Decreased vision as the initial presenting symptom of disseminated prostatic disease

Connell, Paul; Fennessy, K.; Elfiki, Tarek; Bogue, Conor O.; O’Reilly, Seamus; Fenton, Sinead

doi:10.1038/sj.eye.6702155

Cited by 2 publications

(3 citation statements)

References 6 publications

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“…9 Some reported cases mentioned the presence of diplopia or visual acuity decrease due to oculomotor palsy, choroidal metastasis or optic nerve infiltration as the initial feature of prostatic malignancy; however, in none of them an associated bilateral optic disc swelling with meningeal involvement causing dramatic visual loss has been described as was the case in our patient. 6 , 7 , 8 …”

Section: Discussionmentioning

confidence: 99%

“…Visual symptoms as the initial presentation is an extremely rare event in prostate cancer. Only a few cases have been reported where visual disturbances led to the diagnosis of a prostatic malignancy, and in none of them the presence of optic disc swelling associated to meningeal involvement was described as the leading cause of the visual acuity deficit 6 , 7 , 8 and none of the reviewed cases of LC and visual loss in Lanfranconi series were from prostate cancer. 4 …”

Section: Introductionmentioning

confidence: 99%

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Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report

Miranda

Guantay

Espósito

et al. 2022

American Journal of Ophthalmology Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report

Miranda

Guantay

Espósito

et al. 2022

American Journal of Ophthalmology Case Reports

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“…The choroidal tumor showed and maintained complete response to surgical castration and hormonal therapy. In the review of literature, 8 - 30 23 patients with metastasis of prostate cancer in the choroid were retrieved to answer a clinical question to what extent choroidal metastasis of prostate cancer would show response to hormonal therapy.…”

Section: Introductionmentioning

confidence: 99%

Prostate Cancer Detected by Choroidal Tumor and Complete Response to Hormonal Therapy: Case Report and Literature Review of 24 Patients With Choroidal Metastasis From Prostate Cancer

Matsuo¹,

Tanaka

Nakamura

et al. 2021

Journal of Investigative Medicine High Impact Case Reports

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Metastatic choroidal tumors derived from prostate cancer are rare. In this study, we report a patient who manifested a choroidal tumor as the initial presenting sign of prostate cancer and review 23 patients with choroidal metastasis of prostate cancer in the literature to answer a clinical question how the choroidal metastases would respond to hormonal therapy. A 73-year-old man presented with a choroidal tumor in the right eye. He was in good health and had no previous history except for current hemodialysis in 3 years due to chronic renal failure as a sequel to glomerulonephritis. With the diagnosis of a probable metastatic tumor, positron emission tomography was performed to disclose high-uptake sites in multiple bones, lymph nodes, and the prostate, together with multiple nodular lesions in bilateral lungs on computed tomography (CT) scan. Serum prostate-specific antigen (PSA) was elevated to 541 ng/mL, which supported prostate cancer as the primary site. He had degarelix injection, and the choroidal tumor resolved rapidly and became flat degeneration in a month. Prostate biopsy showed poorly differentiated adenocarcinoma, and he underwent surgical castration. He had no medication until 3 years later when he showed gradual increase of serum PSA up to 6.05 ng/mL and multiple bony metastases on CT scan. Bicalutamide, switched to enzalutamide and then to abiraterone, led to the undetectable level of serum PSA until the last visit with no relapse of the choroidal metastasis, 6.8 years after the initial visit. In the literature review of 24 patients with choroidal metastasis of prostate cancer, including this patient, 8 patients presented a choroidal tumor as the initial sign and the choroidal lesions mostly showed complete response to hormonal therapy. Among 13 patients who were frequently in the course of hormonal therapy, choroidal metastases showed complete or partial response to external beam radiation to the eye in 11 patients and episcleral plaque radiotherapy in 2 patients. In conclusion, metastatic choroidal tumors of prostate cancer would show good response to hormonal therapy when the therapy has not been initiated. Hormone-resistant choroidal metastases in the therapeutic course of prostate cancer could be managed successfully by external beam radiation to the eye.

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Decreased vision as the initial presenting symptom of disseminated prostatic disease

Cited by 2 publications

References 6 publications

Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report

Visual loss as the initial manifestation of an ignored disseminated prostate cancer: A case report

Prostate Cancer Detected by Choroidal Tumor and Complete Response to Hormonal Therapy: Case Report and Literature Review of 24 Patients With Choroidal Metastasis From Prostate Cancer

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