Deep vein thrombosis and tuberculosis: a causative link?

Kéchaou, I.; Chérif, E.; Hassine, L. Ben; Khalfallah, N.

doi:10.1136/bcr-2013-200807

Cited by 12 publications

(12 citation statements)

References 4 publications

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“…Tuberculosis and its thrombogenic potential can be a neglected risk factor for deep venous thrombosis [ 2 ]. In the literature, a rare but dangerous linkage between tuberculosis and Deep vein thrombosis has been reported [ 3 - 5 ]. In some cases, the symptoms patients are encountered while DVT treatments or even at the time of admission to the hospital are related to such underlying causes which firstly may not be noticeable.…”

Section: Introductionmentioning

confidence: 99%

Pulmonary tuberculosis: a differential diagnostic priority in unprovoked deep venous thrombosis patients with haemoptysis

2018

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Section: Introductionmentioning

confidence: 99%

Pulmonary tuberculosis: a differential diagnostic priority in unprovoked deep venous thrombosis patients with haemoptysis

2018

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“…There are case reports in the literature associating hypercoagulability with Mycobacterium tuberculosis infection: deep vein thrombosis associated with pulmonary TB, peritoneal TB with secondary portal vein thrombosis, and fatal massive pulmonary embolism despite receiving appropriate RIPE therapy and a therapeutic international normalized ratio. 13 - 15 This is the first reported case, to the authors’ knowledge, of death from a pulmonary embolism in a patient with TB-IRIS from disseminated genitourinary TB.…”

Section: Discussionmentioning

confidence: 81%

“… 16 Tuberculosis treatment, more specifically rifampin, has also been associated with hypercoagulability. 13 …”

Section: Discussionmentioning

confidence: 99%

Fatal Pulmonary Embolism in the Setting of Immune Reconstitution Inflammatory Syndrome Attributed to Ovarian Tuberculosis

Ugalde

Pirela

Presti

et al. 2017

Journal of Investigative Medicine High Impact Case Reports

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In developed countries, tuberculosis remains a health care challenge due to human immunodeficiency virus (HIV) and immigration from endemic regions. The Centers for Disease Control and Prevention reported 9557 new cases in 2015, with extrapulmonary involvement in 20.2% of the cases. We present a 33-year-old woman from Cape Town, South Africa, who developed abdominal pain and fever while working on a cruise ship. She sought medical where she underwent computed tomography of her chest, abdomen, and pelvis with findings suggestive of pulmonary tuberculosis and an 8.9-cm pelvic mass. HIV testing was positive and the patient was started on antiretroviral therapy. Bronchoscopy confirmed the presence of acid-fast bacilli, and she was started on rifampin, isoniazid, pyrazinamide, and ethambutol. She remained persistently febrile, raising suspicion for immune reconstitution inflammatory syndrome. However, despite empiric antibiotics, the patient remained persistently febrile, tachycardic, and on day 10 of admission she went into ventricular fibrillation and expired. Autopsy revealed an occlusive thrombus in the left main pulmonary artery in addition to necrotizing granulomata in multiple organs and bilateral tubo-ovarian abscesses. Postmortem cultures for were positive for Mycobacterium tuberculosis, all consistent with disseminated Mycobacterium tuberculosis. Although previous reports underscore the association between tuberculosis and hypercoagulability, the exact mechanism remains unknown. In this article, we report a case of disseminated tuberculosis complicated by bilateral tubo-ovarian abscesses with fatal pulmonary thrombus formation.

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“…Classically, lower limb VT is more reported as complication of TB 5. However, certain uncommon localisations of VT were described in literature such as internal jugular vein thrombosis complicating disseminated TB,6 septic cavernous sinus thrombosis caused by TB7 and portal vein thrombosis linked to disseminated TB 8.…”

Section: Discussionmentioning

confidence: 99%

Deep vein thrombosis of the left arm revealing an asymptomatic pulmonary tuberculosis

et al. 2019

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Although not frequent, thromboembolic events occurring in patient presenting tuberculosis may be observed. Frequency of such thromboembolic events seems correlated with the severity of tuberculosis. We herein report a case of venous thrombosis revealing an asymptomatic tuberculosis. A man aged 32 years was admitted for deep and superficial vein thrombosis of the left arm. Chest CT angiography ruled out pulmonary embolism and showed a mediastinal and pulmonary heterogeneous necrotic mass at the apical segment of the left lung. Histological study of a CT scan-guided pulmonary biopsy showed signs of caseating granuloma compatible with tuberculosis. Diagnosis of venous thrombosis due to pulmonary tuberculosis with lymph nodes involvement was made. Antituberculosis treatment was initiated and required an adjustment of anticoagulant therapy. Our observation highlights the possibility of causative effect between tuberculosis and venous thrombosis.

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Deep vein thrombosis and tuberculosis: a causative link?

Cited by 12 publications

References 4 publications

Pulmonary tuberculosis: a differential diagnostic priority in unprovoked deep venous thrombosis patients with haemoptysis

Pulmonary tuberculosis: a differential diagnostic priority in unprovoked deep venous thrombosis patients with haemoptysis

Fatal Pulmonary Embolism in the Setting of Immune Reconstitution Inflammatory Syndrome Attributed to Ovarian Tuberculosis

Deep vein thrombosis of the left arm revealing an asymptomatic pulmonary tuberculosis

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