The production of lindane (gamma isomer of hexachlorocyclohexane, γ-HCH) in the second half of the twentieth century was an inefficient process that generated vast amounts of residues of other HCH isomers, without any pesticide activity. These residues were often dumped in an uncontrolled way or unsecured landfills in points near the production sites, causing hot spots of soil and groundwater contamination on all continents. Given the persistence and hydrophobicity of these pollutants, the problem generated decades ago is still a challenge to be solved. Several technologies, based on physical, chemical, and biological treatments, have been proposed for the remediation of HCH-contaminated soils. This chapter reviews the particularities of this kind of contamination and critically examines the bases and results of the technologies applied, paying special attention to the physicochemical remediation processes.