Decreased Total Antioxidant Capacity in Plasma, but Not Tissue, in Experimental Colitis

Breganó, José Wander; Dichi, Jane Bandeira; Barbosa, Décio Sabbatini; Kadri, Mirian Zebian El; Matsuo, Tiemi; Rodrigues, Maria Aparecida Marchesan; Cecchini, Rúbens; Dichi, Isaías

doi:10.1007/s10620-008-0439-z

Cited by 8 publications

(2 citation statements)

References 38 publications

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“…In this study, a HFD resulted in a reduced level of TAC in serum but not in liver or testis tissue. Experimental colitis in rats has been reported to reduce serum TAC without effecting the TAC level in tissue (Breganó et al., ). Future work will involve assay of biomarkers for oxidative stress and antioxidant activity which could support our results.…”

Section: Discussionmentioning

confidence: 99%

Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

et al. 2018

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Nonalcoholic fatty liver disease (NAFLD) is associated with low testosterone levels in serum. The aim of this study was to evaluate the effect of apple vinegar on fertility indices in a rat model of NAFLD. To study this effect, 32 adult male rats were divided into four groups: A-normal diet, B-high-fat diet (HFD), C-apple vinegar and D-HFD plus apple vinegar. At the end of the week 22, the Lee index, serum lipid profiles, liver enzymes, glucose and total antioxidant levels (TAC) in serum were determined. In addition, liver and testis tissue homogenate, histopathology, serum testosterone and sperm parameters were measured and HOMA-IR calculated. Significant reduction in Lee index, serum triglyceride, cholesterol, liver enzymes and glucose levels was observed in vinegar treated group compared with HFD group. Vinegar lowered insulin resistance compared with HFD (p < 0.01). Steatosis in hepatocytes reduced from 56% in HFD group to 20% in group D (p < 0.05). Vinegar caused a significant increase in serum testosterone, improvement in sperm parameters and a reduced germ cell apoptosis (p < 0.05). There was an insignificant increase in TAC levels in the serum and homogenate tissue of liver and testis compared with HFD. This study reports apple vinegar has beneficial effects on male rat fertility indices in an in vivo model of NAFLD.

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Section: Discussionmentioning

confidence: 99%

Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

et al. 2018

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“…Lipid peroxidation caused by hydroxyl and superoxide radicals is the key reaction that damages the intestinal mucosa (10). Various animal models and human studies reveal an inverse relationship between antioxidant (AOX) enzyme (11,12) and MDA levels (13). There are many markers used for the evaluation of oxidative stress and antioxidant status (14).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Probiotic and Omega-3 Supplements on Total Oxidant and Total Antioxidant Levels in Experimental Colitis

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et al. 2021

Clinical and Experimental Health Sciences

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Objective: Treatment of inflammatory bowel disease (IBD) usually involves medical therapy. For this reason, it is recommended to seek alternative treatment methods such as nutritional therapy. The aim of the study is to evaluate the effects of probiotics and omega-3 fatty acids on total oxidant and total antioxidant levels in an experimental colitis model. Methods: Mice were randomly divided into five groups (n= 10/group) as healthy group, colitis group, group treated with probiotics (VSL#3), group treated with omega-3 (w-3), and group treated with both probiotics and omega-3. To induce experimental colitis, 200 mg/kg dinitrobenzene sulfonic acid (DNBS) + 30% ethanol combination was rectally administered to anesthetized mice. Total oxidant (TOS) and total antioxidant (TAS) levels were measured at the tissue level.Results: Lower concentrations of TOS were observed in the probiotics groups (2.11±0.23 mmol H2O2 Eq/L), probiotics+omega-3 (2.56±1.18 mmol H2O2 Eq/L), and omega-3 (3.02±1.88 mmol H2O2 Eq/L) groups compared to the colitis group (3.11±0.91 mmol H2O2 Eq/L) (p>0.05).Higher TOS and TAS level were observed in the control colitis group compared to other groups; however, the differences were not statistically significant. Conclusion:Our findings showed that TAS and TOS levels were positively affected by the use of probiotic supplements in IBD. It was determined that using w-3 alone was ineffective in decreasing TOS levels. Studies with higher dosages and longer treatment periods are needed to better observe the effects of nutritional supplements on TOS and TAS parameters in inflammatory bowel diseases.

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Development of a novel method for monitoring the antioxidative effect of ascorbic acid in rat blood

et al. 2012

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Decreased Total Antioxidant Capacity in Plasma, but Not Tissue, in Experimental Colitis

Cited by 8 publications

References 38 publications

Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

Beneficial effect of apple vinegar on reproductive parameters in male rat model of nonalcoholic fatty liver disease

The Effect of Probiotic and Omega-3 Supplements on Total Oxidant and Total Antioxidant Levels in Experimental Colitis

Development of a novel method for monitoring the antioxidative effect of ascorbic acid in rat blood

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