Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2

Júlíusson, Pétur Benedikt; Bruserud, Ingvild Særvold; Oehme, Ninnie Helén Bakken; Madsen, André; Forthun, Ingeborg; Balthasar, Melissa; Rosendahl, Karen; Viste, Kristin; Jugessur, Astanand; Schell, Lawrence M.; Bjerknes, Robert; Roelants, Mathieu

doi:10.1080/03014460.2023.2174272

Cited by 7 publications

(1 citation statement)

References 44 publications

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“…However, all studied females were at least 2 years beyond menarche with a mean age of 16.2 years, thus representing a rather homogeneous group of individuals regarding biological maturation. A recent study demonstrated that the age that corresponded to breast developmental stage 4 was 12.5 years in white females [42]. Similarly to our study, previous investigations have also assessed only age at menarche in adolescent females with a similar age range to study the associations between blood biochemical indices and bone mineral values [7,10].…”

Section: Discussionsupporting

confidence: 74%

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

et al. 2023

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Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans. The purpose of the current study was to investigate possible associations of serum follistatin concentration with bone mineral characteristics in lean and physically active adolescent girls. Bone mineral density, body composition, resting energy expenditure and different energy homeostasis hormones in serum including follistatin, leptin and insulin were investigated. Significant relationships (p < 0.05) between serum follistatin (1275.1 ± 263.1 pg/mL) and whole-body (WB) bone mineral content (r = 0.33), WB areal bone mineral density (aBMD) (r = 0.23) and lumbar spine (LS) aBMD (r = 0.29) values were observed. Serum follistatin remained associated with LS aBMD independent of body fat and lean masses (r = 0.21; p < 0.05). However, the follistatin concentration explained only 3% (R2 × 100; p = 0.049) of the total variance in LS aBMD values. In conclusion, serum follistatin concentrations were associated with bone mineral values in lean adolescent girls with increased physical activity. Follistatin was an independent predictor of lumbar spine areal bone mineral density, which predominantly consists of trabecular bone.

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Section: Discussionsupporting

confidence: 74%

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

et al. 2023

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Levels of per- and polyfluoroalkyl substances (PFAS) in Norwegian children stratified by age and sex - Data from the Bergen Growth Study 2

Forthun,

Roelants,

Haug

et al. 2023

International Journal of Hygiene and Environmental Health

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Exposure to Per- and Polyfluoroalkyl Substances and Timing of Puberty in Norwegian Boys: Data from the Bergen Growth Study 2

Forthun,

Roelants,

Knutsen

et al. 2024

Environ. Sci. Technol.

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Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants with endocrine-disruptive properties. Their impact on puberty in boys is unclear. In this cross-sectional study, we investigated the association between PFAS exposure and pubertal timing in 300 Norwegian boys (9–16 years), enrolled in the Bergen Growth Study 2 during 2016. We measured 19 PFAS in serum samples and used objective pubertal markers, including ultrasound-measured testicular volume (USTV), Tanner staging of pubic hair development, and serum levels of testosterone, luteinizing hormone, and follicle-stimulating hormone. In addition to logistic regression of single pollutants and the sum of PFAS, Bayesian and elastic net regression were used to estimate the contribution of the individual PFAS. Higher levels of the sum of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS) were associated with later pubertal onset according to USTV (age-adjusted odds ratio (AOR): 2.20, 95% confidence interval (CI): 1.29, 3.93) and testosterone level (AOR: 2.35, 95% CI: 1.34, 4.36). Bayesian modeling showed that higher levels of PFNA and PFHxS were associated with later pubertal onset by USTV, while higher levels of PFNA and perfluoroundecanoic acid (PFUnDA) were associated with later pubertal onset by testosterone level. Our findings indicate that certain PFAS were associated with delay in male pubertal onset.

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Deep phenotyping of pubertal development in Norwegian children: the Bergen Growth Study 2

Cited by 7 publications

References 44 publications

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Levels of per- and polyfluoroalkyl substances (PFAS) in Norwegian children stratified by age and sex - Data from the Bergen Growth Study 2

Exposure to Per- and Polyfluoroalkyl Substances and Timing of Puberty in Norwegian Boys: Data from the Bergen Growth Study 2

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