Deep Brain Stimulation- A Novel Approach For Relieving Neurological Disorders: A Review

Gautam, Archana; Rai, Mansi; Srivastava, Rahul; jyoti, Bhuvan; Priyadarshi, Pankaj Kumar

doi:10.21276/ijcmsr.2018.3.3.19

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…It is an established treatment option that involves the placement into the brain of a medical device, also called "brain pacemaker," for the improvement of motor problems associated with PD, essential tremor, and dystonia, [45] as well as conditions including, but not limited to, epilepsy and clinical depression. [46,47] Pulses that mimic the natural flow of impulses are used to electrically stimulate neural pathways of specific areas of the brain (typically the motor cortex or cerebellum) [46] providing motor function restoration, improvement in quality of life, and adequate control of movements in PD patients. However, this treatment is not suitable for every patient and thus, its success depends on the patient's condition.…”

Section: Deep Brain Stimulationmentioning

confidence: 99%

The Future of Neuroscience: Flexible and Wireless Implantable Neural Electronics

et al. 2021

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Neurological diseases are a prevalent cause of global mortality and are of growing concern when considering an ageing global population. Traditional treatments are accompanied by serious side effects including repeated treatment sessions, invasive surgeries, or infections. For example, in the case of deep brain stimulation, large, stiff, and battery powered neural probes recruit thousands of neurons with each pulse, and can invoke a vigorous immune response. This paper presents challenges in engineering and neuroscience in developing miniaturized and biointegrated alternatives, in the form of microelectrode probes. Progress in design and topology of neural implants has shifted the goal post toward highly specific recording and stimulation, targeting small groups of neurons and reducing the foreign body response with biomimetic design principles. Implantable device design recommendations, fabrication techniques, and clinical evaluation of the impact flexible, integrated probes will have on the treatment of neurological disorders are provided in this report. The choice of biocompatible material dictates fabrication techniques as novel methods reduce the complexity of manufacture. Wireless power, the final hurdle to truly implantable neural interfaces, is discussed. These aspects are the driving force behind continued research: significant breakthroughs in any one of these areas will revolutionize the treatment of neurological disorders.

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