Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis

Tomioka, Yukiko; Numata, Shusuke; Kinoshita, Makoto; Umehara, Hiroki; Watanabe, Shin; Nakataki, Masahito; Iwayama, Yoshimi; Toyota, Tomoko; Ikeda, Masashi; Yamamori, Hidenaga; Shimodera, Shinji; Tajima, Atsushi; Hashimoto, Ryota; Iwata, Nakao; Yoshikawa, Takeo; Ohmori, Tetsuro

doi:10.1503/jpn.170053

Cited by 31 publications

(31 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously demonstrated increased plasma tHcy and decreased serum vitamin B6 levels in schizophrenia. 4,9 Folate deficiency might be associated with schizophrenia by acting either through hyperhomocysteinemia and/or homocysteine-independent effects on neuronal progenitor division and/or altered one-carbon metabolism. 2 Two recent meta-analyses described lower peripheral blood levels of folate in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…We examined the relation between serum folate levels and plasma tHcy, and the relation between serum folate and vitamin B6 levels using data of the 1155 common participants from our previous studies. 4,9 The demographic characteristics of the 339 patients and 816 controls are presented in Table 2. In the 339 patients, the prevalence of low serum folate concentrations in male and female patients according to the control 10th percentile was 41.2% and 51.9%, respectively.…”

Section: Relations Among Folate Thcy and Vitamin B6 In Bloodmentioning

confidence: 99%

“…Growing evidence relating to the pathophysiology of schizophrenia indicates a potential effect of altered one-carbon metabolism, including epigenetic dysregulation. [1][2][3][4][5][6][7][8][9][10] Folate and related Bvitamins are involved in one-carbon metabolism and in the production of S-adenosylmethionine, a universal methyl donor required for various reactions, including the production of neurotransmitters. 11 To date, several studies have investigated the relation between blood folate levels and schizophrenia.…”

mentioning

confidence: 99%

“…We also examined the relations between serum folate levels, plasma total homocysteine (tHcy), and serum vitamin B6 (pyridoxal) levels using data of common participants from our previous studies. 4,9 Methods Participants A total of 482 patients with schizophrenia (282 men, mean age 58.5 AE 9.9 years; 200 women, mean age 59.6 AE 10.5 years) were recruited from Tokushima University Hospital, Japan, and its related psychiatric hospitals. Schizophrenia had been diagnosed by at least two expert psychiatrists based on the DSM-IV criteria, extensive clinical interviews with the patients, and a review of their medical records.…”

mentioning

confidence: 99%

“…A portion of the participants in the present study overlapped with those from our previous studies. 4,9 The current study was approved by the Ethics Committee of Tokushima University Hospital, and all enrolled participants provided their written informed consent. The study was conducted in accordance with the Declaration of Helsinki.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Association between serum folate levels and schizophrenia based on sex

Tomioka

Kinoshita

Umehara

et al. 2020

Psychiatry Clin Neurosci

Self Cite

View full text Add to dashboard Cite

Aim Sex differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on sex. With this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by sex. The relations among serum folate levels, plasma total homocysteine (tHcy), and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies. Methods The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on sex. Spearman's rank correlation was used to evaluate the relations among folate, tHcy, and vitamin B6 levels. Results In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort. Conclusion Our findings suggest that: (i) a low serum folate level may be associated with schizophrenia regardless of sex; and (ii) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Relations Among Folate Thcy and Vitamin B6 In Bloodmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Association between serum folate levels and schizophrenia based on sex

Tomioka

Kinoshita

Umehara

et al. 2020

Psychiatry Clin Neurosci

Self Cite

View full text Add to dashboard Cite

show abstract

Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA

Koshiyama

Miura

Nemoto

et al. 2020

Human Brain Mapping

Self Cite

View full text Add to dashboard Cite

Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta-Analysis (ENIGMA) consortium, an international neuroimaging consortium, established standard protocols for imaging analysis and employs either meta-and mega-analyses of psychiatric disorders with large sample sizes. The Cognitive Genetics Collaborative Research Organization (COCORO) in Japan promotes neurobiological studies in psychiatry and has successfully replicated and extended works of ENIGMA especially for neuroimaging studies. For example, (a) the ENIGMA consortium showed subcortical regional volume alterations in patients with schizophrenia (n = 2,028) compared to controls (n = 2,540) across 15 cohorts using meta-analysis. COCORO replicated the volumetric changes in patients with schizophrenia (n = 884) compared to controls (n = 1,680) using the ENIGMA imaging analysis protocol and mega-analysis. Furthermore, a schizophreniaspecific leftward asymmetry for the pallidum volume was demonstrated; and (b) the ENIGMA consortium identified white matter microstructural alterations in patients with schizophrenia (n = 1,963) compared to controls (n = 2,359) across 29 cohorts. Using the ENIGMA protocol, a study from COCORO showed similar results in patients with schizophrenia (n = 696) compared to controls (n = 1,506) from 12 sites using mega-analysis.Moreover, the COCORO study found that schizophrenia, bipolar disorder (n = 211) and autism spectrum disorder (n = 126), but not major depressive disorder (n = 398), share similar white matter microstructural alterations, compared to controls. Further replication and harmonization of the ENIGMA consortium and COCORO will contribute to the generalization of their research findings.

show abstract

Enhanced Molecular Appreciation of Psychiatric Disorders Through High-Dimensionality Data Acquisition and Analytics

Gastel

Hendrickx

Leysen

et al. 2019

Methods in Molecular Biology

View full text Add to dashboard Cite

Decreased serum pyridoxal levels in schizophrenia: meta-analysis and Mendelian randomization analysis

Abstract: We found decreased serum pyridoxal levels in patients with schizophrenia in this observational study. However, we failed to obtain data supporting a causal relationship between pyridoxal levels and schizophrenia risk using the MR approach.

Cited by 31 publications

References 40 publications

Association between serum folate levels and schizophrenia based on sex

Association between serum folate levels and schizophrenia based on sex

Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA

Enhanced Molecular Appreciation of Psychiatric Disorders Through High-Dimensionality Data Acquisition and Analytics

Contact Info

Product

Resources

About