Deep Brain Stimulation of the Internal Globus Pallidus Improves Response Initiation and Proactive Inhibition in Patients With Parkinson’s Disease

Pan, Yixin; Wang, Linbin; Zhang, Yingying; Zhang, Chencheng; Qiu, Xian; Tan, Yuyan; Zhou, Haiyan; Sun, Bo; Li, Dianyou

doi:10.3389/fpsyg.2018.00351

Cited by 13 publications

(8 citation statements)

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“…Many researchers have studied DBS in PD patients but only considered behavior, reaction time, symptom cognition, and mood with which to demonstrate therapeutic effect. 7,42 We verified the effect upon neurotransmitters and neural discharge at the level of the neurons. DBS influenced the release of neurotransmitters and spike firing characteristics, in CPU based on the basal ganglia circuit (BG).…”

Section: ■ Discussionmentioning

confidence: 81%

Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson’s Disease

et al. 2019

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Little is known about the efficacy of deep brain stimulation (DBS) as an effective treatment for Parkinson’s Disease (PD) because of the lack of multichannel neural electrical and chemical detection techniques at the cellular level. In this study, a 7-mm-long and 250-μm-wide microelectrode array (MEA) was fabricated to provide real-time monitoring of dopamine (DA) concentration and neural spike firings in the caudate putamen (CPU) of rats with PD. Platinumn nanoparticles and reduced graphene oxide nanocomposites (Pt/rGO) were modified onto the sensitive microelectrode sites. The detection limit (50 nM) and sensitivity (8.251 pA/μM) met the specific requirements for DA detection in vivo. A single neural spike was isolated due to the high signal-to-noise ratio of the MEA. DBS was applied in the affected side of the globus pallidus internal (GPi) in PD rats. After DBS, the concentration of DA in the bilateral CPU increased markedly. The mean increment of the ipsilateral DA was 7.33 μM (increasing from 0.54 μM to 7.87 μM), which was 2.2-fold higher than the increment in the contralateral side. The mean amplitude of neural spikes in the bilateral CPU decreased more than 10%, and was more obvious in the ipsilateral side where the spike amplitude changed from 169 μV to 134 μV. Spike firing rate decreased by 65% (ipsilateral side) and 51% (contralateral side). The power of the local field potential decreased to 940 μW (ipsilateral side) and 530 μW (contralateral side) in 0–30 Hz. Collectively, our data show that the GPi-DBS plays a significant regulatory role in the bilateral CPU in terms of DA concentration, spike firing, and power; furthermore, the ipsilateral variations of the dual mode signals were more significant than those in the contralateral side. These results provide new detection and stimulation technology for understanding the mechanisms underlying Parkinson’s disease and should, therefore, represent a useful resource for the design of future treatments.

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Section: ■ Discussionmentioning

confidence: 81%

Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson’s Disease

et al. 2019

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“…As a common structure within multiple basal ganglia pathways (direct, indirect, hyperdirect), it is involved in inhibitory control, but has been less studied than STN. Current evidence suggest a positive effect of GPi‐DBS in triggering the action, with no impairment in its suppression (Kohl et al, 2015 ), or even an improvement of the dysfunctional proactive inhibition after turning GPi stimulator ON (Pan et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Proactive inhibition is not modified by deep brain stimulation for Parkinson's disease: An electrical neuroimaging study

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et al. 2021

Human Brain Mapping

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In predictable contexts, motor inhibitory control can be deployed before the actual need for response suppression. The brain functional underpinnings of proactive inhibition, and notably the role of basal ganglia, are not entirely identified. We investigated the effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in patients with Parkinson's disease. They completed a cued go/no-go proactive inhibition task ON and (unilateral) OFF stimulation while EEG was recorded. We found no behavioural effect of either subthalamic nucleus or internal globus pallidus deep brain stimulation on proactive inhibition, despite a general improvement of motor performance with subthalamic nucleus stimulation. In the non-operated and subthalamic nucleus group, we identified periods of topographic EEG modulation by the level of proactive inhibition. In the subthalamic nucleus group, source estimation analysis suggested the initial involvement of bilateral frontal and occipital areas, followed by a right lateralized fronto-basal network, and finally of right premotor and left parietal regions. Our results confirm the overall preservation of proactive inhibition capacities in both subthalamic nucleus and internal globus pallidus deep brain stimulation, and suggest a partly segregated network for proactive inhibition, with a preferential recruitment of the indirect pathway.

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“…, adjustment of the action strategy in advance, according to the environment in which the stop signal will appear) ( Aron, 2011 ; Mirabella, 2021 ). Although Parkinson’s disease (PD) causes obvious motor inhibition defects ( Gauggel, Rieger & Feghoff, 2004 ; Bokura, Yamaguchi & Kobayashi, 2005 ; Antonelli, Ray & Strafella, 2010 ; Wylie et al, 2010 ; Obeso et al, 2011 ; Bloemendaal et al, 2018 ; Pan et al, 2018 ), no consensus has been reached regarding the specific manifestations of these defects in patients with the disease. Some researchers believe that PD is associated with poor proactive and reactive inhibition ( Obeso et al, 2013 ; Jana et al, 2020 ), whereas others found that this defect appears only in reactive inhibition control ( Di Caprio et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Selective effects of exercise on reactive and proactive inhibition in Parkinson’s disease

Zhen

et al. 2022

PeerJ

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Objective Patients with Parkinson’s disease (PD) have an obvious motor inhibition disorder, which is closely related to their motor symptoms. Although previous studies have shown that exercise can improve their inhibition deficits, the effect of exercise on different types of inhibition (proactive and reactive inhibition) has not been addressed. Methods We used a behavioral paradigm combined with a series of questionnaires to explore the effect of long-term exercise on different types of motor inhibition in 59 patients with PD aged 55–75 years. According to the intensity and frequency of exercise, the participants were divided into regular-exercise and no-exercise groups. To obtain the average reference value for inhibition ability at the same age, we also recruited 30 healthy elderly people as controls. Results The main defect in the motor inhibition of PD is reactive inhibition, while proactive inhibition has no obvious differences compared with healthy controls. Additionally, compared with the non-exercise group, PD in the exercise group showed significantly better reaction speeds and reactive control ability, fewer motor symptoms and negative emotions. Conclusions Taken together, the motor inhibition defects of patients with PD affect only reactive inhibition. In addition, PD with exercise reported fewer negative emotions than that of the non-exercise group, indicating that exercise can relieve negative emotions and improve behavioral symptoms and quality of life in PD to a certain extent. We demonstrate for the first time that exercise has and can improve reactive inhibition in PD patients and has no effect on proactive inhibition.

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Deep Brain Stimulation of the Internal Globus Pallidus Improves Response Initiation and Proactive Inhibition in Patients With Parkinson’s Disease

Cited by 13 publications

References 52 publications

Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson’s Disease

Microelectrode Arrays Modified with Nanocomposites for Monitoring Dopamine and Spike Firings under Deep Brain Stimulation in Rat Models of Parkinson’s Disease

Proactive inhibition is not modified by deep brain stimulation for Parkinson's disease: An electrical neuroimaging study

Selective effects of exercise on reactive and proactive inhibition in Parkinson’s disease

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