Dedifferentiated liposarcoma of the gastroesophageal junction

Askan, Gokce; Bağcı, Pelin; Hameed, Meera; Baştürk, Olca

doi:10.5146/tjpath.2014.01297

Cited by 6 publications

(14 citation statements)

References 22 publications

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“…The subtype of liposarcoma strongly effects the likelihood and location of recurrence. Dedifferentiated liposarcomas, as seen in our patient, will present with local recurrence in 40% of all cases and with metastasis in 17% of all cases, which necessitates long-term follow-up [2]. In comparison, 30-47% of all well-differentiated liposarcomas present with local recurrence, while metastasis is almost unseen without prior dedifferentiation [5,12].…”

Section: Discussion/conclusionmentioning

confidence: 66%

“…Dual staining with MDM2 and CDK4 has been shown to be both sensitive and specific for dedifferentiated liposarcoma [9] and results from overexpression of the protein product from chromosomal amplification of the 12q13-15 region of the MDM2 and CDK4 oncogenes. Amplification of these genes can then be confirmed with FISH if diagnostic uncertainty remains [2].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…All four cases were managed with surgical resection. Complete surgical resection remains the gold standard of treatment for soft tissue sarcomas and currently provides the only chance for a cure [ 2 , 5 , 6 , 10 , 11 , 12 ]. Surgical specimens with positive margins are strongly correlated with disease recurrence and decreased overall survival [ 11 , 12 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

“…The World Health Organization recognizes four subtypes of liposarcomas based on pathological characteristics: atypical lipomatous tumor/well-differentiated liposarcoma, dedifferentiated liposarcoma, myxoid liposarcoma, and pleomorphic liposarcoma. Well-differentiated liposarcomas and dedifferentiated liposarcomas are the most common subtypes, most frequently occurring the extremities and the retroperitoneum [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…Primary liposarcomas of the esophagus are perhaps the most common with over 20 reported cases, followed by primary gastric liposarcomas with 15 cases reported in the literature [4,5]. Cases of primary liposarcomas have also been reported in the gastroesophageal junction and colon [2,6]. Primary duodenal liposarcomas appear to be among the rarest subtypes of gastrointestinal liposarcomas.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Primary Duodenal Liposarcoma

2020

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Soft tissue sarcomas are common neoplasms accounting for 1% of all adult malignancies; however, soft tissue sarcomas infrequently arise from the abdominal viscera. Many case reports discuss gastric and esophageal neoplasms. In the group of gastrointestinal liposarcomas, primary duodenal liposarcomas are among the rarest, with only three previous cases reported in the literature. Herein, we discuss a case of primary duodenal liposarcoma. A 59-year-old woman presented with symptoms consistent with anemia raising suspicion for an upper gastrointestinal bleed. Upper endoscopy revealed an ulcerated mass in the first portion of the duodenum. The patient underwent a segmental duodenal resection and distal gastrectomy with Roux-en-Y reconstruction. A diagnosis of dedifferentiated liposarcoma was rendered on the resected specimen. At 16 months' follow-up, the patient remains without evidence of disease recurrence. We have presented a case of primary duodenal liposarcoma, which is among the rarest locations for gastrointestinal sarcomas with only three previous reports in the literature. Liposarcomas should be included in the differential for submucosal masses of the duodenum.

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Section: Discussion/conclusionmentioning

confidence: 66%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Discussion/conclusionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A Case of Primary Duodenal Liposarcoma

2020

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Proximal Gastrectomy in a Case of Giant Gastric Liposarcoma and a 5-Year Follow-Up

2020

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Even though liposarcomas account for 10-20% of all mesenchymal malignancies, they are extremely rarely located in the stomach. We report the case of a female patient with gastric liposarcoma. CT revealed a giant hypoechogenic tumour subcardially on the posterior gastric wall. Endoscopic tumour resection by piecemeal technique was done, and a lipoma was confirmed on histopathological examination. A recurrent bleeding tumour was proven 6 weeks later. The patient underwent an open proximal gastrectomy with pyloroplasty, and liposarcoma was surprisingly revealed in the resected specimen, finally. Five years later, our patient had been without recurrence or any somatic difficulties. The CT finding of a submucosal fatty tumour with heterogeneous density within the gastric wall should raise the suspicion for liposarcoma. The goal is the surgical removal of the tumour with sufficient margins ensuring R0 resection.

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Laparoscopy-assisted trans gastric wedge resection: A safe treatment for gastric pyloric liposarcoma: a case report and literature review

Paredes¹,

Eom²,

Park³

et al. 2022

Preprint

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Background Gastric liposarcoma (GL) is extremely rare and radical surgery has been the conventional treatment, even in small tumors. Laparoscopic wedge resection has been reported worldwide forsubepithelial tumors of the stomach. Case Presentation The patient was an asymptomatic 63-year-old man presenting with a subepithelial gastric tumor. The esophagogastroduodenoscopy showed a 3 cm ulcerated soft tumor located in the posterior wall of the antrum just above the pylorus. Two preoperative biopsies were performed with a negative result for malignant neoplasm. Dynamic computerized tomography revealed 35x35mm well-defined pyloric mass with fat density. Despite the difficult location of the tumor, parenchyma-sparing surgery was performed. Surgery was initiated by a laparoscopic approach with four trocars. After the dissection of the greater omentum, the greater curvature and the posterior wall of the stomach were exposed. A gastrostomy was performed in the anterior wall of the antrum. Due to the difficulty in identifying the tumor location, a mini-laparotomy was conducted. After assessing the pylorus and section parameters, the tumor was extracted by gastrostomy and resected with a linear stapler. The patient was discharged after five days with no complications. The histological diagnosis was a well-differentiated liposarcoma. Resection margins were clear. The tumor cells tested negative for MDM2. No adjuvant therapy was indicated. The patient is alive without recurrence. Conclusions Despite its rarity, gastric liposarcoma should be respected for differential diagnosis. Minimally invasive wedge resection might be a suitable treatment even if the location is close to the pylorus.

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Dedifferentiated liposarcoma of the gastroesophageal junction

Cited by 6 publications

References 22 publications

A Case of Primary Duodenal Liposarcoma

A Case of Primary Duodenal Liposarcoma

Proximal Gastrectomy in a Case of Giant Gastric Liposarcoma and a 5-Year Follow-Up

Laparoscopy-assisted trans gastric wedge resection: A safe treatment for gastric pyloric liposarcoma: a case report and literature review

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