Deep Brain Stimulation of the Nucleus Accumbens Shell Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking in Rats: Figure 1.

Vassoler, Fair M.; Schmidt, Heath D.; Gerard, Melinda; Famous, Katie R.; Ciraulo, Domenic A.; Kornetsky, Conan; Knapp, Clifford M.; Pierce, R. Christopher

doi:10.1523/jneurosci.5277-07.2008

Cited by 173 publications

(148 citation statements)

References 40 publications

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“…So far, no lesion or DBS studies within a single brain structure have reported such an opposite dissociation. Although DBS applied at a fixed intensity for all animals in the nucleus accumbens shell has been recently reported to diminish cocaine-seeking behavior in a reinstatement experiment, there was no increase on food seeking (27). Consistent with a possible dissociation between natural reward and drugs of abuse, specific subpopulations of neurons in the nucleus accumbens have been proposed to encode either cocaine or sucrose reward (28).…”

Section: Discussionmentioning

confidence: 96%

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Rouaud

Lardeux

Panayotis

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

186

131

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Deep brain stimulation (DBS) is a reversible technique that is currently used for the treatment of Parkinson disease and may be suitable for the treatment of psychiatric disorders. Whether DBS inactivates the target structure is still a matter of debate. Here, from findings obtained in rats, we propose DBS of the subthalamic nucleus (STN) as a possible treatment for cocaine addiction to be further tested in human studies. We show that STN DBS reversibly reduces the motivation to work for an i.v. injection of cocaine, and it increases motivation to work for sucrose pellets. These opposite effects may result from STN DBS effect on the positive affective properties of these rewards. Indeed, we further show that STN DBS reduces the preference for a place previously associated with the rewarding properties of cocaine, and it increases the preference for a place associated with food. Because these findings are consistent with those observed after STN lesions [Baunez C, Dias C, Cador M, Amalric M (2005) Nat Neurosci 8:484-489], they suggest that STN DBS mimics an inactivation of the STN on motivational processes. Furthermore, given that one of the major challenges for cocaine addiction is to find a treatment that reduces the craving for the drug without diminishing the motivation for naturally rewarding activities, our findings validate STN as a good target and DBS as the appropriate technique for a promising therapeutic strategy in the treatment of cocaine addiction.O ver the past decade, there has been an increasing interest in neurosurgical procedures using deep brain stimulation (DBS) to treat neurological and psychiatric disorders, such as Parkinson disease (1, 2) and Huntington disease (3), as well as depression (4) and obsessive compulsive disorders (5).A recent study showing that the effects of subthalamic nucleus (STN) DBS mainly result from a stimulation of the cortico-STN fibers questioned the inactivation of STN by DBS (6). However, there was previously a consensus to consider that action of STN DBS as an inactivation of the cell bodies of the targeted structure with an activation of the passing fibers (7). The mechanisms of DBS remain thus a matter of debate.From the clinical point of view, DBS represents a reversible way to inactivate a particular structure in the brain, a strategy that is preferred to ablative surgery in most cases. The choice of the targeted structure is adapted to the disease.In the case of drug addiction, a devastating disorder whose hallmark feature is an uncontrolled motivation to take the drug while naturally rewarding activities are forsaken, it is crucial to decrease the compulsive motivation for the drug, at the same time preventing decreased motivation for alternative rewarding activities.Because cocaine acts by blocking the dopaminergic transporter, and therefore temporarily increases the amount of dopamine (DA) available in the brain, early treatments for addiction targeted DA system to counteract cocaine effects. However, it is now largely accepted that interfering with the ...

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Section: Discussionmentioning

confidence: 96%

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Rouaud

Lardeux

Panayotis

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

186

131

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“…Animal studies showed no effect on drugrelated behaviors after stimulation of the dorsal striatum 193 and lateral hypothalamus. 114 Lateral habenula stimulation was effective in controlling drug consumption but also decreased food consumption, which was considered an undesirable side effect.…”

Section: Addictionmentioning

confidence: 95%

“…100 Several preclinical studies in rats have investigated the effect of high-frequency DBS on ethanol consumption and cocaine/narcotic-seeking behavior. 15,79,92,165,193 These studies showed a significant reduction in drugseeking behaviors following DBS.…”

Section: Addictionmentioning

confidence: 96%

Deep brain stimulation: a mechanistic and clinical update

Karas

Mikell

Christian

et al. 2013

FOC

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Deep brain stimulation (DBS), the practice of placing electrodes deep into the brain to stimulate subcortical structures with electrical current, has been increasing as a neurosurgical procedure over the past 15 years. Originally a treatment for essential tremor, DBS is now used and under investigation across a wide spectrum of neurological and psychiatric disorders. In addition to applying electrical stimulation for clinical symptomatic relief, the electrodes implanted can also be used to record local electrical activity in the brain, making DBS a useful research tool. Human single-neuron recordings and local field potentials are now often recorded intraoperatively as electrodes are implanted. Thus, the increasing scope of DBS clinical applications is being matched by an increase in investigational use, leading to a rapidly evolving understanding of cortical and subcortical neurocircuitry. In this review, the authors discuss recent innovations in the clinical use of DBS, both in approved indications as well as in indications under investigation. Deep brain stimulation as an investigational tool is also reviewed, paying special attention to evolving models of basal ganglia and cortical function in health and disease. Finally, the authors look to the future across several indications, highlighting gaps in knowledge and possible future directions of DBS treatment.

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“…The translation of the results in human medicine is possible, if the models are valid. Some recent studies proved model validity in OCD (Mundt et al, 2009;Klavier et al, 2009;Klavier, Winter & Joel, 2011;Djodari-Irani et al, 2010;, depression , and substance dependency (Vassoler et al, 2008;Rouaud et al, 2010) (for overview see Winter, Harnack & Kupsch, 2010).…”

Section: Fourth Approach: Translational Researchmentioning

confidence: 99%

Deep Brain Stimulation in Schizophrenia

et al. 2014

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Deep brain stimulation (DBS) has successfully advanced treatment options of putative therapy-resistant neuropsychiatric diseases. Building on this strong foundation more and more mental disorders in the stadium of therapy-resistance are considered as possible indications for DBS. Especially schizophrenia with its associated severe and difficult to treat symptoms is gaining attention. This attention demands critical questions regarding the assumed mechanisms of DBS and its possible influence on the supposed pathophysiology of schizophrenia. Here we synoptically compare current approaches and theories of DBS and discuss the feasibility of DBS in schizophrenia as well as the transferability from other psychiatric disorders successfully treated with DBS. For this we consider recent advances in animal models of schizophrenic symptoms, results regarding the influence of DBS on dopaminergic transmission as well as data concerning neural oscillation and synchronization. In conclusion the use of DBS for some symptoms of schizophrenia seems to be a promising approach, but the lack of a comprehensive theory of the mechanisms of DBS as well as its impact on schizophrenia might void the use of DBS in schizophrenia at this point.

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Deep Brain Stimulation of the Nucleus Accumbens Shell Attenuates Cocaine Priming-Induced Reinstatement of Drug Seeking in Rats: Figure 1.

Cited by 173 publications

References 40 publications

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Reducing the desire for cocaine with subthalamic nucleus deep brain stimulation

Deep brain stimulation: a mechanistic and clinical update

Deep Brain Stimulation in Schizophrenia

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