Decreases in retinol and retinol-binding protein during total parenteral nutrition in rats are not due to a vitamin A deficiency

Lespine, Anne; Périquet, B.; Jaconi, Stefano; Alexandre, M C; García, Jesús Felicidades; Ghisolfi, J; Thouvenot, J; Siegenthaler, Georges

doi:10.1016/s0022-2275(20)37454-x

Cited by 9 publications

(1 citation statement)

References 42 publications

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“…These discrepancies may be due to variations in study design and methodologies. The binding of RBP4 to retinol and TTR is affected by several factors, including serum retinol, vitamin A intake, the acute phase response, protein-energy malnutrition, and liver and renal diseases (82)(83)(84)(85). In addition, age, sex, BMI, body fat percentage, lipid variables, fasting blood glucose, physical activity, TTR, waist circumference, waist-tohip ratio, ethnicity, insulin concentration, intakes of SFAs and TGs, and blood pressure are potential covariates that should be adjusted to find the precise correlation between RBP4 and cytokines (86)(87)(88)(89).…”

Section: Rbp4 and Cvdmentioning

confidence: 99%

Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases

Zabetian-Targhi

Mahmoudi²,

Rezaei

et al. 2015

Advances in Nutrition

109

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Retinol binding protein 4 (RBP4), previously called retinol binding protein (RBP), is considered a specific carrier of retinol in the blood. It is also an adipokine that has been implicated in the pathophysiology of insulin resistance. RBP4 seems to be correlated with cardiometabolic markers in inflammatory chronic diseases, including obesity, type 2 diabetes, metabolic syndrome, and cardiovascular diseases (CVDs). It has recently been suggested that inflammation produced by RBP4 induces insulin resistance and CVD. The clinical relevance of this hypothesis is discussed in this review. Knowledge concerning the association of RBP4 with inflammation markers, oxidative stress, and CVDs as well as concerning the role of diet and antioxidants in decreasing RBP4 concentrations are discussed. Special attention is given to methodologies used in previously published studies and covariates that should be controlled when planning new studies on this adipokine.

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