Deep vein thrombosis related to environment

Signorelli, Salvatore Santo; Ferrante, Margherita; Gaudio, Agostino; Fiore, Valerio

doi:10.3892/mmr.2017.6395

Cited by 18 publications

(16 citation statements)

References 47 publications

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“…Exposure to PM has been shown to induce a prothrombotic state, which may play a role in its ability to cause arterial thrombotic (myocardial infarction, ischemic/thrombotic cerebrovascular events) and venous thrombotic events (deep venous thrombosis) ( 81 , 82 ). Exposure to PM induces the production of fibrinogen, and other factors that play a role in hemostasis including Von Willebrand factor, sCD62P, and sCD40L ( 65 , 83 – 85 ).…”

Section: Exposure To Pm and Cardiovascular Diseasementioning

confidence: 99%

Particulate Matter Air Pollution: Effects on the Cardiovascular System

2018

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Air pollution is a complex mixture of gaseous and particulate components, each of which has detrimental effects on human health. While the composition of air pollution varies greatly depending on the source, studies from across the world have consistently shown that air pollution is an important modifiable risk factor for significantly increased morbidity and mortality. Moreover, clinical studies have generally shown a greater impact of particulate matter (PM) air pollution on health than the gaseous components. PM has wide-ranging deleterious effects on human health, particularly on the cardiovascular system. Both acute and chronic exposure to PM air pollution is associated with increased risk of death from cardiovascular diseases including ischemic heart disease, heart failure, and ischemic/thrombotic stroke. Particulate matter has also been shown to be an important endocrine disrupter, contributing to the development of metabolic diseases such as obesity and diabetes mellitus, which themselves are risk factors for cardiovascular disease. While the epidemiological evidence for the deleterious effects of PM air pollution on health is increasingly accepted, newer studies are shedding light on the mechanisms by which PM exerts its toxic effects. A greater understanding of how PM exerts toxic effects on human health is required in order to prevent and minimize the deleterious health effects of this ubiquitous environmental hazard. Air pollution is a growing public health problem and mortality due to air pollution is expected to double by 2050. Here, we review the epidemiological evidence for the cardiovascular effects of PM exposure and discuss current understanding about the biological mechanisms, by which PM exerts toxic effects on cardiovascular system to induce cardiovascular disease.

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Section: Exposure To Pm and Cardiovascular Diseasementioning

confidence: 99%

Particulate Matter Air Pollution: Effects on the Cardiovascular System

2018

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“…long-term inflammation. Signorelli et al (2017) stated that air pollution and inhalation of PM 10 , PM 2.5 and PM 1 play an important role in DVT, PE, and VTE (Signorelli et al, 2017). Emmerechts et al (2012) studied the relation between PM and VTE in Belgium and found that VTE was associated with long-term exposure to air pollution (Emmerechts et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…The factors that can cause DVT include pregnancy, the use of contraceptives, and the use of estrogen hormones to reduce the symptoms of menopause ( Benjamin et al., 2017 ). However, according to some recent studies exposure to polluted air ( Baccarelli et al., 2008 ; Dales et al., 2010 ; Kloog et al., 2015 ; Signorelli et al., 2017 )might be the cause of DVT as well.…”

Section: Introductionmentioning

confidence: 99%

“…Ambient air particles may interfere with pro-coagulants, cause inflammation in the arteries, and have negative effects on platelets, coagulation factors, inflammatory markers, and endothelial markers ( Signorelli et al., 2017 ). Other animal and human studies have shown that exposure to PM can increase hemostasis, release of histamine, and the formation of thrombosis.…”

Section: Introductionmentioning

confidence: 99%

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Air pollution and hospital admissions due to deep vein thrombosis (DVT) in Ahvaz, Iran

Borsi

Khanjani

Nejad

et al. 2020

Heliyon

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There are limited studies on the relation between short-term exposure to air pollutants and the risk of deep venous thrombosis (DVT). The aim of this study was to determine the relation between the concentration of these pollutants and the risk of hospital admissions due to DVT in Ahvaz, which is one of the world's highly polluted cities. Daily data on pollutants including O 3 , NO, NO 2 , SO 2 , CO, PM 10 , and PM 2.5 and DVT hospital admissions were collected from2008until 2018. Quasi-Poisson regression combined with linear distributed lag models; adjusted for trend, seasonality, temperature, relative humidity, weekdays, and holidays were used to assess the relation between the daily average of air pollutants and hospital admission for DVT. The results showed that there was a significant increase in hospital admissions due to DVT in the total, men, women, and elderly populations in relation to NO and NO 2. There was also a significant increase in DVT hospital admissions in the male and 60 years populations related to PM 10 ; and among the female and 60 years old populations, related to PM 2.5. Finally, the results showed that there were significant positive associations between SO2 and CO exposure and the incidence of DVT hospital admissions among men and women, respectively. The results of this study show the possible effect of short-term exposure to air pollution on the risk of DVT. Further studies are required to investigate whether direct interventions through industry and government policy may alter the impact of specific pollutants in order to alter the incidence of DVT and other identified health complications.

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“…Thus, the platelet aggregation rate of thrombosis patients is increased. In the study conducted by Signorelli et al , it was suggested that the platelet aggregation activity of patients with deep vein thrombosis of lower extremity is enhanced ( 15 ). By analyzing the expression of the three substances (PAF, CD62p, and CD63) in the two groups, it was found that the expression levels of the three substances were significantly higher in postpartum deep vein thrombosis patients than in subjects with normal recovery.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism

et al. 2018

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The present study investigated the predictive value of the platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism. From January 2014 to January 2016, 23 patients with postpartum deep vein thrombosis of lower extremity treated in the Department of Obstetrics of Beijing Chaoyang Hospital were as assigned as the observation group. At the same time, 25 cases with normal recovery were assigned as the control group. Blood samples were collected from all the subjects. The platelet aggregation rate was measured using a platelet aggregation apparatus. Plasma platelet activating factor (PAF) levels were measured by ELISA. The positive rate of platelet P-selectin (CD62p) and lysosomal membrane glycoprotein (CD63) was measured by flow cytometry. PI3K expression and AKt phosphorylation levels were measured by western blot analysis. The ROC curve was used to evaluate the value of the platelet aggregation rate in predicting postpartum deep vein thrombosis of lower extremity. The correlation between the platelet aggregation rate and PAF and PI3K/AKt expression was also analyzed. The cesarean section rate, platelet 5-min maximum aggregation rate, PAF level and the positive rate of CD62p and CD63 were significantly higher in the control than those in the observation group (P<0.05). Furthermore, the platelet aggregation rate was positively correlated with the expression of PAF, CD62p and CD63 (r=0.389, 0.451, and 0.452; all P<0.05). The platelet 5-min maximum aggregation rate for predicting postpartum deep vein thrombosis of lower extremity was reflected by the area under the ROC curve (AUC=0.797, P=0.000). The PI3Kp110β/β-actin and p-AKt/AKt ratio was significantly higher in the observation compared with the control group (P<0.05). In addition, the platelet aggregation rate was positively correlated with the expression of PI3K and phosphorylation level of AKt (r=0.441, 0.430; all P<0.05). The results suggested that platelet aggregation activity is elevated in postpartum deep vein thrombosis patients. It has a certain predictive value for the occurrence of postpartum deep vein thrombosis of lower extremity. Thuss, the PI3K/AKt signaling pathway may be one of the mechanisms of platelet aggregation.

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Deep vein thrombosis related to environment

Cited by 18 publications

References 47 publications

Particulate Matter Air Pollution: Effects on the Cardiovascular System

Particulate Matter Air Pollution: Effects on the Cardiovascular System

Air pollution and hospital admissions due to deep vein thrombosis (DVT) in Ahvaz, Iran

Predictive value of platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism

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