Decreased Sound Tolerance in Tinnitus Patients

Raj-Koziak, Danuta; Gos, Elżbieta; Kutyba, Justyna; Skarżyński, Henryk

doi:10.3390/life11020087

Cited by 10 publications

(9 citation statements)

References 28 publications

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“…On the other hand, decreased sound tolerance was persistent in adolescents with normal hearing and tinnitus who did not recover during 1-year follow-up (8). To diagnose decreased sound tolerance, thorough history taking, audiological assessment, and psychological evaluation are necessary to exclude the possibility of misophonia (9). In a recent study, where tinnitus patients and a control group of patients with normal or symmetric hearing loss were enrolled, patients with unilateral tinnitus had significantly lower LDLs than the control group (10).…”

Section: Discussionmentioning

confidence: 99%

Audiological and psychological assessment of tinnitus patients with normal hearing

et al. 2023

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IntroductionThis study was performed to assess identifiable abnormalities in tinnitus patients with normal hearing.MethodsThe medical records of subjective non-pulsatile tinnitus patients with normal hearing confirmed by conventional pure-tone audiometry who visited our tinnitus clinic between March 2020 and May 2022 were reviewed. The loudness discomfort level (LDL), extended high-frequency hearing loss (EHFHL), summating potential (SP)/action potential (AP) ratio, distortion product otoacoustic emission (DPOAE), thresholds of auditory brainstem response (ABR) wave V, somatic modulation, and psychiatric symptoms, such as anxiety, depression, and stress were evaluated by questionnaires.ResultsDecreased LDL (n = 48, 59.8%) was the most frequent finding, followed by EHFHL (n = 29, 35.4%), increased SP/AP ratio (n = 27, 32.9%), psychiatric symptoms (n = 24, 29.3%), decreased DPOAE (n = 17, 20.7%), somatic modulation (n = 8, 9.8%), and increased ABR threshold (n = 3, 3.7%); 75.6% of patients had one or more of these findings. The presence of psychiatric symptoms was independently associated with the Tinnitus Handicap Inventory (THI) score.ConclusionTinnitus in patients with normal hearing may be accompanied by a combination of various subclinical abnormal audiological findings. However, the presence of psychiatric symptoms alone was independently associated with tinnitus distress.

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Section: Discussionmentioning

confidence: 99%

Audiological and psychological assessment of tinnitus patients with normal hearing

et al. 2023

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“…A major confound is that clinical studies are nearly entirely self-reported and based on patient reported outcomes over the last week or month. Large clinical studies have found a significant positive correlation between tinnitus and hyperacusis ( Cederroth et al, 2020 ; Raj-Koziak et al, 2021 ). Another study found that hyperacusis percept shows a positive correlation for the persistence of tinnitus ( Refat et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, a recent meta-analysis of clinical reports from the Cochrane library shows that tinnitus is one of the more common side effects for CF patients with recurrent AG treatments ( Smith et al, 2018 ). Hyperacusis is under-reported clinically but is known to be debilitating and comorbid with tinnitus ( Pienkowski et al, 2014 ), increasing with the number of years a patient has experienced tinnitus ( Raj-Koziak et al, 2021 ; Refat et al, 2021 ). Thus, it is important for AG-induced auditory dysfunctions to be further investigated in animal models to develop potential therapeutics for these diseases of maladaptive plastic change.…”

Section: Introductionmentioning

confidence: 99%

Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity

Longenecker¹,

Gu²,

Homan³

et al. 2021

Front. Mol. Neurosci.

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Aminoglycosides (AG) antibiotics are a common treatment for recurrent infections in cystic fibrosis (CF) patients. AGs are highly ototoxic, resulting in a range of auditory dysfunctions. It was recently shown that the acoustic startle reflex (ASR) can assess behavioral evidence of hyperacusis and tinnitus in an amikacin cochleotoxicity mouse model. The goal of this study was to establish if tobramycin treatment led to similar changes in ASR behavior and to establish whether ebselen can prevent the development of these maladaptive neuroplastic symptoms. CBA/Ca mice were divided into three groups: Group 1 served as a control and did not receive tobramycin or ebselen, Group 2 received tobramycin (200 mg/kg/s.c.) and the vehicle (DMSO/saline/i.p.) daily for 14 continuous days, and Group 3 received the same dose/schedule of tobramycin as Group 2 and ebselen at (20 mg/kg/i.p.). Auditory brainstem response (ABR) and ASR hearing assessments were collected at baseline and 2, 6, 10, 14, and 18 weeks from the start of treatment. ASR tests included input/output (I/O) functions which assess general hearing and hyperacusis, and Gap-induced prepulse inhibition of the acoustic startle (GPIAS) to assess tinnitus. At 18 weeks, histologic analysis showed predominantly normal appearing hair cells and spiral ganglion neuron (SGN) synapses. Following 14 days of tobramycin injections, 16 kHz thresholds increased from baseline and fluctuated over the 18-week recovery period. I/O functions revealed exaggerated startle response magnitudes in 50% of mice over the same period. Gap detection deficits, representing behavioral evidence of tinnitus, were observed in a smaller subset (36%) of animals. Interestingly, increases in ABR wave III/wave I amplitude ratios were observed. These tobramycin data corroborate previous findings that AGs can result in hearing dysfunctions. We show that a 14-day course of tobramycin treatment can cause similar levels of hearing loss and tinnitus, when compared to a 14-day course of amikacin, but less hyperacusis. Evidence suggests that tinnitus and hyperacusis might be common side effects of AG antibiotics.

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“…The ReSound Tinnitus Relief app was tested in our pilot study, and because of promising results, it was used again in this study [26,27]. The app was created in 2014 and is available on the Google Play Store and the App Store.…”

Section: Resound Tinnitus Relief Appmentioning

confidence: 99%

“…As the operation of the app on both platforms was the same, in our study we did not control which operating system the participants used. This particular app was chosen because it is free, has a menu in Polish, and has already been described in the literature [24,25,27,28]. The main function of the app is to generate various acoustic signals.…”

Section: Resound Tinnitus Relief Appmentioning

confidence: 99%

Chronic Tinnitus and the Positive Effects of Sound Treatment via a Smartphone App: Mixed-Design Study

Kutyba¹,

Jędrzejczak²,

Gos³

et al. 2022

JMIR Mhealth Uhealth

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Background Tinnitus is a phantom auditory sensation in the absence of an external stimulus. It is accompanied by a broad range of negative emotional symptoms and a significantly lower quality of life. So far, there is no cure for tinnitus, although various treatment options have been tried. One of them is mobile technology employing dedicated apps based on sound therapy. The apps can be managed by the patient and tailored according to their needs. Objective The study aims to assess the effect of a mobile app that generates background sounds on the severity of tinnitus. Methods The study involved 68 adults who had chronic tinnitus. Participants were divided into a study group (44 patients) and a control group (24 patients). For 6 months those in the study group used a free mobile app that enriched the sound environment with a background sound. Participants were instructed to use the app for at least 30 minutes a day using their preferred sound. The participants in the control group did not use the app. Subjective changes in the day-to-day functioning of both groups were evaluated using the Tinnitus Handicap Inventory (THI) questionnaire, a visual analog scale, and a user survey. Results After 3 months of using the app, the THI global score significantly decreased (P<.001) in the study group, decreasing again at 6 months (P<.001). The largest improvements were observed in the emotional and catastrophic reactions subscales. A clinically important change in the THI was reported by 39% of the study group (17/44). Almost 90% of the study participants (39/44) chose environmental sounds to listen to, the most popular being rain and ocean waves. In the control group, tinnitus severity did not change over 3 or 6 months. Conclusions Although the participants still experienced limitations caused by tinnitus, the advantage of the app was that it led to lower negative emotions and thus reduced overall tinnitus severity. It is worth considering whether a mobile app might be incorporated into the management of tinnitus in a professional setting.

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Decreased Sound Tolerance in Tinnitus Patients

Cited by 10 publications

References 28 publications

Audiological and psychological assessment of tinnitus patients with normal hearing

Audiological and psychological assessment of tinnitus patients with normal hearing

Development of Tinnitus and Hyperacusis in a Mouse Model of Tobramycin Cochleotoxicity

Chronic Tinnitus and the Positive Effects of Sound Treatment via a Smartphone App: Mixed-Design Study

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