Dedicated breast CT: state of the art—Part II. Clinical application and future outlook

Zhu, Yueqiang; O’Connell, Avice M; Ma, Yue; Liu, Aidi; Li, Haijie; Zhang, Yuwei; Zhang, Xiaohua; Ye, Zhaoxiang

doi:10.1007/s00330-021-08178-0

Cited by 31 publications

(28 citation statements)

References 87 publications

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“…CBBCT, as a new 3D breast imaging method, is superior to breast mammography (MG) in the coverage of the breast tissue and the comfort level during scanning (11)(12)(13)(14). However, standardized scan protocols and standardized CE-CBBCT acquisition protocols are still lacking (15).…”

Section: Discussionmentioning

confidence: 99%

CT values of contrast-enhanced CBBCT: A useful diagnostic tool for benign and malignant breast lesions

Wei

Yang

et al. 2023

Acta Radiol

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Background Computed tomography (CT) value studies of cone-beam breast CT (CBBCT) mainly focus on the enhancement value or enhancement rate, and there has been no study on the CT value (Hounsfield units [HU]) of the lesion itself. Purpose To investigate the CT values under contrast-enhanced CBBCT (CE-CBBCT) and non-contrast-enhanced CBBCT (NC-CBBCT) in scanning for the differential diagnosis of benign and malignant breast lesions. Material and Methods A retrospective analysis was performed on 189 cases of mammary glandular tissues that underwent NC-CBBCT and CE-CBBCT examination. The qualitative CT values of the lesions, standardized Δ(L-A), standardized Δ*(L - G), standardized Δ(L-A) (Post 1st-Pre), and standardized Δ*(L-G) (Post 2nd-Post 1st) between the benign and malignant groups were compared. Prediction performance was evaluated using receiver operating characteristic (ROC) curves. Results In total, 58 cases were included in the benign group, 79 cases were included in the malignant group, and 52 cases were included in the normal group. The best diagnostic thresholds of CT values for L (Post 1st-Pre), Δ(L-A) (Post 1st-Pre), and Δ*(L-G) (Post 1st-Pre) were 49.5, 44, and 64.8 HU, respectively. The Δ(L-A) Post-1st rate values of CBBCT had medium diagnostic efficacy (AUC = 0.74, sensitivity = 76.6%, specificity = 69.4%). Conclusion CE-CBBCT can improve the diagnostic efficiency of breast lesions compared with NC-CBBCT. The CT values (HU) of lesions do not need to be standardized with fat and can be directly used in clinical differential diagnosis. The first contrast phase (60 s) is recommended to reduce the radiation exposure.

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Section: Discussionmentioning

confidence: 99%

CT values of contrast-enhanced CBBCT: A useful diagnostic tool for benign and malignant breast lesions

Wei

Yang

et al. 2023

Acta Radiol

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“…CsI:Tl, CdTe). 91 Focusing on the clinical applications, DBCT has been tested in the breast diagnostic setting for lesion detection, breast density and lesion size assessment, breast lesion classification, staging, histopathological prediction, preoperative imaging, as well as evaluating response to treatment [92][93][94] (Fig. 2).…”

Section: X-ray-based Techniquesmentioning

confidence: 99%

“…Similarly, DBCT is being investigated for screening purposes. [92][93][94][95][96] Among the most significant findings, are the superior performance of DBCT compared to DM and DBT, [92][93][94] and the similar appearance of breast lesions on DBCT compared to MRI. 92,94 The potential of DBCT in detecting calcifications associated to malignancy has also been highlighted, however, with controversial results.…”

Section: X-ray-based Techniquesmentioning

confidence: 99%

“…[92][93][94][95][96] Among the most significant findings, are the superior performance of DBCT compared to DM and DBT, [92][93][94] and the similar appearance of breast lesions on DBCT compared to MRI. 92,94 The potential of DBCT in detecting calcifications associated to malignancy has also been highlighted, however, with controversial results. 95,96 Prospective and larger retrospective studies are needed to warrant the clinical value of DBCT, and particularly, to investigate if this technique may serve as an alternative screening tool.…”

Section: X-ray-based Techniquesmentioning

confidence: 99%

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New Approaches and Recommendations for Risk‐Adapted Breast Cancer Screening

Tsarouchi

Hoxhaj

Mann

2023

Magnetic Resonance Imaging

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Population‐based breast cancer screening using mammography as the gold standard imaging modality has been in clinical practice for over 40 years. However, the limitations of mammography in terms of sensitivity and high false‐positive rates, particularly in high‐risk women, challenge the indiscriminate nature of population‐based screening. Additionally, in light of expanding research on new breast cancer risk factors, there is a growing consensus that breast cancer screening should move toward a risk‐adapted approach. Recent advancements in breast imaging technology, including contrast material‐enhanced mammography (CEM), ultrasound (US) (automated‐breast US, Doppler, elastography US), and especially magnetic resonance imaging (MRI) (abbreviated, ultrafast, and contrast‐agent free), may provide new opportunities for risk‐adapted personalized screening strategies. Moreover, the integration of artificial intelligence and radiomics techniques has the potential to enhance the performance of risk‐adapted screening. This review article summarizes the current evidence and challenges in breast cancer screening and highlights potential future perspectives for various imaging techniques in a risk‐adapted breast cancer screening approach.Evidence Level1.Technical EfficacyStage 5.

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“…[3][4][5][6][7][8][9][10] Dedicated CT devices developed for breast assessment, using technologies, such as "cone beam" and "phase contrast," have shown promising results. [11][12][13][14] However, only few studies have evaluated the performance of conventional multide-tector CT (MDCT) devices in the evaluation of breast lesions (Table 1). [15][16][17][18][19][20][21][22] Recently, prone MDCT with dedicated breast protocol has been shown to be feasible and showed substantial agreement with MRI features in breast cancer patients.…”

mentioning

confidence: 99%

Iodinated Contrast Enhancement of Breast Cancer on Prone Multidetector Computed Tomography—Preliminary Findings

Felipe

Barbosa

Chojniak

et al. 2022

J Comput Assist Tomogr

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Dedicated breast CT: state of the art—Part II. Clinical application and future outlook

Cited by 31 publications

References 87 publications

CT values of contrast-enhanced CBBCT: A useful diagnostic tool for benign and malignant breast lesions

CT values of contrast-enhanced CBBCT: A useful diagnostic tool for benign and malignant breast lesions

New Approaches and Recommendations for Risk‐Adapted Breast Cancer Screening

Iodinated Contrast Enhancement of Breast Cancer on Prone Multidetector Computed Tomography—Preliminary Findings

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