Decreased survival in patients with carcinoma of axillary tail versus upper outer quadrant breast cancers: a SEER population-based study

Gou, Zong Chao; Liu, Xi Yu; Xiao, Yi; Jiang, Yi; Shao, Zhi Ming

doi:10.2147/cmar.s165291

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…In the present study, however, there was no significant difference in the number of tumors evaluated as T1 and T2/T3 in LN-positive and -negative groups ( p = 0.340), which was similar to the results of the previous study; that is, tumor size on ultrasound was not an independent predictor of axillary LN metastasis ( 28 ). Breast tumor location has been acknowledged as an independent factor of tumor prognosis, and malignant tumors in the lower inner quadrant were related to a worse prognosis because of the internal mammary lymphatic pathway without sufficient studies ( 32 ). However, there was no significant difference in tumor location ( p = 0.390) in LN-positive and -negative groups in our study.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Risk System Based on Shear Wave Elastography and BI-RADS Categories in Assessing Axillary Lymph Node Metastasis of Invasive Breast Cancer—A Multicenter Study

et al. 2022

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PurposeTo develop a risk stratification system that can predict axillary lymph node (LN) metastasis in invasive breast cancer based on the combination of shear wave elastography (SWE) and conventional ultrasound.Materials and MethodsA total of 619 participants pathologically diagnosed with invasive breast cancer underwent breast ultrasound examinations were recruited from a multicenter of 17 hospitals in China from August 2016 to August 2017. Conventional ultrasound and SWE features were compared between positive and negative LN metastasis groups. The regression equation, the weighting, and the counting methods were used to predict axillary LN metastasis. The sensitivity, specificity, and the areas under the receiver operating characteristic curve (AUC) were calculated.ResultsA significant difference was found in the Breast Imaging Reporting and Data System (BI-RADS) category, the “stiff rim” sign, minimum elastic modulusof the internal tumor and peritumor region of 3 mm between positive and negative LN groups (p < 0.05 for all). There was no significant difference in the diagnostic performance of the regression equation, the weighting, and the counting methods (p > 0.05 for all). Using the counting method, a 0–4 grade risk stratification system based on the four characteristics was established, which yielded an AUC of 0.656 (95% CI, 0.617–0.693, p < 0.001), a sensitivity of 54.60% (95% CI, 46.9%–62.1%), and a specificity of 68.99% (95% CI, 64.5%–73.3%) in predicting axillary LN metastasis.ConclusionA 0–4 grade risk stratification system was developed based on SWE characteristics and BI-RADS categories, and this system has the potential to predict axillary LN metastases in invasive breast cancer.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Risk System Based on Shear Wave Elastography and BI-RADS Categories in Assessing Axillary Lymph Node Metastasis of Invasive Breast Cancer—A Multicenter Study

et al. 2022

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“…We derived a dataset of female breast cancer patients diagnosed from 2010 to 2013, for the reason of known HER2 status and follow-up time. The inclusion criteria were as follows: females aged over 18 years old; American Joint Committee on Cancer stages (the seventh AJCC System) TNM stage I–III;21,22 unilateral breast cancer; breast cancer as the first and only cancer diagnosis; TCNP or tumor in the breast peripheral quadrant (TBPQ) (including UOQ, UIQ, lower outer quadrant, LIQ, but overlapping sites were excepted); diagnosis not obtained from a death certificate or autopsy; pathologic confirmation of breast cancer; known tumor differentiation status (histological score);23–25 known HR and HER2 status;26–28 known tumor size and LN status; known surgery type; known radiation/chemotherapy; and active follow-up. Patients with incomplete information were excluded.…”

Section: Methodsmentioning

confidence: 99%

<p>Tumor location of the central and nipple portion is associated with impaired survival for women with breast cancer</p>

Ji¹,

Xiao²,

Yang³

et al. 2019

CMAR

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Background Tumor location in the breast varies, with the highest frequency in the upper outer quadrant and lowest frequency in the lower inner quadrant. Nevertheless, tumors in the central and nipple portion (TCNP) are poorly studied types of breast cancer; therefore, we aimed to clarify the clinicopathological characteristics and prognostic features of TCNP. Methods Using the Surveillance, Epidemiology, and End Results database, we identifed 105,037 patients diagnosed with tumor in the breast peripheral quadrant (TBPQ) (n=97,046) or TCNP (n=7,991). The chi-squared test was used to compare categorical variables across TCNP and TBPQ. Cox proportional hazard models with hazard ratios were applied to estimate the factors associated with prognosis. Results The median follow-up was over 43 months. Compared with TBPQ, TCNP patients were signifcantly older (age ≥66 years: 40.4% vs 34.1%, P<0.001), with larger tumor sizes (>20 mm size: 46.9% vs 37.3%, P<0.001), higher proportions of TNM stage II–III (18.6% vs 9.9%, P<0.001), and more mastectomies (58.1% vs 37.8%, P<0.001). The breast cancer-specifc survival (BCSS)/overall survival (OS) rate was signifcantly worse for TCNP than for TBPQ. Multivariate Cox analysis showed a higher hazard ratios for TCNP over TBPQ (BCSS: hazard ratios =1.160, P=0.005, 95% CI: 1.046–1.287; OS: hazard ratios =1.301, P<0.001, 95% CI: 1.211–1.398). A subgroup analysis revealed inferior outcomes for TCNP in TNM stage II–III and breast subtype subgroup. Multivariate logistic regression indicated that TCNP was an independent contributing factor to LN metastasis. Conclusions TCNP was associated with older age, larger tumor size, higher TNM stage, and lymph node metastasis. Compared with TBPQ, TCNP had adverse impacts on BCSS and OS.

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“…It is usually detected in the early stages and is characterized by a lack of hormone receptors [ 4 , 7 , 8 ]. Compared to upper outer quadrant (UOQ) breast cancer, CATS has a higher grade, a higher rate of negative hormone receptors, and a greater tendency to spread to the lymph nodes, leading to a poorer prognosis [ 9 ]. In our case, a 46-year-old woman presented with advanced stage of CATS with bleeding and ulceration.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis for CATS depends on the stage when diagnosed. Compared to UOQ breast cancer, CATS has a lower 10-year breast cancer-specific survival (BCSS) rate, particularly in the metastatic lymph node and hormone receptor-negative subgroups [ 9 ]. The estimated five-year disease-free survival rate for CATS is 67 %.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma of the axillary tail of Spence: A rare case report

Kalita,

Gupta,

Sengupta

et al. 2024

International Journal of Surgery Case Reports

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Decreased survival in patients with carcinoma of axillary tail versus upper outer quadrant breast cancers: a SEER population-based study

Cited by 9 publications

References 21 publications

Comprehensive Risk System Based on Shear Wave Elastography and BI-RADS Categories in Assessing Axillary Lymph Node Metastasis of Invasive Breast Cancer—A Multicenter Study

Comprehensive Risk System Based on Shear Wave Elastography and BI-RADS Categories in Assessing Axillary Lymph Node Metastasis of Invasive Breast Cancer—A Multicenter Study

<p>Tumor location of the central and nipple portion is associated with impaired survival for women with breast cancer</p>

Carcinoma of the axillary tail of Spence: A rare case report

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