Deep insight into cardiac dysfunction in children and young adults with Wolff–Parkinson–White syndrome using speckle tracking imaging

Akimoto, S; Fukunaga, Hideo; Akiya, Azusa; Hosono, Yu; Iso, Takashi; Shigemitsu, Sachie; Tanaka, Noboru; Tabuchi, Haruna; Hayashi, Hidemori; Sekita, Gaku; Takahashi, Ken; Shimizu, Toshiaki

doi:10.1007/s00380-021-01848-5

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…Recently, Nagai et al 19 used speckle tracking echocardiography to demonstrate an impairment of LV GLS, global circumferential strain, as well as LV EF, in a population of adult patients with WPW (mean age 40 ± 12 years). In a younger population (mean age 14.1 years -range 6.9-21.6 years), Akimoto et al 20 demonstrated, instead, a reduction in mid-basal circumferential strain, but not in LV EF. The same authors 20 also demonstrated a reduction in GLS in WPW patients with right-sided AP, however, patients with left-sided AP presented normal GLS.…”

Section: Discussionmentioning

confidence: 97%

Myocardial work in children with Wolff-Parkinson-White syndrome

Borrelli

Salvo

Ciriello

et al. 2023

Preprint

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Objective Wolff-Parkinson-White Syndrome (WPW) has been associated with reduced local myocardial deformation, and when left ventricular dysfunction is present, catheter ablation of the accessory pathway may be required, even in asymptomatic patients. We aimed to evaluate the diagnostic value of non-invasive myocardial work in predicting subtle abnormalities in myocardial performance in children with WPW. Methods and results Seventy-five paediatric patients (age 8.7 ± 3.5 years) were retrospectively recruited for the study: 25 cases with manifest WPW and 50 age- and sex- matched controls (CTR). Global myocardial work index (MWI) was measured as the area of the left ventricle (LV) pressure-strain loops. From MWI, global Myocardial Constructive Work (MCW), Wasted Work (MWW), and Work Efficiency (MWE) were estimated. In addition, standard echocardiographic parameters of LV function were evaluated. Despite normal LV ejection fraction (EF) and global longitudinal strain (GLS), children with WPW had worse MWI, MCW, MWW and MWE. At multivariate analysis, MWI and MCW were associated with GLS and systolic blood pressure, and QRS was the best independent predictor of low MWE and MWW. In particular, a QRS>110 msec showed good sensitivity and specificity for worse MWE and MWW values. Conclusion In children with WPW, myocardial work indices were found significantly reduced, even in presence of normal LV EF and GLS. This study supports the systematic use of myocardial work during the follow-up of paediatric patients with WPW, and myocardial work analysis may represent a sensitive measure of LV performance and aid in decision-making.

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Section: Discussionmentioning

confidence: 97%

Myocardial work in children with Wolff-Parkinson-White syndrome

Borrelli

Salvo

Ciriello

et al. 2023

Preprint

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“…the APs location with a layer-specific strain analysis. 21 They found that there was a significant difference between the patient and nor-mal groups for the dyssynchrony index only at the base-level, and there was no significant difference between the groups for LVEF; and they showed that layer-specific strains are sensitive indicators for the detection of the early stages of cardiac dysfunction. Similar to their study, we showed that there was a significant difference in the and to identify the factors that affect the efficacy of RFCA.…”

Section: Discussionmentioning

confidence: 99%

“…Akimoto et al. aimed to characterize cardiac dysfunction and clarify sensitive cardiac dysfunction indicators in WPW syndrome patients classified by the APs location with a layer‐specific strain analysis 21 . They found that there was a significant difference between the patient and normal groups for the dyssynchrony index only at the base‐level, and there was no significant difference between the groups for LVEF; and they showed that layer‐specific strains are sensitive indicators for the detection of the early stages of cardiac dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of left atrial and left ventricular functions in patients with Wolff‐Parkinson‐White syndrome before and after radiofrequency catheter ablation using three‐dimensional speckle tracking echocardiography

et al. 2022

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Background Wolff‐Parkinson‐White (WPW) syndrome is one of the most common congenital cardiac abnormalities among ventricular pre‐excitation syndromes. Radiofrequency catheter ablation (RFCA) treatment of accessory pathways (APs) in WPW patients is an established curative therapy restoring normal atrioventricular conduction. We have not encountered any studies evaluating both the LA and LV functions of these patients before and after RFCA with three dimensional‐speckle tracking echocardiography (3D‐speckle tracking echocardiography (STE)). Aim The purpose of the current study was to assess the LA and LV functions in patients with WPW syndrome before and after RFCA using 3D‐STE. Methods A total of 21 patients with WPW syndrome who had been scheduled for RFCA were prospectively recruited for this study. 3D‐STE examinations of the patients were performed 12–24 h before ablation and 1 month after ablation. Results The LV‐global longitudinal strain (LV‐GLS) and LV‐global circumferential strain (LV‐GCS) were significantly depressed in the pre‐RFCA WPW group than in the control group (−14.3 ± 2.1 vs. −21.5 ± 2.2, p < .001; −12.6 ± 1.8 vs. −20.4 ± 1.8, p < .001, respectively). The left atrial strain‐reservoir (LAS‐r) and LAS‐active were significantly decreased in the pre‐RFCA WPW group than in the control group (31.9 ± 2.4 vs. 48.8 ± 2.6, p < .001; 11.7 ± 2 vs. 26.5 ± 2.1, p < .001, respectively). The LV‐GLS, LV‐GCS, LAS‐r, and LAS‐active values improved after RFCA compared to before. Conclusion The results of our study indicated that there are subclinical impairments in LV and LA myocardial dynamics in the apparently healthy WPW patients, and these deteriorations improve after RFCA of AP.

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“…В недавней работе S.Akimoto et al (2021) описаны характеристики продольной и циркулярной деформации у пациентов с лево-и правосторонним расположением ДПП в сравнении со здоровыми субъектами [13]. Продемонстрированы более выраженные функциональные нарушения в группе с правосторонним ДПП.…”

Section: рис 6 фрагменты эндокардиального электрофизиологического исс...unclassified

Examination and treatment of a female patient with symptomatic manifesting WPW phenomenon: case report

Savelev

Каменев

Berman³

et al. 2022

Vestnik aritmologii

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Deep insight into cardiac dysfunction in children and young adults with Wolff–Parkinson–White syndrome using speckle tracking imaging

Cited by 5 publications

References 30 publications

Myocardial work in children with Wolff-Parkinson-White syndrome

Myocardial work in children with Wolff-Parkinson-White syndrome

Evaluation of left atrial and left ventricular functions in patients with Wolff‐Parkinson‐White syndrome before and after radiofrequency catheter ablation using three‐dimensional speckle tracking echocardiography

Examination and treatment of a female patient with symptomatic manifesting WPW phenomenon: case report

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