Deep Principal Correlated Auto-Encoders With Application to Imaging and Genomics Data Integration

Abstract

In terms of complex diseases like schizophrenia, more and more studies are beginning to treat genetic variants and brain imaging phenotypes as an important factor. In this paper, a competent optimization model is exploited to overcome the weakness of deep canonical correlation analysis (DCCA). The model consists of principal component analysis (PCA) on the multi-modality linear features learning and multilayer belief networks on multi-modality nonlinear features learning. In order to complete a better result of correlation analysis and classification, the output nodes of multi-layer belief network are used for back propagation (BP) network training. Previous works on solving canonical correlation analysis (CCA) had proposed several models based on deep neural network or regularization, typically involving either some form of norm or auto-encoders with a reconstruction objective. Many existing advanced models had been developed to find the maximal correlation in multi-modality data. However, these multi-modality data tend to have the number of feature dimensions which more than that of samples. Differ from these advanced models, our proposed model is applied to analyze the real set of multi-modality data and test several previous models, then comparing them experimentally on fMRI imaging and SNPs genomics. In experiments, the results show that our model, deep principal correlated auto-encoders (DPCAE), learns features with effectively higher correlation and better performance of classification than those previous models. In terms of classification accuracy, the classification accuracy of the datasets exceeds 90%, but that of the CCA-based model are about 65%, and that of the DNN-based model are about 80%, the classification accuracy of the DPCAE is significantly improved obviously. In the experiment of clustering performance evaluation, the DPCAE further verified its superior classification performance with an average normalized mutual information index of 93.75% and an average classification error rate index of 3.8%. In terms of maximal correlation analysis, the model outperforms other advanced models with a maximal correlation of 0.926, showing excellent performance in high-dimensional data analysis.

Applications for Deep Learning in Epilepsy Genetic Research

“…Methodologies for multimodal modelling are rapidly evolving, although the application of these methods in medical research and clinical setting is still in its nascent stages. Li, Wang, et al [80] provide a proof-of-concept for the integration of SNVs and brain image data to delineate schizophrenic patients and healthy controls. The model architecture was designed to detect complex nonlinear relationships between SNV and the image data.…”