Deep intracranial extension of squamous cell carcinoma of the scalp

Etlik, Ömer; Bay, Ali; İzmirli, Müzeyyen; Uğraş, Serdar; Yılmaz, Nebi; Turan, Arzu

doi:10.1002/pbc.20427

Cited by 11 publications

(12 citation statements)

References 8 publications

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“…[14][15][16][17][18][19][20][21] Basal and squamous cell carcinomas, angiosarcoma, and dermatofibrosarcoma protuberans can have aggressive and destructive behaviors; invade beyond the periosteum, skull bone, dura, and even brain; and result in profound morbidity and mortality. [22][23][24][25][26][27][28][29][30] In advanced scalp tumors with deep and extensive invasion, an interdisciplinary approach is required to excise tumors completely, reconstruct massive surgical defects successfully, and improve cure rates significantly. 3,31-35…”

Section: Discussionmentioning

confidence: 99%

Malignant cutaneous tumors of the scalp: A study of demographic characteristics and histologic distributions of 398 Taiwanese patients

Chiu¹,

Lin

Kuo

et al. 2007

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 99%

Malignant cutaneous tumors of the scalp: A study of demographic characteristics and histologic distributions of 398 Taiwanese patients

Chiu¹,

Lin

Kuo

et al. 2007

Journal of the American Academy of Dermatology

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“…In one case [19], the central nervous system was reached by direct extension; in the others, there was evidence for perineural invasion. A few cases have arisen from malignant transformation of epidermoid cyst epithelium within the brain [22,23].…”

Section: Discussionmentioning

confidence: 95%

“…Several cases of skin carcinoma causing LM have been reported [17][18][19][20][21]. In one case [19], the central nervous system was reached by direct extension; in the others, there was evidence for perineural invasion.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinomatous meningitis

Karim¹,

Nava

Paal

et al. 2009

Oncol Rev

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A case of leptomeningeal carcinomatosis due to a poorly differentiated malignancy is presented. Immunohistochemistry was used to characterize it as a squamous cell carcinoma. Squamous cell carcinomas rarely invade the meninges. There are few well-founded guidelines for managing patients with this condition. Prognosis is generally poor. A literature review of this entity is provided.A 64-year-old African American man presented to the Otolaryngology Clinic with a 1-month history of a left neck mass. The patient had a history of alcoholic liver cirrhosis with a transjugular intrahepatic portosystemic shunt (TIPS) procedure. He was a tobacco user and had chronic obstructive pulmonary disease. A 1 cm, nontender supraclavicular node was observed. A magnetic resonance imaging (MRI) scan of the neck revealed adenopathy in levels II-V and a mass in the posterior aspect of the left parotid gland, invading both superficial and deep lobes. Fine needle aspiration (FNA) of the mass revealed poorly differentiated carcinoma which was focally positive for pancytokeratin (AE1/AE3) and negative for mucin, CK20 and CK7. Endoscopy revealed no visible lesions in the upper aerodigestive tract or esophagus. An excisional biopsy of the parotid mass revealed metastatic poorly differentiated squamous cell carcinoma that was positive for CK5/6 and P63; and negative for AE1/AE3, CK7, CK20, TTF1, CK8/18, S100, HMB45, MART1, CD45, and CD3. Flow cytometry revealed polyclonal B cells. A computerized tomographic (CT) scan of the chest revealed mediastinal and bilateral axillary adenopathy. A fusion positron emission tomographic (PET) scan/CT scan revealed activity in the neck, mediastinum, and axillae but no other areas of concern. An FNA of a right axillary lymph node revealed poorly differentiated squamous cell carcinoma with an immunohistochemical (IHC) staining pattern identical to that of the neck biopsy. The patient was started on chemotherapy consisting of weekly carboplatin (AUC = 2) and weekly paclitaxel (50 mg/m 2 ). He experienced an immediate hypersensitivity reaction to the first dose of paclitaxel and received gemcitabine 1,000 mg/m 2 every other week in its place thereafter. One week after the first cycle of chemotherapy, the patient was noted to be mildly confused and inappropriate. Some improvement resulted from a decrease in narcotic doses, administered for pain.Prior to his third planned cycle of chemotherapy, he presented to the emergency room for headaches, nausea, vomiting, and photophobia. He was found to be confused and disoriented with tangential speech. He was hemodynamically stable and afebrile. Neurological examination revealed ataxia, but there were no cranial nerve, sensory, or motor deficits. Laboratory values revealed a hematocrit of

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“…In the event of a Marjolin's ulcer, the average manifestation of malignancy was 32.5 years postburn, with metastatic spread via lymphatics. Patients who develop burns at an older age have a decreased interval for development of malignant SCC …”

Section: Discussionmentioning

confidence: 99%

“…Reconstruction of excision defects that extend to the skull may include flaps or skin grafts. SCC of the scalp may be aggressive, invading to the periostieum, skull, dura, and brain . In the event that a biopsy reveals dermal involvement with sparing of the epidermis, the surgeon should consider the possibility of a satellite lesion from a prior surgically treated area, and subsequently perform a wide local excision followed by a split‐thickness skin graft and radiation .…”

Section: Discussionmentioning

confidence: 99%