Deep venous thrombosis and pulmonary embolism in psychiatric settings

“…Antipsychotic treatment has been linked to higher risk for VTE by most studies [4]. In a most recent report [18], both typical and atypical antipsychotics were associated with higher risk for PE, depending on the specific drug used; highest odds ratio was found for clozapine (OR = 1.47), followed by ziprasidone, risperidone, and olanzapine.…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors can be divided in to congenital, such as hereditary thrombophilia, and acquired, including advanced age, obesity, surgery, malignancies, and estrogen therapy [3]. Recent research has focused on increased risk for VTE in psychiatric settings [4]. …”

Section: Introductionmentioning

confidence: 99%

“…Possible underlying mechanisms are immobilization and dehydration in all three conditions, plus vessel injury in the situation of physical restraint, due to heavy resistance of the patient, or fever and rhabdomyolysis in the case of neuroleptic malignant syndrome [4]. Higher risk for VTE has also been demonstrated for specific classes of psychotropic drugs, most consistently for antipsychotics [9–15].…”

Section: Introductionmentioning

confidence: 99%

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Pulmonary Embolism Related to Amisulpride Treatment: A Case Report

Σκώκου

Gourzis

2013

Case Reports in Psychiatry

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Venous thromboembolism has been associated with antipsychotic drugs, but the underlying mechanisms are largely unknown. Hypotheses that have been made include body weight gain, sedation, enhanced platelet aggregation, increased levels of antiphospholipid antibodies, hyperhomocysteinemia, whereas hyperprolactinemia has recently attracted attention as a potential contributing factor. The highest risk has been demonstrated for clozapine, olanzapine, and low-potency first-generation antipsychotics; however, presently there is no data for amisulpride. In the present paper we describe a case of pulmonary embolism in a female bipolar patient, receiving treatment with amisulpride, aripiprazole, and paroxetine. Although a contribution of aripiprazole and paroxetine cannot completely be ruled out, the most probable factor underlying the thromboembolic event seems to be hyperprolactinemia, which was caused by amisulpride treatment. Increased plasma levels of prolactin should probably be taken into account during the monitoring of antipsychotic treatment as well as in future research concerning venous thromboembolism in psychiatric settings.

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“…2 Atipik antipsikotikler venöz tromboz gelişimini üzerine etkili olan platelet aggregasyonunu etkileyen seratonin reseptör 2A üzerine yüksek afinite gösterirler ve antipsikotik tedavi alan hastalarda görülen artmış antikardiyolipin, antifosfolipit antikor ve lupus antikoagülanı düzeyleri, dislipidemi, hiperleptinemi, insülin rezistansı tromboz gelişiminden sorumlu tutulan diğer faktörler olarak ön plana çıkmaktadır. 1,[5][6][7]10 DVT ve PE çeşitli medikal ve cerrahi durumlarda ortaya çıkan ve koruyucu önlemler gerektiren, hayatı tehdit eden hastalıklardır. Bu koruyucu önlemler arasında fiziksel egzersiz, elastik çorapların giyilmesi, pnömotik kompresyon cihazlarının kullanılması ve subkutan heparin verilmesi yer alır.…”

Section: öZetunclassified

Olanzapine Induced Deep Venous Thrombosis

Genç¹,

Yıldırım²,

Yarbil³

et al. 2011

JAEMCR

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Cause of a lower risk of extrapyramidal side effects atypical antipsychotic drugs are primarily being used more frequently in schizophrenia and mania. Many metabolic side effects particularly such as obesity and dyslipidemia may occur in the use of atypical antipsychotic drugs. Numbers of studies that show a relationship between atypical antipsychotic use and the development of venous thromboembolism have been increasing. We discovered deep venous thrombosis in 33-year-old male patient, who had been using olanzapine due to bipolar disorder, admitted to our emergency service with leg pain and swelling. In this case report we discussed that in a patient without risk factors for developing venous thromboembolism, the use of olanzapine may lead to deep venous thrombosis. Keywords

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Deep venous thrombosis and pulmonary embolism in psychiatric settings

Cited by 16 publications

References 55 publications

Fatal pulmonary thromboembolism after prolonged physical immobilization in hospitalized psychiatric patients

Fatal pulmonary thromboembolism after prolonged physical immobilization in hospitalized psychiatric patients

Pulmonary Embolism Related to Amisulpride Treatment: A Case Report

Olanzapine Induced Deep Venous Thrombosis

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