as a fat-burning hormone with multiple functions. It also exhibits positive correlation with adiponectin.…”

Section: Introductionmentioning

confidence: 99%

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Donma¹,

Erselcan²,

Yılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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Technological advancements, unbalanced nutrition, sedentary life style, are important factors in obesity. Obesity-inflammation relationis beingexamined. In this study, the relationships among new generation inflammatory markers in children with normal body mass index (C) as well as obese (OB), morbid obese (MO) children and those with metabolic syndrome (MetS) were investigated. Materials and Methods: A total of 172 children participated in the study.Group 1 comprised children with normal body-mass index (control group) (C). Obese (OB) children were in Group 2, MO children constituted Group 3 and Group 4 included MO children with MetS. The number of cases were 37, 34, 51 and 50 in groups 1, 2, 3 and 4, respectively. Anthropometric measurements were recorded. Serum spexin, adropin, adipolipin, fibroblast growth factor-21 and fetuin-A levels were determined. Statistical analyses were performed. Result: Spexin and adipolin levels were significantly lower in obese groups than C group (p<0.05). Although adropin and FGF-21 levels did not differ significantly between groups, levels were lower in OB, MO, and MetS groups than C group.There were no significant differences among fetuin-A levels of the groups. Correlations between spexin and adipolin were the highest. These cytokines were negatively correlated with obesity parameters. The correlations between these cytokines were weakened from C group to MetS group. Conclusion: Decreasing spexin and adipolin levels in accordance with increasing obesity degrees and weakening of the correlation between these cytokines in MO group compared to C group may be helpful during the further investigation of obesity.

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“…The adipokines analyzed in this study-adipolin, chemerin, and neprilysin-were chosen due to their impact on tissue metabolism and insulin sensitivity [3,4]. Their mechanisms of action are not fully understood, and the results of studies determining the relationships between their blood concentrations and anthropometric and metabolic parameters in humans are inconclusive.…”

Section: Introductionmentioning

confidence: 99%

Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity

et al. 2023

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Adipolin, neprilysin, and chemerin have pleiotropic properties; therefore, their concentrations may influence health complications associated with obesity. The study aimed to search the relationship between adipokine levels and anthropometric and metabolic parameters as well as blood pressure values, taking into account the influence of gender and age. The study group consisted of 88 people aged 30–60 years. It was found that chemerin concentration is positively correlated with glycaemia in the 120′ OGTT (rs = 0.412; p = 0.030) in obese women. There was a negative correlation between adipolin and LDL-C serum concentration (rs = −0.414; p = 0.044) in obese individuals with normal glucose tolerance and a positive correlation between chemerin concentration and triglyceridemia (rs = 0.333; p = 0.033) in the men. Moreover, high chemerin levels (above median values) were observed 3.79 times more frequently (OR = 3.79; 95% CI: 1.03–13.91; p = 0.040) in the male population characterized by elevated triglyceride levels (above 1.7 mmol/L). In the logistic regression analyses, we found that the frequency of high plasma adipolin concentrations increases with age (p = 0.005) only in people with a BMI < 30 kg/m2. It was also shown that the concentrations of the studied adipokines are interrelated. Adipolin, neprilysin and chemerin concentrations are associated with selected anthropometric and metabolism exponents.

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Role of type 2 diabetes and hemodialysis in serum adipolin concentrations: A preliminary study

Cited by 6 publications

References 23 publications

Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

Correlation of Serum Adipolin with Epicardial Fat Thickness and Severity of Coronary Artery Diseases in Acute Myocardial Infarction and Stable Angina Pectoris Patients

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Adipolin, Chemerin, Neprilysin and Metabolic Disorders Associated with Obesity

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