Deep hypothermia terminates status epilepticus — an experimental study

Kowski, Alexander B.; Kanaan, Hassan; Schmitt, Friedhelm C.; Holtkamp, Martin

doi:10.1016/j.brainres.2012.01.022

Cited by 40 publications

(34 citation statements)

References 38 publications

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“…[62], and the equipment and expertise needed are available in most large surgical centers. Its potential for treating RSE has never been evaluated, although results in experimental SE were encouraging [23, 25]. Our results suggest that cooling to 20°C can be very effective in stopping seizures.…”

Section: Discussionmentioning

confidence: 78%

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Deep hypothermia for the treatment of refractory status epilepticus

Niquet

Baldwin

Gezalian

et al. 2015

Epilepsy & Behavior

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Section: Discussionmentioning

confidence: 78%

“…Liu et al [24] induced SE with kainate in rats kept hypothermic for 4 hours, and in normothermic controls. Seizure reduction was much greater during hypothermia at 23° C. than at 28° C, suggesting that the depth of hypothermia increases its efficacy [25]. …”

Section: Introductionmentioning

confidence: 99%

Deep hypothermia for the treatment of refractory status epilepticus

Niquet

Baldwin

Gezalian

et al. 2015

Epilepsy & Behavior

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“…The emergence of a distant pathological activity can be related to remote effects of the focally induced epilepsy, and not to the direct diffuse effects of the electrical or chemical triggers. Electrical stimulation, in particular of the performant-path, has also been described as a model of induced status epilepticus (237, 238). …”

Section: What We Can Learn From Animal Modelsmentioning

confidence: 99%

Mapping Epileptic Activity: Sources or Networks for the Clinicians?

Pittau¹,

Mégevand

Sheybani

et al. 2014

Front. Neurol.

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Epileptic seizures of focal origin are classically considered to arise from a focal epileptogenic zone and then spread to other brain regions. This is a key concept for semiological electro-clinical correlations, localization of relevant structural lesions, and selection of patients for epilepsy surgery. Recent development in neuro-imaging and electro-physiology and combinations, thereof, have been validated as contributory tools for focus localization. In parallel, these techniques have revealed that widespread networks of brain regions, rather than a single epileptogenic region, are implicated in focal epileptic activity. Sophisticated multimodal imaging and analysis strategies of brain connectivity patterns have been developed to characterize the spatio-temporal relationships within these networks by combining the strength of both techniques to optimize spatial and temporal resolution with whole-brain coverage and directional connectivity. In this paper, we review the potential clinical contribution of these functional mapping techniques as well as invasive electrophysiology in human beings and animal models for characterizing network connectivity.

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“…Rationale: Experimental studies [123–131] showed the anticonvulsant properties of hypothermia that were confirmed in patients with refractory or super-refractory status epilepticus (lasting for more than 24 h) persisting despite maximum treatment. A randomized controlled trial and several reports showed that TTM (32–35 °C) for 24 h was associated with a better control of electrical seizure activity and achievement of burst-suppression pattern [132–134].…”

Section: Resultsmentioning

confidence: 99%

Targeted temperature management in the ICU: guidelines from a French expert panel

Cariou

Payen

Asehnoune

et al. 2017

Ann. Intensive Care

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Over the recent period, the use of induced hypothermia has gained an increasing interest for critically ill patients, in particular in brain-injured patients. The term “targeted temperature management” (TTM) has now emerged as the most appropriate when referring to interventions used to reach and maintain a specific level temperature for each individual. TTM may be used to prevent fever, to maintain normothermia, or to lower core temperature. This treatment is widely used in intensive care units, mostly as a primary neuroprotective method. Indications are, however, associated with variable levels of evidence based on inhomogeneous or even contradictory literature. Our aim was to conduct a systematic analysis of the published data in order to provide guidelines. We present herein recommendations for the use of TTM in adult and paediatric critically ill patients developed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) method. These guidelines were conducted by a group of experts from the French Intensive Care Society (Société de Réanimation de Langue Française [SRLF]) and the French Society of Anesthesia and Intensive Care Medicine (Société Francaise d’Anesthésie Réanimation [SFAR]) with the participation of the French Emergency Medicine Association (Société Française de Médecine d’Urgence [SFMU]), the French Group for Pediatric Intensive Care and Emergencies (Groupe Francophone de Réanimation et Urgences Pédiatriques [GFRUP]), the French National Association of Neuro-Anesthesiology and Critical Care (Association Nationale de Neuro-Anesthésie Réanimation Française [ANARLF]), and the French Neurovascular Society (Société Française Neurovasculaire [SFNV]). Fifteen experts and two coordinators agreed to consider questions concerning TTM and its practical implementation in five clinical situations: cardiac arrest, traumatic brain injury, stroke, other brain injuries, and shock. This resulted in 30 recommendations: 3 recommendations were strong (Grade 1), 13 were weak (Grade 2), and 14 were experts’ opinions. After two rounds of rating and various amendments, a strong agreement from voting participants was obtained for all 30 (100%) recommendations, which are exposed in the present article.

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Deep hypothermia terminates status epilepticus — an experimental study

Cited by 40 publications

References 38 publications

Deep hypothermia for the treatment of refractory status epilepticus

Deep hypothermia for the treatment of refractory status epilepticus

Mapping Epileptic Activity: Sources or Networks for the Clinicians?

Targeted temperature management in the ICU: guidelines from a French expert panel

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