We evaluate trends in terrestrial water storage over 1950–2100 in CMIP6 climate models against a new global reanalysis from assimilating GRACE and GRACE-FO satellite observations into a hydrological model. To account for different timescales in our analysis, we select regions in which the influence of interannual variability is relatively small and observed trends are assumed to be representative of the development over longer periods. Our results reveal distinct biases in drying and wetting trends in CMIP6 models for several world regions. Specifically, we see high model consensus for drying in the Amazon, which disagrees with the observed wetting. Other regions show a high consensus of models and observations suggesting qualitatively correctly simulated trends, e.g., for the Mediterranean and parts of Central Africa. A high model agreement might therefore falsely indicate a robust trend in water storage if it is not assessed in light of the observed developments. This underlines the potential use of maintaining an adequate observational capacity of water storage for climate change assessments.