Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease

Fenkçi, Veysel; Fenkci, Semin; Yılmazer, Mehmet; Serteser, Mustafa

doi:10.1016/s0015-0282(03)00571-5

Cited by 271 publications

(199 citation statements)

References 51 publications

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“…20 This could explain the presence of oxidative stress even in the absence of obesity in our PCOS women. Our findings are in accordance with study done by Sabuncu T et al and Fenkci V et al 21,22 …”

supporting

confidence: 94%

“…[14][15][16] Oxidative stress was previously linked to obesity commonly seen in these PCOS women. 17,18 Oxidative stress has been implicated in a number of diseases such as cardiovascular disease, neurological disease, malignancies, renal disease, diabetes, inflammatory problems, skin diseases, aging, respiratory diseases, liver diseases and different types of viral infections. Recent studies have documented increased oxidative stress in patients with PCOS which may increase the risk of cardiovascular disease in such patients.…”

mentioning

confidence: 99%

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Oxidative stress versus inflammation, a better predictor of cardiovascular disease risk in polycystic ovary syndrome

et al. 2016

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supporting

confidence: 94%

mentioning

confidence: 99%

Oxidative stress versus inflammation, a better predictor of cardiovascular disease risk in polycystic ovary syndrome

et al. 2016

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“…Several studies have found lower TAS and FRAP values in obese persons than in nonobese persons 41,74 and animal models of obesity. 53 For example, FRAP values were 22% lower in obese than in nonobese matched controls, 41 and TAS values were moderately lower in obese persons (1.15 vs 1.30 mmol/l).…”

mentioning

confidence: 97%

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

2005

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Objective: Oxidative stress may be the unifying mechanism underlying the development of comorbidities in obesity. Evidence suggests that a clustering of sources of oxidative stress exists in obesity: hyperglycemia, hyperleptinemia, increased tissue lipid levels, inadequate antioxidant defenses, increased rates of free radical formation, enzymatic sources within the endothelium, and chronic inflammation. Method: This review provides a summary of the available evidence on systemic oxidative stress in humans and specific metabolic pathways by which obesity may elevate systemic oxidant stress. The authors suggest possible methods of reducing oxidative stress such as antioxidant supplementation, caloric restriction and/or physical activity and surgical intervention to combat free radicals and reduce adipose tissue. Results: Obesity is associated with oxidative stress and can be reduced with weight loss (regardless of exercise or surgery induced weight loss), caloric restriction or antioxidant rich diets. Conclusion: Oxidative stress levels are elevated in human obesity, and these levels are modifiable with various lifestyle modifications and surgical interventions.

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“…11 In recent years, the decreased antioxidant and increased oxidant activity have been reported in women having PCOS. 29,30 PON1, which support a protection from oxidative and peroxidative transformation has been identified in FF by proteomic analysis. [31][32][33] In a recently published systematic review and meta-analysis, it has been reported that the concentrations of several promoters and by-products of oxidative stress such as homocysteine and malondialdeyde were significantly increased, and some circulating antioxidant markers, such as PON1 activity and glutathione levels, were decreased in patients with PCOS compared with those controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Paraoxonase and Arylesterase Activities in Follicle Fluid of Females with PCOS in ICSI Cycle

Özdeğirmenci¹,

Dilbaz²,

Tohma³

et al. 2017

TJRMS

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A AB BS S T TR RA AC CT TO Ob bj je ec ct ti iv ve e: : The aim of our study was to compare the Paraoxonase (PON1) and arylesterase (ARES) activity in follicle fluids of infertile females with polycystic ovary syndrome (PCOS). M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 93 women who underwent assisted reproductive technologies (ART) using intra-cytoplasmic sperm injection (ICSI) were enrolled in this prospective study, of whom 46, with PCOS, comprised the study group, the remaining 47 women with MFI formed the control group. Women age, body mass index, (BMI) basal hormone levels, total follicle count, total oxidant status (TOS), total antioxidant status (TAS), PON1 and ARES activity, oxidative stress index (OSI), simulated paraoxonase (SPON) were compared between groups. R Re es su ul lt ts s: : There were no significant differences for average age, BMI, Day3-FSH, Day3-LH, Day3-E2 and total follicle count among groups. Also there were no statistically significant differences among groups in terms of TOS, TAS, PON1, SPON, ARES and OSI (p>0.05). C Co on nc cl lu us si io on n: : TOS, TAS, OSI, SPON, PON1 and ARES enzyme activities in follicular fluid of infertile females with PCOS are similar in those with male factor infertility.K Ke ey y W Wo or rd ds s: : Paraoxonase; arylesterase; follicular fluid; polycystic ovary syndrome; infertility Ö ÖZ ZE ET T A Am ma aç ç: : Çalışmamızdaki amacımız Poikistik Over Sendromu (PKOS) olan infertil kadınların folikül sıvılarındaki Paraksonaz (PON1) ve arilesteraz (ARES) aktivitelerinin karşılaştırılması. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Yardımcı üreme tekniği (YÜT) ile intra-sitoplazmik sperm enjeskiyonu (ICSI) uygulanan toplam 93 kadın, bu prospektif çalışmaya dahil edildi, bu kadınlardan PKOS'lu olan 46' sı çalışma grubunu ve sadece erkek faktörü bulunan geri kalan 47'si kontrol grubunu oluşturdu. Kadınalrın yaşı, vücut kitle indeksi (VKİ), bazal hormon seviyeleri, toplam folikül sayıları, total oksidan status (TOS), total antioksidan status (TAS), PON1 ve ARES aktiviteleri, oksidatif stres indeksi (OSİ), simüle edilmiş paraksonaz (SPON) gruplar arasında karşılaştırıldı. B Bu ul lg gu ul la ar r: : Gruplar arasında ortalama yaş, VKİ, 3. Gün FSH-LH-Estadiol seviyeleri ve total folikül sayıları açısından anlamlı bir fark yoktu. Ayrıca TOS, TAS, PON1, SPON, ARES ve OSI seviyeleri arasında anlamlı bir farklılık yoktu (p>0.05). S So on nu uç ç: : Folikül sıvısı içindeki TOS, TAS, OSI, SPON, PON1 ve ARES'in enzim aktiviteleri PKOS'lu kadınlarda ve erkek faktörü nedeniyle YÜT uygulanan kadınlarda benzerdi. Ya zış ma Ad re si/Cor res pon den ce:

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Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease

Cited by 271 publications

References 51 publications

Oxidative stress versus inflammation, a better predictor of cardiovascular disease risk in polycystic ovary syndrome

Oxidative stress versus inflammation, a better predictor of cardiovascular disease risk in polycystic ovary syndrome

Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans

Comparison of the Paraoxonase and Arylesterase Activities in Follicle Fluid of Females with PCOS in ICSI Cycle

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