Deep Eutectic Solvents Based on Natural Ascorbic Acid Analogues and Choline Chloride

Abstract

Deep eutectic solvents (DES) are one of the most promising green technologies to emerge in recent years given their combination of environmentally friendly credentials and useful functionalities. Considering the continued search for new DESespecially those that exemplify the aforementioned characteristics, we report the preparation of DES based on natural analogues of l-ascorbic acid for the first time. The onset of eutectic melting occurred at temperatures far below the melting point of the individual components and resulted in the generation of glass forming fluids with glass transition temperatures, viscosities and flow behavior that are comparable to similar systems. This work expands the current array of DES that can be produced using naturally occurring components, which given their potential to be bio-derived, interesting physicochemical properties (e. g. propensity to supercool and vitrify) and apparent antibacterial nature, may provide utility within a range of applications.

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from Fucus vesiculosus

“…The compounds rich in hydroxyl groups like AA and TPhC are good hydrogen donors and preferably form bonds with hydrogen bond acceptors like choline chloride [23,56]. Although recently, AA has been introduced for the preparation of NADES [56,57], to the best of our knowledge, we report the extraction of ascorbic acid from seaweeds with NADES for the first time. Carotenoid FX is practically insoluble in water.…”

Natural Cryoprotective and Cytoprotective Agents in Cryopreservation: A Focus on Melatonin

“…Trehalose, glucose, sorbitol and proline constitute the components of DESs, even if other compounds have recently been used to develop new solvents such as naturally occurring l-ascorbic acid (vitamin C) and choline [ 61 ].…”

Assessment of Green Chemistry Metrics for Carbon Dioxide Fixation into Cyclic Carbonates Using Eutectic Mixtures as Catalyst: Comprehensive Evaluation on the Example of a Tannic Acid-Derived System

“…DSC analysis of the ChCl/TA mixtures with HBA/HBD molar ratios ≥23:1 revealed the presence of a single peak at 80 °C, ascribed to the polymorphic phase transition that occurs for crystalline ChCl (from α to β). 30,31 Decreasing the amount of ChCl from 28:1 to 23:1, the peak started to disappear and was no longer observed for the system with a 20:1 HBA/HBD ratio or lower (Figure 3b). These results confirmed the FTIR analysis and led us to conclude that pure ChCl, unbound to TA, was present at higher levels of ChCl (>22:1) in the system, whereas mixtures of HBD and HBA at ratios from 1:12 to 1:22 did not show any phase transition in the temperature range studied.…”