Decreased survival of C/EBPβ-deficient keratinocytes is due to aberrant regulation of p53 levels and function

C/EBPβ phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin

“…Phospho-C/EBP␤ could induce the inhibition of proapoptotic proteins, such as p53 (50), or the activation of survival proteins, such as MnSOD (37) or FLIP (8). Alternatively, granzyme B rather than caspase 8 could be the major target of C/EBP␤-phospho-T 217 , as we suggested previously for hepatic stellate cell apoptosis/survival (9).…”

Molecular Symbiosis of CHOP and C/EBPβ Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced Apoptosis

“…The contribution of the C/EBP␤ proteins to apoptotic cell death is still debated (3,12,51). In ER stress conditions, C/EBP␤ seems to fulfill proapoptotic roles (56); however, the contribution of the singular C/EBP␤ isoforms to the activation of the ER stress apoptotic program was thus far not addressed experimentally.…”

Induction of CCAAT/Enhancer-Binding Protein β Expression With the Phosphodiesterase Inhibitor Isobutylmethylxanthine Improves Myoblast Engraftment Into Dystrophic Muscle

“…Many approaches have been investigated to enhance myoblast survival upon transplantation, including hypoxia preconditioning; heat shock; and coinjection with small molecules (dextran sulfate), biomaterials (fibrin gel), or macrophages [46][47][48][49][50]. Interestingly, C/EBPb is a potent prosurvival factor [37,38] and is upregulated in several tumors, demonstrating its role as an important mediator of cell survival during tumorigenesis [30,38]. Thus, in addition to improving stem cell marker expression in myoblasts, IBMX treatment, through C/EBPb, appears to also improve transplantation outcomes through increased myoblast survival after grafting.…”

“…Interestingly, C/EBPb is a potent prosurvival factor that can both directly inhibit caspases through a XEXD box as well as inhibit p53 activity [37,38], and high Pax7 expression supports myoblast survival [39]. Equal numbers of WT or cKO myoblasts cultured with vehicle or IBMX for 5 days under growth conditions were stained with the vital dye carboxyfluorescein succinimidyl ester (CSFE) before transplantation into CTX-injured TA muscles of mdx mice.…”