Decreased Taste and Smell Acuity in Cirrhosis

Burch, Robert E.; Sackin, David A.; Ursick, John A.; Jetton, Mary M.; Sullivan, James F.

doi:10.1001/archinte.1978.03630290047017

Cited by 49 publications

(11 citation statements)

References 16 publications

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“…The role of Zn in taste perception has not been completely delineated [130]. Thus, in some studies Zn deficiency was not correlated with reduced taste acuity [126,127,131], while Zn supplementation in cirrhotic patients either did [132,133] or did not [126] increase taste perception compared with placebo.…”

Section: Correlations Between the Clinical Manifestations Of Zn Deficmentioning

confidence: 99%

Zinc and the Liver: An Active Interaction

2007

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Zinc is an essential trace element, exerting important antioxidant, anti-inflammatory, and antiapoptotic effects. It affects growth and development and participates in processes such as aging and cancer induction. The liver is important for the regulation of zinc homeostasis, while zinc is necessary for proper liver function. Decreased zinc levels have been implicated in both acute and chronic liver disease states, and zinc deficiency has been implicated in the pathogenesis of liver diseases. Zinc supplementation offers protection in experimental animal models of acute and chronic liver injury, but these hepatoprotective properties have not been fully elucidated. In the present review, data on zinc homeostasis, its implication in the pathogenesis of liver diseases, and its effect on acute and chronic liver diseases are presented. It is concluded that zinc could protect against liver diseases, although up to now the underlying pathophysiology of zinc and liver interactions have not been defined.

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Section: Correlations Between the Clinical Manifestations Of Zn Deficmentioning

confidence: 99%

Zinc and the Liver: An Active Interaction

2007

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“…This confirms previous findings reporting some degree of olfactory loss in cirrhosis patients. Burch et al [5] found elevated thresholds for three odorants in all investigated patients with cirrhosis. Other groups described an impairment of olfaction with an incidence between 24 and 100% [6][7][8].…”

Section: Discussionmentioning

confidence: 93%

“…Only a few older studies have investigated olfactory function [5][6][7][8][9], mostly because of the fact that olfaction has a major impact on the appreciation of foods, and thus on anorexia [10][11][12]. Although all of these studies reported chemosensory alterations, olfactory deficits are generally not listed among the major symptoms of liver cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Dysfunction of the liver affects the sense of smell

Temmel

Pabinger

Quint

et al. 2005

Wien Klin Wochenschr

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Although the reason for olfactory dysfunction in CL is far from clear, future investigations should focus on the hypothesis that endogenous intoxication may lead to a stronger deficit in the central-nervous processing of olfactory information than to peripheral lesions in the olfactory system. In addition, while more specific research is needed, olfactory dysfunction may serve as a subclinical indicator of hepatic encephalopathy.

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“…Re lated to this, one emerging tenet is that there is a stronger association between altered di etary habits or weight loss and dysgeusia than hypogeusia or shifts in taste preferences [90,91]. Liver Anorexia, dysgeusia and food aversions are common findings in patients with liver disease [92], Clinical studies have demon strated that patients with viral hepatitis and cirrhosis also develop hypogeusia [92][93][94][95]. Such patients display similarly elevated taste thresholds [93], suggesting that taste abnor malities may be associated with disorders of hepatic function in general, as opposed to pathology-specific complications.…”

Section: Large Bowelmentioning

confidence: 99%