Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

Anderson, Robert; Frye, Mark A.; Abulseoud, Osama A.; Lee, Kendall H.; McGillivray, Jane; Berk, Michael; Tye, Susannah J.

doi:10.1016/j.neubiorev.2012.06.001

Cited by 129 publications

(67 citation statements)

References 203 publications

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“…In addition, studies evaluating brain structure using MRI have shown abnormalities in frontal regions and the cingulate gyrus, specifically, reduced volume and gray matter thickness in these areas in patients with MDD and bipolar disorder (Coryell et al, 2005;Lyoo et al, 2004;Nugent et al, 2006). These regions are thought to be part of a limbic-cortical-striatalpallidal-thalamic network that is involved in emotion processing (Anderson et al, 2012;Nugent et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Quraan

Protzner

Daskalakis

et al. 2013

Neuropsychopharmacol

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Recently, deep brain stimulation (DBS) has been evaluated as an experimental therapy for treatment-resistant depression. Although there have been encouraging results in open-label trials, about half of the patients fail to achieve meaningful benefit. Although progress has been made in understanding the neurobiology of MDD, the ability to characterize differences in brain dynamics between those who do and do not benefit from DBS is lacking. In this study, we investigated EEG resting-state data recorded from 12 patients that have undergone DBS surgery. Of those, six patients were classified as responders to DBS, defined as an improvement of 50% or more on the 17-item Hamilton Rating Scale for Depression (HAMD-17). We compared hemispheric frontal theta and parietal alpha power asymmetry and synchronization asymmetry between responders and non-responders. Hemispheric power asymmetry showed statistically significant differences between responders and non-responders with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry was characterized by an increase in frontal theta in the right hemisphere relative to the left combined with an increase in parietal alpha in the left hemisphere relative to the right in non-responders compared with responders. Hemispheric mean synchronization asymmetry showed a statistically significant difference between responders and non-responders in the theta band, with healthy controls showing an asymmetry similar to responders but opposite to non-responders. This asymmetry resulted from an increase in frontal synchronization in the right hemisphere relative to the left combined with an increase in parietal synchronization in the left hemisphere relative to the right in non-responders compared with responders. Connectivity diagrams revealed long-range differences in frontal/central-parietal connectivity between the two groups in the theta band. This pattern was observed irrespective of whether EEG data were collected with active DBS or with the DBS stimulation turned off, suggesting stable functional and possibly structural modifications that may be attributed to plasticity.

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Section: Introductionmentioning

confidence: 99%

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Quraan

Protzner

Daskalakis

et al. 2013

Neuropsychopharmacol

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“…2) indicated particularly high current density in one area of the limbic system: the anterior cingulate cortex (ACC). Levels of ACC activity have been correlated with severity of depressive symptoms and treatment outcomes (Downey et al 2016;Mayberg et al 1997;Osuch et al 2000), and deep brain stimulation of the ACC has demonstrated amelioration from treatment resistant depression (Anderson et al 2012;Holtzheimer and Mayberg 2012;Mayberg 2009).…”

Section: Discussionmentioning

confidence: 99%

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

et al. 2017

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second-daily (n = 21). In a second experiment, we separately investigated the influence of reversed polarity upon these same measures, in response to acute stimulation (n = 23) and repeated stimulation (n = 11). We observed a systematic elevation of mood in both active conditions following single and repeated tDCS, the latter of which displayed a progressive elevation of mood from baseline. No mood change was noted in response to either single or repeated stimulation in the sham condition. Frontocerebellar tDCS stimulation advantageously influences mood in healthy participants, with an accumulative and potentiated effect following successive stimulations. The possibility that frontocerebellar stimulation may provide a novel therapeutic adjunctive or pre-emptive intervention in stress-related disorders and mood-related psychopathologies should be considered.

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“…[116]. DBS can also be used in research studies of major depression [117,118] and other affective disorders [119], as well as in treatment of chronic pain [120,121], though none of these newer indications have been approved by FDA till now, which may probably due to high complication rates and side effects.…”

Section: Clinical Studies Of Deep Brain Stimulationmentioning

confidence: 99%

Chemical and Physical Approaches for the Treatment of Alzheimer's Disease

Li¹,

Zhou²,

Wu³

et al. 2015

ADMET DMPK

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Deep brain stimulation for treatment-resistant depression: Efficacy, safety and mechanisms of action

Cited by 129 publications

References 203 publications

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Acute and repetitive fronto-cerebellar tDCS stimulation improves mood in non-depressed participants

Chemical and Physical Approaches for the Treatment of Alzheimer's Disease

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