To constrain the giant pulse (GP) emission mechanism and test the model of Lyutikov for GP emission, we have carried out a campaign of simultaneous observations of the Crab pulsar at γ -ray (Fermi) and radio (Green Bank Telescope) wavelengths. Over 10 hr of simultaneous observations we obtained a sample of 2.1 × 10 4 GPs, observed at a radio frequency of 9 GHz, and 77 Fermi photons, with energies between 100 MeV and 5 GeV. The majority of GPs came from the interpulse (IP) phase window. We found no change in the GP generation rate within 10-120 s windows at lags of up to ±40 minutes of observed γ -ray photons. The 95% upper limit for a γ -ray flux enhancement in pulsed emission phase window around all GPs is four times the average pulsed γ -ray flux from the Crab. For the subset of IP GPs, the enhancement upper limit, within the IP emission window, is 12 times the average pulsed γ -ray flux. These results suggest that GPs, at least high-frequency IP GPs, are due to changes in coherence of radio emission rather than an overall increase in the magnetospheric particle density.