Deep brain stimulation: response to neuronal high frequency stimulation is mediated through GABAA receptor activation in rats

Möser, Andreas; Gieselberg, Annabella; Ro, Bora; Keller, Christine K.; Qadri, Fatimunnisa

doi:10.1016/s0304-3940(03)00133-2

Cited by 39 publications

(28 citation statements)

References 16 publications

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“…Moreover, direct excitation delivered to axons could pace efferent output and/or antidromic stimulation to distant projections, even in the absence of local somatic/perisomatic activation (Li et al 2007;McIntyre et al 2004aMcIntyre et al , 2004b; see also Gradinaru et al 2009). Consistent with these reports in vitro, widespread entrainment of cortical firing activity in the rat (Ozen et al 2010) was reported in vivo upon acute, low-strength, sinusoidal transcranial stimulation. Therefore, it seems plausible to hypothesize that increased locally induced synchronicity might have underlain the behavioral responses at higher frequency stimulation (40 Hz) in our experiments.…”

Section: Discussionsupporting

confidence: 77%

“…3 and 7C,respectively) are similar to the effects of systemic administration to rodents of diazepam and/or vigabatrin, two compounds that increase GABAergic activity in the CNS (Bouwman et al 2004(Bouwman et al , 2005Caudarella et al 1987;Kalueff and Tuohimaa 2005b;Monmaur 1981;Sherif et al 1994). Local GABA increases have been previously associated with DBS both in brain slices (Moser et al 2003) and in vivo (Hiller et al 2007;Liu et al 2012;Windels et al 2000Windels et al , 2003, supporting the speculation that homologous changes might have contributed to our results. Modifications in hippocampal theta frequency are also under the governance of GABAergic interneurons via changes in cholinergic inputs from the medial septum (Buzsáki et al 1986;Dragoi et al 1999;Gillies et al 2002;Givens and Olton 1995).…”

Section: Discussionmentioning

confidence: 73%

“…Nevertheless, safe and effective clinical protocols that would minimally alter cognitive functionality need to be established. Anterior temporal lobectomy and amygdalahippocampectomy are associated with psychiatric disorders (Christodoulou et al 2002;Shaw et al 2004), and verbal and episodic memory decline (Alpherts et al 2006;Gleissner et al 2004;Nunn et al 1998). Such risks are clarified in light of the strong participation of the temporal hippocampus in behaviors with an affective component (Bannerman et al 2004;Gray 1982;Gray and McNaughton 2000) along with episodic memory functions (de Hoz et al 2003;Howland et al 2008;Kjelstrup et al 2008), whereas the amygdala plays a pivotal role in conditioned and unconditioned fear in addition to anxiety and learning (Davis and Whalen 2001).…”

Section: Discussionmentioning

confidence: 99%

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Frequency dependence of behavioral modulation by hippocampal electrical stimulation

Corte

Wei

Chernyy

et al. 2014

Journal of Neurophysiology

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Electrical stimulation offers the potential to develop novel strategies for the treatment of refractory medial temporal lobe epilepsy. In particular, direct electrical stimulation of the hippocampus presents the opportunity to modulate pathological dynamics at the ictal focus, although the neuroanatomical substrate of this region renders it susceptible to altering cognition and affective processing as a side effect. We investigated the effects of three electrical stimulation paradigms on separate groups of freely moving rats (sham, 8-Hz and 40-Hz sinewave stimulation of the ventral/intermediate hippocampus, where 8-and 40-Hz stimulation were chosen to mimic naturally occurring hippocampal oscillations). Animals exhibited attenuated locomotor and exploratory activity upon stimulation at 40 Hz, but not at sham or 8-Hz stimulation. Such behavioral modifications were characterized by a significant reduction in rearing frequency, together with increased freezing behavior. Logistic regression analysis linked the observed changes in animal locomotion to 40-Hz electrical stimulation independently of time-related variables occurring during testing. Spectral analysis, conducted to monitor the electrophysiological profile in the CA1 area of the dorsal hippocampus, showed a significant reduction in peak theta frequency, together with reduced theta power in the 40-Hz vs. the sham stimulation animal group, independent of locomotion speed (theta range: 4 -12 Hz). These findings contribute to the development of novel and safe medical protocols by indicating a strategy to constrain or optimize parameters in direct hippocampal electrical stimulation.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

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Frequency dependence of behavioral modulation by hippocampal electrical stimulation

Corte

Wei

Chernyy

et al. 2014

Journal of Neurophysiology

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“…In rat striatum, Moser et al (2003) and Li et al (2006) also demonstrated the functional consequences of HFSinduced GABA release. When activated, GABA A heteroreceptors on dopaminergic terminals inhibit the release of DA.…”

Section: Proposed Hypothesis: Hfs Selectively Induces Gaba Releasementioning

confidence: 94%

Selective GABA release as a mechanistic basis of high-frequency stimulation used for the treatment of neuropsychiatric diseases

Feuerstein

Kammerer

Lücking

et al. 2011

Naunyn-Schmiedeberg's Arch Pharmacol

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Electrical high-frequency stimulation (HFS) is applied in many brain areas to treat various clinical syndromes. The nearly identical constellation of stimulation parameters raises the question of a unique mechanism of action of this therapeutic option. The identification of a single HFS mechanism may help to optimize the HFS technology by targeting this single mechanism. Experimentally, only axonal membranes are targets of HFS, but not other membranes of neurons or glial cells. Within all HFS target regions, axons of excitatory glutamatergic and inhibitory GABAergic neurons are present and play roles in all clinical syndromes treated successfully with HFS. Therefore, glutamatergic or GABAergic fibres are likely candidates as mediators of a unique HFS mode of action. The selective involvement of another neuronal fibre type (e.g. monoaminergic, cholinergic, etc.) in the HFS mode of action is highly unlikely since the regional and syndromal dissimilarity of the clinical HFS applications precludes the assumption of such a fibre type as primary HFS site of action. Our recent experimental finding that HFS of human neocortical slices induces the action potential-mediated release of GABA, but not of glutamate, simplifies the possibilities to explain the HFS mode of action, as the explanation now may concentrate on GABAergic axons only. Thus, we are analysing, on the basis of the pathophysiological grounds of the various syndromes treated with deep brain stimulation, whether a selective GABA release is a collective explanation of the mode of action of HFS. We suggest that selective GABA release indeed may needfully and sufficiently explain efficacy and side effects of HFS.

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“…To shed some light on this question we investigated the effects of brain micro stimulation in a model region of the rats brain, the caudate putamen [5,6]. We developed a procedure, to implant some type of chronic guidance system onto the rats skull [7].…”

Section: Introductionmentioning

confidence: 99%

Semichronic, Collocated Deep Brain Stimulation and Multisite Recording in Rats

Gritsun

Litza

Hiller

et al. 2006

2006 International Conference on Microtechnologies in Medicine and Biology

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Multisite microelectrode recording represents a suitable procedure to study microphysiology and network interactions in the central nervous system on a short time scale. This enables a deeper understanding of recent neurochemical studies to investigate changes in the neurotransmitter GABA caused by deep brain stimulation at the same position. We describe in the following a semichronic procedure to implant a miniature system bringing both stimulation and monitoring probes in close proximity in the caudate putamen of freely behaving rats. New multisite microelectrodes to replace existing microdialysis probes are built from spun wires, characterized and described. The design of a closed loop recording and stimulating system is discussed.

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Deep brain stimulation: response to neuronal high frequency stimulation is mediated through GABAA receptor activation in rats

Cited by 39 publications

References 16 publications

Frequency dependence of behavioral modulation by hippocampal electrical stimulation

Frequency dependence of behavioral modulation by hippocampal electrical stimulation

Selective GABA release as a mechanistic basis of high-frequency stimulation used for the treatment of neuropsychiatric diseases

Semichronic, Collocated Deep Brain Stimulation and Multisite Recording in Rats

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