Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products

Socas‐Rodríguez, Bárbara; Torres-Cornejo, Monica Vanessa; Álvarez‐Rivera, Gerardo; Mendiola, J. A.

doi:10.3390/app11114897

Cited by 94 publications

(49 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The literature also describes the potential of using a new generation of green solvents, called natural deep eutectic solvents (NADES). These are mixtures of basic plant metabolites, such as sugars, amino acids, alcohols, organic acids, amines or choline derivatives, which exhibit the properties of ionic liquid and deep eutectic solvents [126]. The potential of NADES in polyphenol extraction is due to their unique properties-viscosity, polarity, and formation of hydrogen bonds with polyphenols [127].…”

Section: Methods Of Polyphenol Isolationmentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

View full text Add to dashboard Cite

Polyphenols are active substances against various types of viral infections. Researchers have characterized methods of how to isolate polyphenols without losing their potential to formulate pharmaceutical products. Researchers have also described mechanisms against common viral infections (i.e., influenza, herpes, hepatitis, rotavirus, coronavirus). Particular compounds have been discussed together with the plants in the biomass in which they occur. Quercetin, gallic acid and epigallocatechin are exemplary compounds that inhibit the growth cycle of viruses. Special attention has been paid to identify plants and polyphenols that can be efficient against coronavirus infections. It has been proven that polyphenols present in the diet and in pharmaceuticals protect us from viral infections and, in case of infection, support the healing process by various mechanisms, i.e., they block the entry into the host cells, inhibit the multiplication of the virus, seal blood vessels and protect against superinfection.

show abstract

Section: Methods Of Polyphenol Isolationmentioning

confidence: 99%

Antiviral Properties of Polyphenols from Plants

Chojnacka

Skrzypczak

Izydorczyk

et al. 2021

Foods

View full text Add to dashboard Cite

show abstract

“…The systems prepared were lactic acid:fructose (DES LA:F ) and lactic acid:urea (DES LA:U ) at a molar ratio of (5:1) and (4:1), respectively. The freeze-dried raw materials were mixed with the prepared solvent systems at a mass ratio of 1:100 (raw materials:DES), and they were stirred for 24 h at 50 • C [25]. Then, the mixtures were centrifuged at 6000 rpm for 15 min at 45 • C to separate the undissolved particles.…”

Section: Extraction Processmentioning

confidence: 99%

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Abdallah

Leonardo

Krstić

et al. 2022

Foods

View full text Add to dashboard Cite

A green technique was developed to extract hyaluronic acid (HA) from tuna vitreous humor (TVH) for its potential application in managing dry eye disease. Deep eutectic solvents (DES) were used to extract HA and were synthesized using natural compounds (lactic acid, fructose, and urea). The DES, the soluble fraction of TVH in DES (SF), and the precipitated extracts (PE) were evaluated for their potential use in dry eye disease treatment. In vitro experiments on human corneal epithelial cell lines and the effect on dry eye-associated microorganisms were performed. The influence of the samples on the HCE viability, their intracellular reactive oxygen species (ROS) scavenging capacity, inflammatory response, and antimicrobial properties were studied. According to the results, all samples displayed an antioxidant effect, which was significantly higher for PE in comparison to SF. Most of the tested samples did not induce an inflammatory response in cells, which confirmed the safety in ophthalmic formulations. In addition, the DES and SF proved to be efficient against the studied bacterial strains, while PE did not show an antimicrobial effect. Hence, both DES and SF at defined concentrations could be used as potential compounds in dry eye disease management.

show abstract

“…DESs represent a new generation of solvents that are emerging as the green solvents of the 21st century, mostly based on low-transition-temperature mixtures of cheap and easily available components. The possible combination of the starting materials to prepare the eutectic solvents is virtually countless; therefore, they are enjoying great success and interest as solvents for extracting bioactive compounds [64][65][66].…”

Section: Ultrasound-assisted Extractionmentioning

confidence: 99%

Valorization of Tomato Waste as a Source of Carotenoids

et al. 2021

View full text Add to dashboard Cite

Fast-accumulating scientific evidence from many studies has revealed that fruits and vegetables are the main source of bioactive compounds; in most cases, wastes and byproducts generated by the food processing industry present similar or a higher content of antioxidant compounds. In recent years, the ever-growing amount of agricultural and food wastes has raised serious concerns from an environmental point of view. Therefore, there is an increasing interest in finding new ways for their processing toward safely upgrading these wastes for recovering high-value-added products with a sustainable approach. Among food waste, the abundance of bioactive compounds in byproducts derived from tomato suggests possibility of utilizing them as a low-cost source of antioxidants as functional ingredients. This contribution gives an overview of latest studies on the extraction methods of carotenoids from tomato waste, along with an evaluation of their antioxidant activity, as well as their industrial applications.

show abstract

Deep Eutectic Solvents for the Extraction of Bioactive Compounds from Natural Sources and Agricultural By-Products

Cited by 94 publications

References 49 publications

Antiviral Properties of Polyphenols from Plants

Antiviral Properties of Polyphenols from Plants

Potential Ophthalmological Application of Extracts Obtained from Tuna Vitreous Humor Using Lactic Acid-Based Deep Eutectic Systems

Valorization of Tomato Waste as a Source of Carotenoids

Contact Info

Product

Resources

About