Decursin and decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in human keratinocytes

Jin, Wook; Ho, Ngoc Anh Thu; Hong, Jeongpyo; Kim, Yoon Ju; Shin, Yungyeong; Lee, Hanki; Suh, Joo‐Won

doi:10.1016/j.bbrc.2018.04.031

Cited by 17 publications

(11 citation statements)

References 14 publications

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“…Other studies have shown that Ecursin has anti-inflammatory and immune-regulating effects (Han et al. 2018 ). In short, many underlying active ingredients of SD have showed certain anti-inflammatory and immune-regulating effects, which are related to the mechanism of allergy.…”

Section: Discussionmentioning

confidence: 96%

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Wang

et al. 2022

Pharmaceutical Biology

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Context Saposhnikovia divaricata (Turcz.) Schischk (Apiaceae) (SD) has various pharmacological activities, but its effects on type I allergy (TIA) have not been comprehensively studied. Objective This study evaluates the treatment and molecular mechanisms of SD against TIA. Materials and methods The effective components and action targets of SD were screened using TCMSP database, and allergy-related targets of SD were predicted using GeneCards and OMIM database. The obtained target intersections were imported into David database for GO analysis, and used R software to perform KEGG analysis. The RBL-2H3 cells sensitised by DNP-IgE/DNP-BSA were treated with different concentrations of SD (root decoction, 0.5, 1, and 2 mg/mL), prim- O -glucosylcimifugin (POG, 10, 40, and 80 μg/mL) and the positive control drug–ketotifen fumarate (KF, 30 μM) for 12 h, then subjected to cell degranulation and qPCR analysis. Results Eighteen active compounds of SD and 38 intersection targets were obtained: TIA-related signal pathways mainly include calcium signal pathway, PI3K–Akt signal pathway and MAPK signal pathway. Taking the β-Hex release rate of the model group as the base, the release rate of SD and POG in high dose groups were 43.79% and 57.01%, respectively, which were significantly lower than model group ( p < 0.01), and significantly lower than KF group (63.83%, p < 0.01, p < 0.05). SD and POG could down-regulate the expression of related proteins in the Lyn/Syk, PI3K/AKT and MAPK signalling pathways. Discussion and conclusion Saposhnikovia divaricata could inhibit IgE-induced degranulation of mast cells, providing a scientific basis for further research and clinical applications of SD in TIA treatment.

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Section: Discussionmentioning

confidence: 96%

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Wang

et al. 2022

Pharmaceutical Biology

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“…When the body is damaged, cells and tissues at the wound site will secrete a large number of wound healing growth factors. Growth factors are cytokines that stimulate cell growth activity and play an important role in the body wound repair process (16). Cytokines can attract fibroblasts and inflammatory cells into the wound, which promotes vascularization and cell proliferation of the wound (17).…”

Section: Discussionmentioning

confidence: 99%

Effect of oral mucosal transplantation on the expression of EGF and VEGF‑C during skin wound repair

Yang

Zhu

et al. 2019

Exp Ther Med

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This study evaluated the effects of oral mucosal transplantation on epidermal growth factor (EGF) and vascular endothelial growth factor C (VEGF-C) in skin wound repair. Sixty-four rats were randomly separated into group A, B, C and D (16 rats in each group). The right abdomen skin was excised 1, 3, 5 and 7 days after injury, respectively. Oral mucosa of the rat tongue was transplanted to the right abdomen skin. Fourteen days after the healing of the oral mucosa graft, the rat skin full-thickness model was prepared at the transplant site (the study group) and the contralateral site (the control group). Rats in each group were anesthetized and sacrificed at 1, 3, 5 and 7 days after injury. Expression of EGF and VEGF-C in skin tissue was detected by RT-qPCR and ELISA. At 3 days, expression levels of EGF and VEGF-C mRNA and protein in skin tissue were significantly higher than those at 1 day (P<0.05). At 5 days, expression levels of EGF and VEGF-C mRNA and protein in skin tissue were significantly higher than those at 3 days (P<0.05). At 7 days, expression levels of EGF mRNA and protein in skin tissue were significantly lower than those at 5 days (P<0.05), while VEGF-C levels were significantly increased (P<0.05). Expression levels of EGF and VEGF-C mRNA and protein in the skin tissue of the study group were significantly lower than those in the control group at all days (P<0.05). EGF and VEGF-C may be involved in scar formation, and play an important role in the process of skin wound repair.

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“…Coumarin (Sowndhararajan et al, 2017). Decursin and decurinol angelate were tested in vitro and demonstrated improved wound healing through upregulated transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in HaCaT human keratinocytes (Han et al, 2018).…”

Section: Japanese Angelica Rootmentioning

confidence: 99%

“…Coumarin derivatives are also in the root such as decursinol angelate (C 19 H 20 O 5 ; 328.1311), decursin (C 19 H 20 O 5 ; 328.1311), bergapten (C 12 H 8 O 4 ; 216.0423), or scopoletin (C 10 H 8 O 4 ; 192.0423) ( Sowndhararajan et al, 2017 ). Decursin and decurinol angelate were tested in vitro and demonstrated improved wound healing through upregulated transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in HaCaT human keratinocytes ( Han et al, 2018 ).…”

Section: Wound-healing Herbal Topical Therapies From Kampomentioning

confidence: 99%

Kampo herbal ointments for skin wound healing

Paul-Traversaz

Umehara²,

Watanabe³

et al. 2023

Front. Pharmacol.

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The management of skin wound healing problems is a public health issue in which traditional herbal medicines could play a determining role. Kampo medicine, with three traditionally used ointments, provides interesting solutions for these dermatological issues. These ointments named Shiunkō, Chuōkō, and Shinsen taitsukō all have in common a lipophilic base of sesame oil and beeswax from which herbal crude drugs are extracted according to several possible manufacturing protocols. This review article brings together existing data on metabolites involved in the complex wound healing process. Among them are representatives of the botanical genera Angelica, Lithospermum, Curcuma, Phellodendron, Paeonia, Rheum, Rehmannia, Scrophularia, or Cinnamomum. Kampo provides numerous metabolites of interest, whose content in crude drugs is very sensitive to different biotic and abiotic factors and to the different extraction protocols used for these ointments. If Kampo medicine is known for its singular standardization, ointments are not well known, and research on these lipophilic formulas has not been developed due to the analytical difficulties encountered in biological and metabolomic analysis. Further research considering the complexities of these unique herbal ointments could contribute to a rationalization of Kampo’s therapeutic uses for wound healing.

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Decursin and decursinol angelate improve wound healing by upregulating transcription of genes encoding extracellular matrix remodeling proteins, inflammatory cytokines, and growth factors in human keratinocytes

Cited by 17 publications

References 14 publications

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Network pharmacology-based analysis of the mechanism of Saposhnikovia divaricata for the treatment of type I allergy

Effect of oral mucosal transplantation on the expression of EGF and VEGF‑C during skin wound repair

Kampo herbal ointments for skin wound healing

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